Bis-(4-guanylphenoxy)-methan | 118499-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Bis-(4-guanylphenoxy)-methan
• 英文别名: 4-[(4-Carbamimidoylphenoxy)methoxy]benzenecarboximidamide
• CAS: 118499-87-9
• 化学式: C₁₅H₁₆N₄O₂
• 分子量: 284.318
• InChiKey: UVWKMRBKLGSZLA-UHFFFAOYSA-N

物化性质

• 沸点：
  497.8±55.0 °C(predicted)
• 密度：
  1.30±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,4’-(methylenebis(oxy))dibenzonitrile 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 以44.8%的产率得到Bis-(4-guanylphenoxy)-methan
  参考文献：
  名称：

  Discovery of decamidine as a new and potent PRMT1 inhibitor

  摘要：

  这份报告介绍了十甲胺作为蛋白质精氨酸甲基转移酶1（PRMT1）的有效抑制剂的合成和评价。

  DOI：

  10.1039/c6md00573j

文献信息

• MATRIPTASE INHIBITORS AND USES THEREOF AGAINST ORTHOMYXOVIRIDAE INFECTIONS
  申请人：SOCPRA SCIENCES SANTE ET HUMAINES S.E.C.

  公开号：US20160097052A1

  公开（公告）日：2016-04-07

  The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flu infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and preventing orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

  本发明提供了抑制matriptase的抑制剂和用于治疗和预防流感等正黏涂病毒感染的组合物。本发明还提供了用于抑制matriptase的新化合物、组合物、使用方法、用途和工具包。这些化合物可用于治疗和预防正黏涂病毒感染，如流感感染，并用于抑制肿瘤生长、进展和/或转移。
• [EN] COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES ET LA POTENTIALISATION D'ANTIBIOTIQUES
  申请人：UNIV GEORGIA STATE RES FOUND

  公开号：WO2021127452A1

  公开（公告）日：2021-06-24

  Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.

  本文提供了用于治疗由革兰氏阳性细菌、革兰氏阴性细菌和/或分枝杆菌引起的细菌感染的化合物和方法。本文还提供了用于增强抗生素在治疗细菌感染中的效果的化合物和方法。还提供了包括本文所述化合物的药物组合物。
• Amidine derivatives for treating amyloidosis
  申请人：Chalifour J. Robert

  公开号：US20070021483A1

  公开（公告）日：2007-01-25

  The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

  本发明涉及在治疗与淀粉样相关疾病中使用氨基脲类化合物。特别地，本发明涉及一种治疗或预防受试者淀粉样相关疾病的方法，包括向受试者施用治疗剂量的氨基脲类化合物。根据本发明使用的化合物包括以下化学式的化合物，当施用时，可减少或抑制淀粉样纤维形成、神经退行性或细胞毒性：
• BACTERIAL EFFLUX PUMP INHIBITORS FOR THE TREATMENT OF OPHTHALMIC AND OTIC INFECTIONS
  申请人：Bostian Keith

  公开号：US20080132457A1

  公开（公告）日：2008-06-05

  Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear).

  流出泵抑制剂与抗微生物药物一起联合使用，用于治疗眼科或耳科感染。这些药物可以直接共同应用于感染部位（例如眼睛或耳朵）。
• USES OF PENTAMIDINE AND RELATED COMPOUNDS
  申请人：Berglund John Andrew

  公开号：US20100323993A1

  公开（公告）日：2010-12-23

  Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.

  本文提供了一种治疗肌无力萎缩症和其他毒性RNA疾病的方法。在某些例子中，该方法包括给受体注射一种化合物，该化合物能够结合核糖核酸分子中的核苷酸重复扩展，从而治疗该疾病。在其他例子中，该方法包括给受体注射一种化合物，该化合物能够破坏肌肉盲样蛋白与RNA核苷酸重复扩展的结合。用于该方法的化合物包括戊二酸二甲胺或庚二酸二甲胺或其衍生物。本文描述了代表性化合物。