(5Z)-2-ethylsulfanyl-3-methyl-5-(4-phenylmethyloxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | 1416577-10-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (5Z)-2-ethylsulfanyl-3-methyl-5-(4-phenylmethyloxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
• 英文别名: (5Z)-2-ethylsulfanyl-3-methyl-5-[(4-phenylmethoxyphenyl)methylidene]imidazol-4-one
• CAS: 1416577-10-0
• 化学式: C₂₀H₂₀N₂O₂S
• 分子量: 352.457
• InChiKey: AHMYYHRPYOSBIL-AQTBWJFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-双(3-氨基丙基)哌嗪 、 (5Z)-2-ethylsulfanyl-3-methyl-5-(4-phenylmethyloxybenzylidene)-3,5-dihydro-4H-imidazol-4-one 反应 0.5h， 以24%的产率得到(5Z)-3-methyl-2-[3-[4-[3-[[(4Z)-1-methyl-5-oxo-4-[(4-phenylmethoxyphenyl)methylidene]imidazolidin-2-ylidene]amino]propyl]piperazin-1-yl]propylimino]-5-[(4-phenylmethoxyphenyl)methylidene]imidazolidin-4-one
  参考文献：
  名称：

  Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

  摘要：

  The synthesis in 4 steps of new N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N'-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3 alpha/beta, DYRK1A, CLK1 and CLK3). Crown Copyright (C) 2012 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.08.044
• 作为产物：
  描述：

  对羟基苯甲醛 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 121.5h， 生成 (5Z)-2-ethylsulfanyl-3-methyl-5-(4-phenylmethyloxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
  参考文献：
  名称：

  Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

  摘要：

  The synthesis in 4 steps of new N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N'-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3 alpha/beta, DYRK1A, CLK1 and CLK3). Crown Copyright (C) 2012 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.08.044

文献信息

• Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases
  作者：Wacothon Karime Coulibaly、Ludovic Paquin、Anoubilé Bénie、Yves-Alain Bekro、Emilie Durieu、Laurent Meijer、Jean Pierre Bazureau

  DOI：10.1016/j.ejmech.2012.08.044

  日期：2012.12

  The synthesis in 4 steps of new N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N'-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3 alpha/beta, DYRK1A, CLK1 and CLK3). Crown Copyright (C) 2012 Published by Elsevier Masson SAS. All rights reserved.