α-(N-Boc)amino-N',N'-dimethyl-(4-methyl)phenylacetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-(N-Boc)amino-N',N'-dimethyl-(4-methyl)phenylacetamide
• 英文别名: tert-butyl N-[2-(dimethylamino)-1-(4-methylphenyl)-2-oxoethyl]carbamate
• 化学式: C₁₆H₂₄N₂O₃
• 分子量: 292.378
• InChiKey: DTAVVHQMELNXDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyl (phenylsulfonyl(p-tolyl)methyl)carbamate 在 caesium carbonate 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 25.0h， 生成 α-(N-Boc)amino-N',N'-dimethyl-(4-methyl)phenylacetamide
  参考文献：
  名称：

  Efficient synthesis of α-(N-Boc)aminoamides by addition of a carbamoylsilane to N-Boc-imines

  摘要：

  N,N-Dimethylcarbamoyl(trimethyl)silane reacted with N-Boc-imines in anhydrous benzene under catalysts-free conditions to afford N-Boc-protected alpha-amino amides in good yields (72-89%). The electronic property and the steric hindrance of substituent on the N-Boc-imines affected the reaction. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2016.10.066

文献信息

• Efficient synthesis of α-(N-Boc)aminoamides by addition of a carbamoylsilane to N-Boc-imines
  作者：Qilin Guo、Xueping Wen、Jianxin Chen

  DOI：10.1016/j.tet.2016.10.066

  日期：2016.12

  N,N-Dimethylcarbamoyl(trimethyl)silane reacted with N-Boc-imines in anhydrous benzene under catalysts-free conditions to afford N-Boc-protected alpha-amino amides in good yields (72-89%). The electronic property and the steric hindrance of substituent on the N-Boc-imines affected the reaction. (C) 2016 Elsevier Ltd. All rights reserved.