hexa-2t,4t-dienedioic acid monoamide | 4941-87-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: hexa-2t,4t-dienedioic acid monoamide
• 英文别名: Hexa-2t,4t-diendisaeure-monoamid；trans-trans-5-Carbamoyl-penta-2,4-diensaeure；Muconamic acid；(2E,4E)-6-amino-6-oxohexa-2,4-dienoic acid
• CAS: 4941-87-1
• 化学式: C₆H₇NO₃
• 分子量: 141.126
• InChiKey: IHLJLVTWZZJGPD-ZPUQHVIOSA-N

物化性质

• 沸点：
  417.8±37.0 °C(Predicted)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 hexa-2t,4t-dienedioic acid monoamide 生成 hexa-2t,4t-dienedioic acid amide-methyl ester
  参考文献：
  名称：

  Elvidge et al., Journal of the Chemical Society, 1953, p. 1793,1796

  摘要：

  DOI：
• 作为产物：
  描述：

  (2E,4E)-5-methoxycarbonyl-2,4.pentadienoic acid 在 氨 、 水 作用下， 生成 hexa-2t,4t-dienedioic acid monoamide
  参考文献：
  名称：

  Elvidge et al., Journal of the Chemical Society, 1953, p. 1793,1796

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING epsilon-CAPROLACTAM
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20200062704A1

  公开（公告）日：2020-02-27

  The present invention is a method of producing ε-caprolactam through adipamide as an intermediate, and characteristically includes a lactamization step of reacting adipamide, formed from a material compound, with hydrogen and ammonia in the presence of a catalyst containing: a metal oxide mainly containing an oxide(s) of one or more metallic elements selected from the group consisting of metallic elements of group 5 and groups 7 to 14 in the 4th to 6th periods of the periodic table; and a metal and/or a metal compound having a hydrogenation ability. The method can increase the selectivity of ε-caprolactam.

  本发明是一种通过己内酰胺作为中间体生产ε-己内酰胺的方法，其特征在于包括一种内酰胺化步骤，即在催化剂的存在下，将由材料化合物形成的己内酰胺与氢气和氨气反应，所述催化剂包含：主要含有来自周期表第4至第6周期的5族和7至14族金属元素氧化物的金属氧化物；以及具有氢化能力的金属和/或金属化合物。该方法可以提高ε-己内酰胺的选择性。
• Adhesion of textile cords to rubber by dip coating using an N-methylol group containing polymer
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0027538A2

  公开（公告）日：1981-04-29

  A tire cord dipping composition and a method of adhering textile materials to rubber, are disclosed, wherein an N-methylol group containing polymer is employed.

  本发明公开了一种轮胎帘子线浸渍组合物和一种将纺织材料粘附到橡胶上的方法，其中使用了一种含 N-甲醇基团的聚合物。
• METHOD FOR PRODUCING -CAPROLACTAM
  申请人：Toray Industries, Inc.

  公开号：EP3553048A1

  公开（公告）日：2019-10-16

  The present invention is a method of producing ε-caprolactam through adipamide as an intermediate, and characteristically includes a lactamization step of reacting adipamide, formed from a material compound, with hydrogen and ammonia in the presence of a catalyst containing: a metal oxide mainly containing an oxide(s) of one or more metallic elements selected from the group consisting of metallic elements of group 5 and groups 7 to 14 in the 4th to 6th periods of the periodic table; and a metal and/or a metal compound having a hydrogenation ability. The method can increase the selectivity of ε-caprolactam.

  本发明是一种以己二胺为中间体生产ε-己内酰胺的方法，其特征在于包括一个内酰胺化步骤，即在催化剂存在下，使由材料化合物形成的己二胺与氢气和氨气反应，催化剂含有：主要含有一种或多种金属元素氧化物的金属氧化物，这些金属元素选自元素周期表第4至第6周期的第5族和第7至第14族金属元素组成的组；以及一种金属和/或一种具有氢化能力的金属化合物。该方法可提高ε-己内酰胺的选择性。
• Methods and materials for reducing the risk of infections
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US10201555B2

  公开（公告）日：2019-02-12

  This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.

  本文涉及降低肩部手术或医疗程序后感染风险的方法和材料。例如，本文涉及使用含有克林霉素或红霉素的局部组合物来降低或预防与肩部手术或医疗程序相关的感染风险的方法和材料。
• Treatment of skin disorders by topical administration of VEGF inhibitors
  申请人：AMD THERAPEUTICS LLC

  公开号：US10709702B2

  公开（公告）日：2020-07-14

  Topical administration of VEGF inhibitors such as, without limitation, rifamycin compounds are useful for treating skin disorders such as treating and/or reducing scars such as hypertrophic scars, and useful for treating acne and underlying acne symptoms such as skin redness.

  局部使用血管内皮生长因子抑制剂（如但不限于利福霉素化合物）可用于治疗皮肤疾病，如治疗和/或减少疤痕（如增生性疤痕），还可用于治疗痤疮和潜在的痤疮症状（如皮肤发红）。