4-(2-amino-phenoxy)-butyric acid methyl ester | 856046-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-amino-phenoxy)-butyric acid methyl ester
• 英文别名: 4-(2-Amino-phenoxy)-buttersaeure-methylester；Methyl 4-(2-aminophenoxy)butanoate
• CAS: 856046-24-7
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: VFNBZOGPCVCOCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(乙酰基氧基)-4-氯-7-甲氧基-3-喹啉甲腈 、 4-(2-amino-phenoxy)-butyric acid methyl ester 在 三乙胺 作用下， 以 异丙醇 为溶剂， 反应 6.0h， 生成 Methyl 4-[2-[(6-acetyloxy-3-cyano-7-methoxyquinolin-4-yl)amino]phenoxy]butanoate
  参考文献：
  名称：

  [EN] 3-CYANO-QUINOLINE DERIVATIVES WITH ANTIPROLIFERATIVE ACTIVITY
  [FR] DERIVES DE 3-CYANO-QUINOLINE A ACTIVITE ANTIPROLIFERATIVE

  摘要：

  本发明涉及式(I)的化合物，其N-氧化物形式，药用可接受的加合盐以及其立体化异构体形式。式(I)的化合物抑制酪氨酸激酶酶。

  公开号：

  WO2005058318A1
• 作为产物：
  描述：

  N-(2-(3-cyanopropoxy)phenyl)acetamide 在 盐酸 作用下， 生成 4-(2-amino-phenoxy)-butyric acid methyl ester
  参考文献：
  名称：

  Jacobs; Heidelberger, Journal of the American Chemical Society, 1917, vol. 39, p. 2221

  摘要：

  DOI：

文献信息

• 3-Cyano-Quinoline Derivatives With Antiproliferative Activity
  申请人：Freyne Eddy Jean Edgard

  公开号：US20080139601A1

  公开（公告）日：2008-06-12

  The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents NH; Y represents —C 3-9 alkyl-, —C 1-5 alkyl-NR 12 —C 1-5 alkyl-, —C 1-6 alkyl-NH—CO— or —CO—NH—C 1-6 alkyl-; X 1 represents —O—; X 2 represents a direct bond, —NR 11 —C 1-2 alkyl-, —NR 11 —CH 2 —, —C 1-2 alkyl-, —O—C 1-2 alkyl, —O— or —O—CH 2 —; R 1 represents hydrogen or halo; R 2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C 1-4 alkyloxycarbonyl-, Het 16 -carbonyl- or Ar 5 ; R 3 represents hydrogen, hydroxy, C 1-4 alkyloxy-, Ar 4 —C 1-4 alkyloxy or R 3 represents C 1-4 alkyloxy substituted with one or where possible two or more substituents selected from C 1-4 alkyloxy- or Het 2 -; R 10 represents hydrogen; R 11 represents hydrogen, C 1-4 alkyl- or C 1-4 alkyl-oxy-carbonyl-; R 12 represents Het 14 -C 1-4 alkyl, in particular morpholinyl-C 1-4 alkyl; Het 2 represents a heterocycle selected from morpholinyl or piperidinyl optionally substituted with C 1-4 alkyl-, preferably methyl; Het 14 represents morpholinyl; Het 16 represents a heterocycle selected from morpholinyl or pyrrolidinyl; Ar 4 represents phenyl; Ar 5 represents phenyl optionally substituted with cyano.
• 3-CYANO-QUINOLINE DERIVATIVES WITH ANTIPROLIFERATIVE ACTIVITY
  申请人：FREYNE Eddy Jean Edgard

  公开号：US20100069424A1

  公开（公告）日：2010-03-18

  The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents NH; Y represents —C 3-9 alkyl-, —C 1-5 alkyl-NR 12 —C 1-5 alkyl-, —C 1-6 alkyl-NH—CO— or —CO—NH—C 1-6 alkyl-; X 1 represents —O—; X 2 represents a direct bond, —NR 11 —C 1-2 alkyl-, —NR 11 —CH 2 —, —C 1-2 alkyl-, —O—C 1-2 alkyl, —O— or —O—CH 2 —; R 1 represents hydrogen or halo; R 2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C 1-4 alkyloxycarbonyl-, Het 16 -carbonyl- or Ar 5 ; R 3 represents hydrogen, hydroxy, C 1-4 alkyloxy-, Ar 4 —C 1-4 alkyloxy or R 3 represents C 1-4 alkyloxy substituted with one or where possible two or more substituents selected from C 1-4 alkyloxy- or Het 2 -; R 10 represents hydrogen; R 11 represents hydrogen, C 1-4 alkyl- or C 1-4 alkyl-oxy-carbonyl-; R 12 represents Het 14 -C 1-4 alkyl, in particular morpholinyl-C 1-4 alkyl; Het 2 represents a heterocycle selected from morpholinyl or piperidinyl optionally substituted with C 1-4 alkyl-, preferably methyl; Het 14 represents morpholinyl; Het 16 represents a heterocycle selected from morpholinyl or pyrrolidinyl; Ar 4 represents phenyl; Ar 5 represents phenyl optionally substituted with cyano.
• US20140256948A1
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  公开号：US20140256948A1

  公开（公告）日：2014-09-11
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  申请人：——

  公开号：US7655642B2

  公开（公告）日：2010-02-02
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  申请人：——

  公开号：US8778920B2

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