2-nitro-4-methoxy-5-(3,4-dichlorophenoxy)aniline hydrochloride | 198130-52-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitro-4-methoxy-5-(3,4-dichlorophenoxy)aniline hydrochloride
• 英文别名: [5-(3,4-Dichlorophenoxy)-4-methoxy-2-nitrophenyl]azanium;chloride；[5-(3,4-dichlorophenoxy)-4-methoxy-2-nitrophenyl]azanium;chloride
• CAS: 198130-52-8
• 化学式: C₁₃H₁₀Cl₂N₂O₄*ClH
• 分子量: 365.6
• InChiKey: UAYQMUMKYZXFLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.71
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  90.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-nitro-4-methoxy-5-(3,4-dichlorophenoxy)aniline hydrochloride 在 sodium tetrahydroborate 、 磷酸 、 palladium on activated charcoal 、 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 5-[3,4-Dichlorophenoxy]-6-methoxy-8-[4-phthalimido-1-methyl-butylamino]lepidine
  参考文献：
  名称：

  Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs

  摘要：

  8-Aminoquinolines (8-AQs) are important class of anti-infective therapeutics. 5-Phenoxy 8-aminoquinoline analogs have shown improved metabolic stability compared to primaquine. In view or predictive role of monoamine oxidases (MAO) in metabolism of 8-aminoquinolines the 5-phenoxy analogs were evaluated in vitro for the inhibition of recombinant human MAO-A and MAO-B. The analogs were several folds more potent inhibitors of MAO-A and MAO-B compared to primaquine, the parent drug, with selectivity for MAO-B. 5-(4-Trifluoromethylphenoxy)-4-methylprimaquine (6) Inhibited MAO-B with IC50 value of 150 nM (626-fold more potent than primaquine). These results will have important implications in optimizing metabolic stability of 8-AQs to improve therapeutic value and also indicate scope for development of 8-AQs as selective MAO inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.108
• 作为产物：
  描述：

  3,4-二氯苯酚 在 盐酸 、 水 、 potassium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-nitro-4-methoxy-5-(3,4-dichlorophenoxy)aniline hydrochloride
  参考文献：
  名称：

  Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs

  摘要：

  8-Aminoquinolines (8-AQs) are important class of anti-infective therapeutics. 5-Phenoxy 8-aminoquinoline analogs have shown improved metabolic stability compared to primaquine. In view or predictive role of monoamine oxidases (MAO) in metabolism of 8-aminoquinolines the 5-phenoxy analogs were evaluated in vitro for the inhibition of recombinant human MAO-A and MAO-B. The analogs were several folds more potent inhibitors of MAO-A and MAO-B compared to primaquine, the parent drug, with selectivity for MAO-B. 5-(4-Trifluoromethylphenoxy)-4-methylprimaquine (6) Inhibited MAO-B with IC50 value of 150 nM (626-fold more potent than primaquine). These results will have important implications in optimizing metabolic stability of 8-AQs to improve therapeutic value and also indicate scope for development of 8-AQs as selective MAO inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.108

文献信息

• 8-AMINOQUINOLINES
  申请人：——

  公开号：US20010007031A1

  公开（公告）日：2001-07-05

  It has been found that one of the enantiomers of 8-aminoquinoline antiparasitic compounds is surprisingly more active than the other enantiomer against parasitic infections including opportunistic parasitic infections. These enantiomers as well as pharmaceutical compositions containing pure enantiomers are disclosed. Also disclosed is a novel class of 8-aminoquinolines which contain a tri-substituted phenoxy substitution.

  已经发现，8-氨基喹啉抗寄生虫化合物的对映体之一比另一对映体在对抗寄生虫感染（包括机会性寄生虫感染）方面表现出更高的活性。这些对映体以及含有纯对映体的药物组合物已被披露。还披露了一类新型的含有三取代苯氧基取代的8-氨基喹啉。
• [EN] 8-AMINOQUINOLINES<br/>[FR] 8-AMINOQUINOLINES
  申请人：THE UNIVERSITY OF MISSISSIPPI

  公开号：WO1997036590A1

  公开（公告）日：1997-10-09

  (EN) It has been found that one of the enantiomers of 8-aminoquinoline antiparasitic compounds is surprisingly more active than the other enantiomer against parasitic infections including opportunistic parasitic infections. These enantiomers as well as pharmaceutical compositions containing pure enantiomers are disclosed. Also disclosed is a novel class of 8-aminoquinolines which contain a tri-substituted phenoxy substitution.(FR) On a découvert que l'un des énantiomères des composés antiparasitaires à base de 8-aminoquinolines est considérablement plus actif que les autres de ces énantiomères contre les infections parasitaires, y compris les infections parasitaires opportunistes. La présente invention concerne donc de tels énantiomères ainsi que des compositions pharmaceutiques contenant des énantiomères purs. L'invention concerne également une nouvelle classe de 8-aminoquinolines à substitution phénoxy trisubstitué.

  已经发现，8-氨基喹啉类抗寄生虫化合物的其中一种对寄生虫感染，包括机会性寄生虫感染，比另一种对映体表现出更强的活性。本发明揭示了这些对映体以及含有纯对映体的药物组合物。同时，本发明还揭示了一类新型的8-氨基喹啉类化合物，其中含有三取代苯氧基置换。
• 8-aminoquinolines
  申请人：The University of Mississippi

  公开号：US06376511B2

  公开（公告）日：2002-04-23

  It has been found that one of the enantiomers of 8-aminoquinoline antiparasitic compounds is surprisingly more active than the other enantiomer against parasitic infections including opportunistic parasitic infections. These enantiomers as well as pharmaceutical compositions containing pure enantiomers are disclosed. Also disclosed is a novel class of 8-aminoquinolines which contain a tri-substituted phenoxy substitution.

  研究发现，8-氨基喹啉类抗寄生虫化合物的对映体之一比另一对映体更有效，可用于治疗包括机会性寄生虫感染在内的寄生虫感染。本发明揭示了这些对映体以及含有纯对映体的药物组合物。还揭示了一类新的8-氨基喹啉类化合物，其中包含三取代苯氧基取代。
• EP0907363A4
  申请人：——

  公开号：EP0907363A4

  公开（公告）日：2005-04-06
• Medicament comprising (-)-8-[(4-amino-1-méthylbutyl)amino]-5-(3,4-dichlorophénoxy)-6-méthoxy-4-méthylquinoline for the treatment of parasitic and opportunistic infections
  申请人：THE UNIVERSITY OF MISSISSIPPI

  公开号：EP0907363B1

  公开（公告）日：2007-05-23