5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl}-2,4-oxazolidinedione | 132646-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl}-2,4-oxazolidinedione
• 英文别名: 5-[[4-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,3-oxazolidine-2,4-dione
• CAS: 132646-30-1
• 化学式: C₂₂H₂₀N₂O₅
• 分子量: 392.411
• InChiKey: NNOISTKKYFQVRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  90.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole 在 methyl magnesium carbonate 、 三氟乙酸 作用下， 反应 4.0h， 生成 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl}-2,4-oxazolidinedione
  参考文献：
  名称：

  Benzyloxazolidine-2,4-diones as potent hypoglycemic agents

  摘要：

  A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

  DOI：

  10.1021/jm00109a003

文献信息

• PROPIONIC ACID DERIVATIVES AND APPLICATIONS THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP0930299A1

  公开（公告）日：1999-07-21

  A novel propionic acid derivative of the formula (I): and a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing the derivative. The propionic acid derivative and a pharmaceutically acceptable salt thereof have superior hypoglycemic action and are expected to show hypolipidemic action and to be useful as therapeutic agents for diabetes and complications of diabetes, as well as related diseases such as hyperlipemia.

  一种新颖的式 (I) 丙酸衍生物： 及其药学上可接受的盐，以及含有该衍生物的药物组合物。该丙酸衍生物及其药学上可接受的盐具有卓越的降血糖作用，并有望显示出降血脂作用，可用作糖尿病和糖尿病并发症以及高脂血症等相关疾病的治疗剂。
• Oxazolidinedione hypoglycemic agents
  申请人：PFIZER INC.

  公开号：EP0428312B1

  公开（公告）日：1994-12-28
• DOW, ROBERT L.;BECHLE, BRUCE M.;CHOU, THOMAS T.;CLARK, DAVID A.;HULIN, BE+, J. MED. CHEM., 34,(1991) N, C. 1538-1544
  作者：DOW, ROBERT L.、BECHLE, BRUCE M.、CHOU, THOMAS T.、CLARK, DAVID A.、HULIN, BE+

  DOI：——

  日期：——
• ISOXAZOLIDINEDIONE DERIVATIVE AND USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP0684242B1

  公开（公告）日：1999-05-06
• US5498621A
  申请人：——

  公开号：US5498621A

  公开（公告）日：1996-03-12