4-氯甲基吡啶氮氧化物 | 70258-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-氯甲基吡啶氮氧化物
• 英文名称: 4-chloromethylpyridine-N-oxide
• 英文别名: 4-chloromethylpyridine N-oxide；4-(chloromethyl)pyridine N-oxide；4-(chloromethyl)pyridine-N-oxide；4-Chlormethyl-pyridin-N-oxid；4-(Chloromethyl)pyridine 1-oxide；4-(chloromethyl)-1-oxidopyridin-1-ium
• CAS: 70258-17-2
• 化学式: C₆H₆ClNO
• 分子量: 143.573
• InChiKey: YOCZJJNZPGJJRC-UHFFFAOYSA-N

物化性质

• 沸点：
  345.0±17.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-氯甲基吡啶氮氧化物 在 dirhodium tetraacetate 、 potassium carbonate 、 potassium iodide 、 tri tert-butylphosphoniumtetrafluoroborate 作用下， 以 乙二醇二甲醚 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 4-[3-hydroxy-1-[(1-oxidopyridin-1-ium-4-yl)methyl]-2-oxoindolin-3-yl]benzene-1-sulfonamide
  参考文献：
  名称：

  CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF

  摘要：

  Provided herein are novel compounds, such as a compound of Formula I or Formula A: or a salt thereof, wherein R1-R3, L1, R10, ring A and ring B have any of the values described in the specification, as well as compositions comprising the novel compounds herein. The compounds are typically carbonic anhydrase inhibitors and are useful for the prophylactic or therapeutic treatment of a disease or condition mediated by a carbonic anhydrase enzyme.

  公开号：

  WO2024124023A2
• 作为产物：
  描述：

  4-氯甲基吡啶盐酸盐 在 sodium hydroxide 、 间氯过氧苯甲酸 作用下， 以 水 、 二氯甲烷 为溶剂， 反应 17.0h， 以21%的产率得到4-氯甲基吡啶氮氧化物
  参考文献：
  名称：

  NOVEL COMPOUND HAVING 4-PYRIDYLALKYLTHIO GROUP AS SUBSTITUENT

  摘要：

  公开号：

  EP1602647B1

文献信息

• Non-nucleoside reverse transcriptase inhibitors
  申请人：Kestesz Denis John

  公开号：US20080146595A1

  公开（公告）日：2008-06-19

  The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 6a , R 6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

  本发明提供了用于治疗HIV感染、预防HIV感染、治疗AIDS或ARC的化合物。本发明的化合物具有如下式I所示的结构，其中R1、R2、R3、R4、R5a、R5b、R6a、R6b和X的定义如本文所述。本发明还公开了使用上述定义的化合物治疗HIV感染的方法，以及含有这些化合物的药物组合物。
• Bis-benzo or benzopyrido cyclohepta piperidene, piperidylidene and
  申请人：Schering Corporation

  公开号：US05422351A1

  公开（公告）日：1995-06-06

  Bis-benzo or benzopyrido piperidene, piperidylidene and piperazine compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof are disclosed, wherein Z represents --(C(R.sup.a).sub.2).sub.m --Y--(C(R.sup.a).sub.2).sub.n -- or ##STR2## The compounds of Formula I possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.

  本发明揭示了一种具有以下结构的双苯或苯并吡啶哌啶烯，哌啶基亚甲基和哌嗪类化合物的药用盐：其中Z代表--(C(R^a)_2)_m--Y--(C(R^a)_2)_n--或##STR2##。式I的化合物具有抗过敏和抗炎活性。还描述了制备和使用这些化合物的方法。
• Novel compounds having 4-pyridylalkylthio group as substituent
  申请人：Honda Takahiro

  公开号：US20060194836A1

  公开（公告）日：2006-08-31

  A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R 1 and R 2 , the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.

  本发明的目的是提供一种新的芳香性五元或六元杂环衍生物，其具有4-吡啶基烷硫基取代基或其盐，可作为药物使用。以下通式[I]所表示的化合物或其盐可用作治疗涉及血管生成或增强血管渗透性的疾病的治疗剂。其中，环“A”是苯环或芳香性五元或六元杂环，可以与环状烷基环融合，“B”是烷基，R1和R2，相同或不同，是H、OH、取代或未取代的烷氧基等，X和Y，相同或不同，分别是选择自H、卤素、OH、取代或未取代的烷氧基等的基团，p为0、1或2，q为0或1。
• Phenlypyridine carbonyl piperazine derivative
  申请人：——

  公开号：US20040192701A1

  公开（公告）日：2004-09-30

  The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. 1 (wherein R1, R2: hydrogen, a halogen, a lower alkyl, a lower alkoxy, or the like, R3, R4: hydrogen, a (substituted) lower alkyl, a halogen, or the like, R5: hydrogen, a lower alkyd, a lower alkoxycarbonyl, or the like, and n: 0 or 1).

  本发明涉及一种化合物，其由以下通式表示，并具有4型磷酸二酯酶抑制作用，以及其中间体化合物和用途。(其中R1、R2：氢、卤素、低碳基、低烷氧基等，R3、R4：氢、(取代)低碳基、卤素等，R5：氢、低烷基、低烷氧羰基等，n：0或1)。
• Phenylpyridinecarbonylpiperazinederivative
  申请人：Astellas Pharma Inc.

  公开号：US07196080B2

  公开（公告）日：2007-03-27

  The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein R1, R2: hydrogen, a halogen, a lower alkyl, a lower alkoxy, or the like, R3, R4: hydrogen, a (substituted) lower alkyl, a halogen, or the like, R5: hydrogen, a lower alkyl, a lower alkoxycarbonyl, or the like, and n: 0 or 1).

  本发明涉及一种化合物，该化合物由以下通式表示，并具有4型磷酸二酯酶抑制作用，以及其中间体化合物和用途。（其中R1、R2：氢、卤素、较低的烷基、较低的烷氧基或类似物，R3、R4：氢、（取代的）较低的烷基、卤素或类似物，R5：氢、较低的烷基、较低的烷氧羰基或类似物，n：0或1）。