3-氨甲基-5-氟吡啶 | 23586-96-1

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-氨甲基-5-氟吡啶
• 中文别名: 3-氨基甲基-5-氟吡啶
• 英文名称: (5-fluoropyridin-3-yl)methanamine
• 英文别名: (5-fluoro-3-pyridyl)-methanamine；(5-Fluoropyridin-3-yl)methylamine
• CAS: 23586-96-1
• 化学式: C₆H₇FN₂
• 分子量: 126.133
• InChiKey: RYICOVXDBBDCNT-UHFFFAOYSA-N

物化性质

• 沸点：
  93-94 °C(Press: 14 Torr)
• 密度：
  1.180±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: (5-Fluoropyridin-3-yl)methylamine
Synonyms: (5-Fluoropyridin-3-yl)methanamine

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: (5-Fluoropyridin-3-yl)methylamine
CAS number: 23586-96-1

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H7FN2
Molecular weight: 126.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-氨甲基-5-氟吡啶 在 potassium carbonate 、 一水合肼 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 5-bromo-N1-((5-fluoropyridin-3-yl)methyl)benzene-1,2-diamine
  参考文献：
  名称：

  US2014/275153

  摘要：

  公开号：
• 作为产物：
  描述：

  3-氰基-2,6-二氯-5-氟吡啶 在 palladium 10% on activated carbon 盐酸 、 氢气 、 potassium acetate 作用下， 以 乙醇 、 水 为溶剂， 20.0 ℃ 、432.29 kPa 条件下， 反应 6.0h， 生成 3-氨甲基-5-氟吡啶
  参考文献：
  名称：

  [EN] CB1 MODULATOR COMPOUNDS
  [FR] COMPOSES MODULATEURS DE CB1

  摘要：

  结构式（I）的新化合物已被披露。作为大麻素-1（CB1）受体的调节剂，这些化合物在治疗、预防和抑制由CB1受体介导的疾病方面是有用的。因此，本发明的化合物在治疗、预防和抑制精神病、记忆缺陷、认知障碍、偏头痛、神经病、神经炎性疾病（例如多发性硬化症、吉兰-巴雷综合征和病毒性脑炎的炎症后遗症）、脑血管意外、头部创伤、焦虑症、压力、癫痫、帕金森病和精神分裂症方面是有用的。这些化合物还可用于治疗物质滥用障碍，特别是对阿片类药物、酒精和尼古丁的治疗。这些化合物还可用于治疗与过度食物摄入及相关并发症相关的肥胖症或进食障碍。

  公开号：

  WO2005066126A1

文献信息

• HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS
  申请人：CHANGZHOU YINSHENG PHARMACEUTICAL CO., LTD.

  公开号：US20170253614A1

  公开（公告）日：2017-09-07

  A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.

  一系列丙型肝炎病毒（HCV）抑制剂及其组合物，以及在制备用于治疗慢性HCV感染的药物时的应用。特别是一系列用作NS5A抑制剂的化合物，以及在药物制剂中的组合物和用途。
• [EN] COMPOUNDS AND THERAPEUTIC USES THEREOF<br/>[FR] COMPOSÉS ET SES UTILISATIONS THÉRAPEUTIQUES
  申请人：MYREXIS INC

  公开号：WO2012177782A1

  公开（公告）日：2012-12-27

  The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and complications associated with these diseases and disorders.

  这项发明涉及化合物、药物组合物和方法，用于治疗癌症、全身性或慢性炎症、类风湿性关节炎、糖尿病、肥胖症、T细胞介导的自身免疫疾病、缺血以及与这些疾病和疾病相关并发症。
• Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors
  作者：Guoqiang Dong、Wei Chen、Xia Wang、Xinglin Yang、Tianying Xu、Pei Wang、Wannian Zhang、Yu Rao、Chaoyu Miao、Chunquan Sheng

  DOI：10.1021/acs.jmedchem.7b00467

  日期：2017.10.12

  report the first small molecules that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC), two important targets of cancer metabolism and epigenetics, respectively. Through iterative structure-based drug design, chemical synthesis, and biological assays, a highly potent dual NAMPT and HDAC inhibitor was successfully identified. Compound 35 possessed excellent

  癌症的代谢和表观遗传学是抗癌药物发现中最受关注的研究领域之一。在这里，我们报告了第一个同时抑制烟酰胺磷酸核糖基转移酶（NAMPT）和组蛋白脱乙酰基酶（HDAC）的小分子，这两个小分子分别是癌症代谢和表观遗传学的两个重要目标。通过基于迭代结构的药物设计，化学合成和生物学分析，成功鉴定出了高效的NAMPT和HDAC双重抑制剂。化合物35对NAMPT（IC 50 = 31 nM）和HDAC1（IC 50 = 55 nM）均具有出色且平衡的活性。它可以有效诱导细胞凋亡和自噬，并最终导致细胞死亡。重要的是，化合物35在HCT116异种移植模型中显示出优异的体内抗肿瘤功效。这项概念验证研究证明了发现针对癌症代谢和表观遗传学的抑制剂的可行性，并为发现多靶点抗肿瘤药物提供了有效的策略。
• [EN] HETEROCYCLIC INHIBITORS OF STEAROYL-COA DESATURASE<br/>[FR] INHIBITEURS HÉTÉROCYCLIQUES DE LA STÉAROYL-COA DÉSATURASE
  申请人：NOVARTIS AG

  公开号：WO2009103739A1

  公开（公告）日：2009-08-27

  The present invention provides heterocyclic derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

  本发明提供了式（I）的杂环衍生物，可调节硬脂酰辅酶A去饱和酶的活性。还涵盖了利用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法，以及包含这些衍生物的药物组合物。
• [EN] SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME<br/>[FR] COMPOSÉS 1,1'-BIPHÉNYLE SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ARBUTUS BIOPHARMA INC

  公开号：WO2021158481A1

  公开（公告）日：2021-08-12

  The present invention includes substituted 1,1'-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.

  本发明包括取代的1,1'-联苯化合物，其类似物，以及包含它们的组合物。在一个方面，本发明中考虑的化合物可用于治疗、改善或预防患者体内的乙型肝炎病毒（HBV）和/或丙型肝炎病毒（HDV）感染。在另一个方面，本发明中考虑的化合物可用于治疗、改善和/或预防患者体内的癌症。