[(1S)-1-(furan-2-yl)-2-hydroxyethyl] benzoate | 381164-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1S)-1-(furan-2-yl)-2-hydroxyethyl] benzoate
• CAS: 381164-73-4
• 化学式: C₁₃H₁₂O₄
• 分子量: 232.236
• InChiKey: OMMYYMQTSYGHOY-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(1S)-1-(furan-2-yl)-2-hydroxyethyl] benzoate 在 甲醇 、 三乙胺 作用下， 生成 (1S)-(2-furyl)ethane-1,2-diol
  参考文献：
  名称：

  Total synthesis and anti-leishmanial activity of R-(−)-argentilactone

  摘要：

  Starting from the commercially available D-glucal (2), the naturally Occurring alpha,beta -unsaturated delta -lactone argentilactone (1a) has been synthesized. The important step is the configuration inversion at C-6 by the Mitsunobu reaction following the sugar-non-sugar-sugar strategy. The synthetic argentilactone has been tested against Leishmania mexicana for bioactivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01559-3
• 作为产物：
  描述：

  D-葡萄烯糖 在 吡啶 、 硫酸 、 苯甲酰氯 、 mercury(II) sulfate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 5.0h， 生成 [(1S)-1-(furan-2-yl)-2-hydroxyethyl] benzoate
  参考文献：
  名称：

  Total synthesis and anti-leishmanial activity of R-(−)-argentilactone

  摘要：

  Starting from the commercially available D-glucal (2), the naturally Occurring alpha,beta -unsaturated delta -lactone argentilactone (1a) has been synthesized. The important step is the configuration inversion at C-6 by the Mitsunobu reaction following the sugar-non-sugar-sugar strategy. The synthetic argentilactone has been tested against Leishmania mexicana for bioactivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01559-3

文献信息

• Total synthesis and anti-leishmanial activity of R-(−)-argentilactone
  作者：Muhammad Saeed、Thomas Ilg、Miriam Schick、Muhammad Abbas、Wolfgang Voelter

  DOI：10.1016/s0040-4039(01)01559-3

  日期：2001.10

  Starting from the commercially available D-glucal (2), the naturally Occurring alpha,beta -unsaturated delta -lactone argentilactone (1a) has been synthesized. The important step is the configuration inversion at C-6 by the Mitsunobu reaction following the sugar-non-sugar-sugar strategy. The synthetic argentilactone has been tested against Leishmania mexicana for bioactivity. (C) 2001 Elsevier Science Ltd. All rights reserved.