1-(((3,3-ethylenedioxy-1-phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene | 874375-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(((3,3-ethylenedioxy-1-phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene
• 英文别名: 1-(((3,3-ethylenedioxy-1-phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)-benzene；7-[[3,5-bis(trifluoromethyl)phenyl]methoxymethyl]-7-phenyl-1,4-dioxaspiro[4.5]decane
• CAS: 874375-82-3
• 化学式: C₂₄H₂₄F₆O₃
• 分子量: 474.443
• InChiKey: YELVDSLOWSVUJW-UHFFFAOYSA-N

物化性质

• 沸点：
  447.5±40.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1-(((3,3-ethylenedioxy-1-phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene 在 盐酸 、 sodium azide 、 硼烷四氢呋喃络合物 、 三氟乙酸 作用下， 以 水 、 丙酮 、 苯 为溶剂， 反应 5.0h， 生成 (S)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane
  参考文献：
  名称：

  Discovery of disubstituted piperidines and homopiperidines as potent dual NK 1 receptor antagonists–serotonin reuptake transporter inhibitors for the treatment of depression

  摘要：

  This report describes the synthesis, structure-activity relationships and activity of piperidine, homopiperidine, and azocane derivatives combining NK1 receptor (NK1R) antagonism and serotonin reuptake transporter (SERT) inhibition. Our studies culminated in the discovery of piperidine 2 and homopiperidine 8 as potent dual NK1R antagonists-SERT inhibitors. Compound 2 demonstrated significant activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.02.010
• 作为产物：
  描述：

  5,6-二氢-[1,1’-联苯]-3(4H)-酮 在 sodium tetrahydroborate 、 4-甲基苯磺酸吡啶 、 三甲胺盐酸盐 、 sodium hydride 、 二异丁基氢化铝 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 、 甲苯 、 mineral oil 、 苯 为溶剂， 反应 9.0h， 生成 1-(((3,3-ethylenedioxy-1-phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene
  参考文献：
  名称：

  Discovery of disubstituted piperidines and homopiperidines as potent dual NK 1 receptor antagonists–serotonin reuptake transporter inhibitors for the treatment of depression

  摘要：

  This report describes the synthesis, structure-activity relationships and activity of piperidine, homopiperidine, and azocane derivatives combining NK1 receptor (NK1R) antagonism and serotonin reuptake transporter (SERT) inhibition. Our studies culminated in the discovery of piperidine 2 and homopiperidine 8 as potent dual NK1R antagonists-SERT inhibitors. Compound 2 demonstrated significant activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.02.010

文献信息

• Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists
  申请人：Wu Yong-Jin

  公开号：US20060019944A1

  公开（公告）日：2006-01-26

  The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds are useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

  本公开涉及化合物及其在人类治疗中的应用。公开的一个具体实施例涉及公式（I）的化合物；或其异构体、药学上可接受的盐或溶剂，或包含所述化合物的药学上可接受的制剂，用于治疗或预防由速激肽介导的疾病和/或选择性抑制血清素再摄取转运蛋白的条件。这些化合物作为双重NK-1拮抗剂和选择性血清素再摄取抑制剂。
• Homopiperidine derivatives as NK-1 antagonists
  申请人：Wu Yong-Jin

  公开号：US20060019943A1

  公开（公告）日：2006-01-26

  The present disclosure relates to chemical compounds and their use in human therapy. In a specific embodiment, compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.

  本公开涉及化合物及其在人类治疗中的应用。在一个具体实施例中，公式（I）的化合物或其异构体，药学上可接受的盐或溶剂，或包含该化合物的药学上可接受的制剂，用于治疗或预防由缓激肽介导的疾病和/或选择性抑制血清素再摄取转运蛋白的条件。这些化合物作为双重NK-1拮抗剂和选择性血清素再摄取抑制剂。
• US7098203B2
  申请人：——

  公开号：US7098203B2

  公开（公告）日：2006-08-29
• US7276631B2
  申请人：——

  公开号：US7276631B2

  公开（公告）日：2007-10-02
• [EN] CYCLOPENTYLAMINE AND CYCLOHEXYLAMINE DERIVATIVES AS NK-1/SSRI ANTAGONISTS<br/>[FR] CYCLOPENTYLAMINE ET DERIVES DE CYCLOHEXYLAMINE UTILISES COMME ANTAGONISTES DE NK-1/SSRI
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2006014664A2

  公开（公告）日：2006-02-09

  The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds are useful for the useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.