(3-(4-methoxyphenyl)propyl)zinc(II) bromide | 1012042-00-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3-(4-methoxyphenyl)propyl)zinc(II) bromide
• CAS: 1012042-00-0
• 化学式: C₁₀H₁₃BrOZn
• 分子量: 294.507
• InChiKey: GZRWMNDLQNGPIS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  13.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (5R,7aR)-5-(iodomethyl)-1,7a-dihydropyrrolo[1,2-c]oxazol-3(5H)-one 、 (3-(4-methoxyphenyl)propyl)zinc(II) bromide 在 bis(1,5-cyclooctadiene)nickel (0) 、 (S,S)-2,6-双(4-异丙基-2-恶唑啉-2-基)吡啶 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 20.0h， 以65%的产率得到(5S,7aR)-5-{4-(4-methoxyphenyl)butyl}-1,7a-dihydropyrrolo[1,2-c]oxazol-3(5H)-one
  参考文献：
  名称：

  Synthesis and biological evaluation of α-1-C-4′-arylbutyl-l-arabinoiminofuranoses, a new class of α-glucosidase inhibitors

  摘要：

  A series of alpha-1-C-4'-arylbutyl-L-arabinoiminofuranoses 3 with functional groups attached to the phenyl ring, which are potential alpha-glycosidase inhibitors, was designed and synthesized by using a Negishi cross-coupling reaction as the key reaction. Arylbutyl derivatives 3a-e showed potent inhibitory activities against intestinal maltase. Among them, difluorophenylbutyl derivative 3e showed good inhibition activities against intestinal isomaltase and sucrase as compared to those of 1 and commercial drugs. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.06.001
• 作为产物：
  描述：

  1-(3-溴丙基)-4-甲氧基苯 在 碘 、 锌 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 3.0h， 生成 (3-(4-methoxyphenyl)propyl)zinc(II) bromide
  参考文献：
  名称：

  Synthesis and biological evaluation of α-1-C-4′-arylbutyl-l-arabinoiminofuranoses, a new class of α-glucosidase inhibitors

  摘要：

  A series of alpha-1-C-4'-arylbutyl-L-arabinoiminofuranoses 3 with functional groups attached to the phenyl ring, which are potential alpha-glycosidase inhibitors, was designed and synthesized by using a Negishi cross-coupling reaction as the key reaction. Arylbutyl derivatives 3a-e showed potent inhibitory activities against intestinal maltase. Among them, difluorophenylbutyl derivative 3e showed good inhibition activities against intestinal isomaltase and sucrase as compared to those of 1 and commercial drugs. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.06.001