The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-l-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.
本发明提供有机硝基
硫醚化合物、含有该类化合物的组合物、分离的有机硝基
硫醚化合物以及使用该类化合物和组合物治疗患者癌症的方法。本文所述的示例有机硝基
硫醚化合物包括2-(3,3-二硝基
氮杂环丙烷-1-基)-2-
氧代乙基
硫醚及其变体。本发明的另一个方面提供了一种制药组合物,包括一种药学上可接受的载体和本文所述的有机硝基
硫醚化合物,例如公式I或II的化合物。本发明的另一个方面提供了一种治疗患者癌症的方法。该方法包括向需要治疗癌症的患者投予本文所述的有机硝基
硫醚化合物的治疗有效量,例如公式I或II的化合物,以治疗癌症。