四甲基辛二酰胺 | 27397-05-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 四甲基辛二酰胺
• 中文别名: 5-[(E)-2-氰基乙烯基]-2'-脱氧尿苷
• 英文名称: N,N,N',N'-tetramethyloctanediamide
• 英文别名: N,N,N',N'-tetramethyloctanamide；N.N.N'.N'-Tetramethyl-suberinsaeurediamid；Suberinsaeure-bis-dimethylamid；Tetramethyl-suberamid；Tetramethylsuberamid；Tetramethylsuberamide
• CAS: 27397-05-3
• 化学式: C₁₂H₂₄N₂O₂
• mdl: MFCD01683463
• 分子量: 228.335
• InChiKey: OLJJVAJUHCXYHL-UHFFFAOYSA-N

物化性质

• 沸点：
  370.15°C (rough estimate)
• 密度：
  1.0136 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  四甲基辛二酰胺 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 N,N,N',N'-Tetramethyl-1,8-diaminooctane
  参考文献：
  名称：

  Polivka,Z. et al., Collection of Czechoslovak Chemical Communications, 1970, vol. 35, p. 1131 - 1146

  摘要：

  DOI：
• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 生成 四甲基辛二酰胺
  参考文献：
  名称：

  Alkylation of alkylidenebis(dialkylamines) with alkyl dihalides

  摘要：

  DOI：

  10.1021/jo00921a013

文献信息

• Catalytic Hydrogenation for Producing Amines from Carboxylic Acid Amides, Carboxylic Acid Diamides, Di-, Tri-, or Polypeptides, or Peptide Amides
  申请人：Evonik Degussa GmbH

  公开号：US20160272571A1

  公开（公告）日：2016-09-22

  The present invention relates to a process for the preparation of amines, comprising the following steps: a. reaction of a (i) carboxylic acid amide of the general formula (I), or (ii) carboxylic acid diamide of the general formula (II), or (iii) di-, tri- or polypeptide, or (iv) peptide amide with carboxy-terminal amide function with an alkylating agent, b. addition of a hydrogenation catalyst to the reaction mixture in a molar ratio of from 1:10 to 1:100 000, based on carboxylic acid amide, carboxylic acid diamide, di-, tri- or polypeptide or peptide amide, c. reaction of the reaction mixture with hydrogen, where a hydrogen pressure of from 0.1 bar to 200 bar is established and where a temperature in a range of from 0° C. to 250° C. is established.

  本发明涉及一种氨基的制备方法，包括以下步骤：a. 将通式（I）的羧酸酰胺，或通式（II）的羧酸二酰胺，或二肽、三肽或多肽，或带有羧基末端酰胺功能的肽酰胺与烷基化剂发生反应，b. 在摩尔比为1:10至1:100,000的范围内向反应混合物中加入氢化催化剂，基于羧酸酰胺、羧酸二酰胺、二肽、三肽或多肽或肽酰胺，c. 将反应混合物与氢气反应，在此建立氢气压力为0.1巴至200巴，并在0°C至250°C的温度范围内进行反应。
• Synthesis of phenols by the intramolecular condensation of β, β' ,δ ,δ'-tetraoxoalkanedioates a novel BF3 -promoted claisen condensation of
  作者：Masahiko Yamaguchi、Keisuke Shibato、Hisataka Nakashima、Toru Minami

  DOI：10.1016/s0040-4020(01)86179-2

  日期：1988.1

  The aromatization process of β, β', δ , δ'-tetraoxoalkanedioates, which were synthesized by the BF3-promoted Claisen condensation, was examined.

  考察了由BF 3促进的克莱森缩合反应合成的β，β'，δ，δ'-四氧代链烷二酸酯的芳构化过程。
• Method for the prevention of malaria infection of humans by hepatocyte growth factor antagonists
  申请人：——

  公开号：US20040185050A1

  公开（公告）日：2004-09-23

  A method for the prevention of infection of humans by plasmodium parasites is provided. The method consists of the application of compounds that interfere with the infection of hepatocytes by Plasmodium viax.

  本研究提供了一种预防人类感染疟原虫的方法。 该方法包括应用干扰 viax 疟原虫感染肝细胞的化合物。
• Conformation-directing effects of a single intramolecular amide-amide hydrogen bond: variable-temperature NMR and IR studies on a homologous diamide series
  作者：Samuel H. Gellman、Gregory P. Dado、Gui Bai Liang、Bruce R. Adams

  DOI：10.1021/ja00004a016

  日期：1991.2

  We have studied intramolecular hydrogen bonding in a homologous series of diamides (compounds 1-6) in methylene chloride, 9:1 carbon tetrachloride/benzene, and acetonitrile. By correlating variable-temperature H-1 NMR and IR measurements, we have shown that the temperature dependence of the amide proton NMR chemical shift (DELTA-delta/DELTA-T) can provide qualitative (and in some cases quantitative) information on the thermodynamic relationship between the intramolecularly hydrogen bonded and non-hydrogen-bonded states of flexible molecules. Among the hydrogen-bonded ring sizes represented in the diamide series, the intramolecular interaction is particularly enthalpically favorable in the nine-membered hydrogen-bonded ring (compound 4). Variable-temperature IR and NMR data indicate that the internally hydrogen bonded state of diamide 4 is 1.4-1.6 kcal/mol more favorable enthalpically than the non-hydrogen-bonded state, in methylene chloride solution; the non-hydrogen-bonded state is 6.8-8.3 eu more favorable entropically in this solvent. In contrast, there appear to be much smaller enthalpy differences between the internally hydrogen bonded and non-hydrogen-bonded states of diamides 2 and 3. Our findings are important methodologically because the temperature dependences of amide proton chemical shifts are commonly used to elucidate peptide conformation in solution. Our results show that previous "rules" for the interpretation of such data are incomplete. In non-hydrogen-bonding solvents, small amide proton DELTA-delta/DELTA-T values have been taken to mean that the proton is either entirely free of hydrogen bonding or completely locked in an intramolecular hydrogen bond over the temperature range studied. We demonstrate that an amide proton can be equilibrating between intramolecularly hydrogen bonded and non-hydrogen-bonded states and still manifest a small chemical shift temperature dependence (implying that the hydrogen-bonded and non-hydrogen-bonded states are of similar enthalpy).
• YAMAGUCHI, MASAHIKO;SHIBATO, KEISUKE;NAKASHIMA, HISATAKA;MINAMI, TORU, TETRAHEDRON, 44,(1988) N 15, C. 4767-4775
  作者：YAMAGUCHI, MASAHIKO、SHIBATO, KEISUKE、NAKASHIMA, HISATAKA、MINAMI, TORU

  DOI：——

  日期：——