N-[2-(9-isopropyl-9H-purin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline | 1535484-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[2-(9-isopropyl-9H-purin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline
• 英文别名: N-[2-(9-propan-2-ylpurin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline
• CAS: 1535484-01-5
• 化学式: C₂₂H₁₇F₆N₅
• 分子量: 465.401
• InChiKey: PIROGVVZHVGETH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N-[2-(9-isopropyl-9H-purin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline 、 benzaldehyde N-boc imine 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以56%的产率得到tert-butyl-{3-[3,5-bis(trifluoromethyl)phenylamino]-2-(9-isopropyl-9H-purin-6-yl)phenyl}(phenyl)methylcarbamate
  参考文献：
  名称：

  Hydrogen-Bond-Assisted Controlled C–H Functionalization via Adaptive Recognition of a Purine Directing Group

  摘要：

  We have developed the Rh-catalyzed selective C-H functionalization of 6-arylpurines, in which the purine moiety directs the C-H bond activation of the aryl pendant. While the first C-H amination proceeds via the N1-chelation assistance, the subsequent second C-H bond activation takes advantage of an intramolecular hydrogen-bonding interaction between the initially formed amino group and one nitrogen atom, either N1 or N7, of the purinyl part. Isolation of a rhodacycle intermediate and the substrate variation studies suggest that N1 is the main active site for the C-H functionalization of both the first and second amination in 6-arylpurines, while N7 plays an essential role in controlling the degree of functionalization serving as an intramolecular hydrogen-bonding site in the second amination process. This pseudo-Curtin-Hammett situation was supported by density functional calculations, which suggest that the intramolecular hydrogen-bonding capability helps second amination by reducing the steric repulsion between the first installed ArNH and the directing group.

  DOI：

  10.1021/ja4118472
• 作为产物：
  描述：

  3,5-bis(trifluoromethyl)phenyl azide 、 9-isopropyl-6-phenyl-9H-purine 在 silver hexafluoroantimonate 、 C₂₄H₂₉ClN₄Rh 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 12.0h， 以78%的产率得到N-[2-(9-isopropyl-9H-purin-6-yl)phenyl]-3,5-bis(trifluoromethyl)aniline
  参考文献：
  名称：

  Hydrogen-Bond-Assisted Controlled C–H Functionalization via Adaptive Recognition of a Purine Directing Group

  摘要：

  We have developed the Rh-catalyzed selective C-H functionalization of 6-arylpurines, in which the purine moiety directs the C-H bond activation of the aryl pendant. While the first C-H amination proceeds via the N1-chelation assistance, the subsequent second C-H bond activation takes advantage of an intramolecular hydrogen-bonding interaction between the initially formed amino group and one nitrogen atom, either N1 or N7, of the purinyl part. Isolation of a rhodacycle intermediate and the substrate variation studies suggest that N1 is the main active site for the C-H functionalization of both the first and second amination in 6-arylpurines, while N7 plays an essential role in controlling the degree of functionalization serving as an intramolecular hydrogen-bonding site in the second amination process. This pseudo-Curtin-Hammett situation was supported by density functional calculations, which suggest that the intramolecular hydrogen-bonding capability helps second amination by reducing the steric repulsion between the first installed ArNH and the directing group.

  DOI：

  10.1021/ja4118472

文献信息

• Hydrogen-Bond-Assisted Controlled C–H Functionalization via Adaptive Recognition of a Purine Directing Group
  作者：Hyun Jin Kim、Manjaly J. Ajitha、Yongjae Lee、Jaeyune Ryu、Jin Kim、Yunho Lee、Yousung Jung、Sukbok Chang

  DOI：10.1021/ja4118472

  日期：2014.1.22

  We have developed the Rh-catalyzed selective C-H functionalization of 6-arylpurines, in which the purine moiety directs the C-H bond activation of the aryl pendant. While the first C-H amination proceeds via the N1-chelation assistance, the subsequent second C-H bond activation takes advantage of an intramolecular hydrogen-bonding interaction between the initially formed amino group and one nitrogen atom, either N1 or N7, of the purinyl part. Isolation of a rhodacycle intermediate and the substrate variation studies suggest that N1 is the main active site for the C-H functionalization of both the first and second amination in 6-arylpurines, while N7 plays an essential role in controlling the degree of functionalization serving as an intramolecular hydrogen-bonding site in the second amination process. This pseudo-Curtin-Hammett situation was supported by density functional calculations, which suggest that the intramolecular hydrogen-bonding capability helps second amination by reducing the steric repulsion between the first installed ArNH and the directing group.