bromopalladium(1+);methyl 5-[3,5-bis[(dimethylamino)methyl]benzene-4-id-1-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate | 552888-07-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bromopalladium(1+);methyl 5-[3,5-bis[(dimethylamino)methyl]benzene-4-id-1-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate
• CAS: 552888-07-0
• 化学式: C₂₃H₃₈BrN₃O₄Pd
• 分子量: 606.896
• InChiKey: KHYRENARMMRRNB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  lithium hydroxide monohydrate 、 bromopalladium(1+);methyl 5-[3,5-bis[(dimethylamino)methyl]benzene-4-id-1-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以42%的产率得到5-[3,5-bis[(dimethylamino)methyl]benzene-4-id-1-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid;bromopalladium(1+)
  参考文献：
  名称：

  The Suzuki cross-coupling reaction: a powerful tool for the attachment of organometallic ‘NCN’-pincer units to biological scaffolds

  摘要：

  Platinum(II) and palladium(II)-NCN {NCN is the terdentate coordinating monoanionic 'pincer' ligand [C6H3(CH2NMe2)(22,6)](-)} complexes have been covalently bonded via their para-position to both the a-carbon of an a-amino acid and to the gamma-position of an alkyl phosphonate by means of Suzuki cross-coupling reactions. The resulting platinurn(II) complexes can be used as biomarkers, while the palladium(II) analogs are active Lewis-acid catalysts. Both the pincer-metal substituted a-amino acid and phosphonate can be used to introduce these organometallic units in biomolecules such as proteins or enzymes. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(02)02099-5
• 作为产物：
  描述：

  tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 Methyl 5-[4-bromo-3,5-bis[(dimethylamino)methyl]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate 以 苯 为溶剂， 以66%的产率得到bromopalladium(1+);methyl 5-[3,5-bis[(dimethylamino)methyl]benzene-4-id-1-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate
  参考文献：
  名称：

  The Suzuki cross-coupling reaction: a powerful tool for the attachment of organometallic ‘NCN’-pincer units to biological scaffolds

  摘要：

  Platinum(II) and palladium(II)-NCN {NCN is the terdentate coordinating monoanionic 'pincer' ligand [C6H3(CH2NMe2)(22,6)](-)} complexes have been covalently bonded via their para-position to both the a-carbon of an a-amino acid and to the gamma-position of an alkyl phosphonate by means of Suzuki cross-coupling reactions. The resulting platinurn(II) complexes can be used as biomarkers, while the palladium(II) analogs are active Lewis-acid catalysts. Both the pincer-metal substituted a-amino acid and phosphonate can be used to introduce these organometallic units in biomolecules such as proteins or enzymes. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(02)02099-5