2-(5-Methyl-2-oxazolyl)phenol | 128064-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(5-Methyl-2-oxazolyl)phenol
• 英文别名: 2-(5-Methyl-oxazol-2-yl)-phenol；2-(5-methyl-1,3-oxazol-2-yl)phenol
• CAS: 128064-22-2
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: OTNCOLYEJCEERG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻乙酰水杨酰氯 在 sodium hydroxide 、 sodium hydride 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 3.17h， 生成 2-(5-Methyl-2-oxazolyl)phenol
  参考文献：
  名称：

  Freedman, Jules; Huber, Edward W., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 4, p. 343 - 346

  摘要：

  DOI：

文献信息

• METHODS FOR TREATING HUNTINGTON'S DISEASE
  申请人：PTC Therapeutics, Inc.

  公开号：EP3386511A1

  公开（公告）日：2018-10-17
• METHODS FOR MODIFYING RNA SPLICING
  申请人：PTC Therapeutics, Inc.

  公开号：EP3638318A1

  公开（公告）日：2020-04-22
• [EN] METHODS FOR TREATNG HUNTINGTON'S DISEASE<br/>[FR] MÉTHODES DE TRAITEMENT DE LA MALADIE DE HUNTINGTON
  申请人：PTC THERAPEUTICS INC

  公开号：WO2017100726A1

  公开（公告）日：2017-06-15

  The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
• [EN] METHODS FOR MODIFYING RNA SPLICING<br/>[FR] PROCÉDÉS DE MODIFICATION DE L'ÉPISSAGE DE L'ARN
  申请人：PTC THERAPEUTICS INC

  公开号：WO2018232039A1

  公开（公告）日：2018-12-20

  Described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a small molecule splicing modifier compound of Formula (I) provided herein or a form thereof, wherein W, X, A and B are as defined herein. In one aspect, methods for modifying RNA splicing to modulate the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene that contains an intronic REMS is modified utilizing a splicing modifier compound of Formula (I), are described herein. In another aspect, methods for modifying RNA splicing to modulate the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene is modified to comprise an intronic REMS utilizing a splicing modifier compound of Formula (I), are described herein.