1-(o-N-methylcarbamoylmethoxyphenoxy)-2,3-epoxypropane | 58027-12-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(o-N-methylcarbamoylmethoxyphenoxy)-2,3-epoxypropane
• 英文别名: 2-(2,3-epoxypropoxy)phenoxy-N-methylacetamide；N-methyl-2-[2-(oxiran-2-ylmethoxy)phenoxy]acetamide
• CAS: 58027-12-6
• 化学式: C₁₂H₁₅NO₄
• 分子量: 237.255
• InChiKey: QSTUROZIGQKUQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  60.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(o-N-methylcarbamoylmethoxyphenoxy)-2,3-epoxypropane 在 palladium on activated charcoal 氢气 作用下， 以 异丙醇 为溶剂， 反应 18.0h， 生成 1-<<2-<2-(2-aminophenyl)acetamido>ethyl>amino>-3-<2-<(N-methylcarbamoyl)methoxy>phenoxy>propan-2-ol
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 23. 1-(Substituted-amido)phenoxy-3-[[(substituted-amido)alkyl]amino]propan-2-ols

  摘要：

  The synthesis of a series of 1-phenoxy-3-[(amidoalkyl)amino]propan-2-ols, in which the phenoxy ring is variously substituted with ortho and para amidic moieties, is described. Several of the compounds have beta-blocking potency comparable to that of propranolol and cardioselectivity similar to that of practolol, when given intravenously to anesthetized cats. In contrast to previous findings with cardioselective beta blockers, both ortho and para substitution give variable degrees of cardioselectivity. Potency, however, is favored by ortho substitution.

  DOI：

  10.1021/jm00357a008
• 作为产物：
  描述：

  生成 1-(o-N-methylcarbamoylmethoxyphenoxy)-2,3-epoxypropane
  参考文献：
  名称：

  Drugs Fut. 1983, 8, 305

  摘要：

  DOI：

文献信息

• Substituted 3-phenoxy-1-alkoxycarbonylalkylamino-propanol-2-s having
  申请人：E. I. du Pont de Nemours & Co.

  公开号：US05051446A1

  公开（公告）日：1991-09-24

  The present invention relates to new compounds of the formula I ##STR1## as well as their preparation, pharmaceutical preparations containing same, and method of treating acute myocardial infarction. The compounds which possess beta-adrenoceptor blocking activity are very shortacting and are preferably intended for treatment of acute myocardial infarction by administration by means of injection.

  本发明涉及公式I的新化合物，以及它们的制备、含有这些化合物的药物制剂，以及治疗急性心肌梗死的方法。具有β-肾上腺素受体阻滞活性的这些化合物作用时间很短，最好用注射的方式进行急性心肌梗死的治疗。
• Method for producing .beta.-adrenergic blockage with alkanolamine
  申请人：Imperial Chemical Industries Limited

  公开号：US03959486A1

  公开（公告）日：1976-05-25

  New 1-amino-3-carbamoylalkoxyphenoxypropan-2-ol derivatives, for example 1-t-butylamino-3-(o-N-methylcarbamoylmethoxyphenoxy)propane-2-ol, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess .beta.-adrenergic blocking activity and are useful in the treatment of heart diseases and other conditions in man.

  新的1-氨基-3-氨甲酰氧基苯氧丙醇衍生物，例如1-t-丁基氨基-3-(o-N-甲基氨甲酰氧基苯氧)丙烷-2-醇，其制造方法以及含有它们的药物组合物。这些化合物具有β-肾上腺素能阻滞活性，并可用于治疗心脏疾病和其他人类疾病。
• Alkanolamine derivatives
  申请人：Imperial Chemical Industries Limited

  公开号：US04059622A1

  公开（公告）日：1977-11-22

  New 1-amino-3-(o-carbamoylalkoxyphenoxy)propan-2-ol derivatives, for example 1-t-butylamino-3-(o-N-methylcarbamoylmethoxyphenoxy)propan-2-ol, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess .beta.-adrenergic blocking activity and are useful in the treatment of heart diseases and other conditions in man.

  新的1-氨基-3-(o-氨基甲酰氧烷氧基)丙烷-2-醇衍生物，例如1-t-丁基氨基-3-(o-N-甲基氨基甲酰氧基苯氧基)丙烷-2-醇，其制造方法和含有它们的制药组合物。这些化合物具有β-肾上腺素能阻断活性，可用于治疗人体心脏疾病和其他病症。
• New substituted 3-phenoxy-1-alkoxycarbonyl-alkylamino-propanol-2-s having beta receptor blocking properties
  申请人：Aktiebolaget Hässle

  公开号：EP0041492A1

  公开（公告）日：1981-12-09

  The present invention relates to new compounds of the formula as well as their preparation, pharmaceutical preparations containing same, and method of treating acute myocardial infarction. The compounds which possess beta-adrenoceptor blocking activity are very shortacting and are preferably intended for treatment of acute myocardial infarction by administration by means of injection.

  本发明涉及新的式化合物 以及它们的制备方法、含有它们的药物制剂和治疗急性心肌梗塞的方法。 具有β-肾上腺素受体阻断活性的化合物接触时间很短，最好通过注射给药的方式用于治疗急性心肌梗塞。
• CH614925
  申请人：——

  公开号：——

  公开（公告）日：——