7-hydroxymethyl-4-methyl-coumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-hydroxymethyl-4-methyl-coumarin
• 英文别名: 7-Hydroxymethyl-4-methyl-cumarin；7-(Hydroxymethyl)-4-methylchromen-2-one；7-(hydroxymethyl)-4-methylchromen-2-one
• 化学式: C₁₁H₁₀O₃
• 分子量: 190.199
• InChiKey: UZTYZGPWQNEJJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,7-二甲基香豆素 在 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 作用下， 生成 7-hydroxymethyl-4-methyl-coumarin
  参考文献：
  名称：

  Lecocq, Annales de Chimie (Cachan, France), 1948, vol. <12> 3, p. 62,84

  摘要：

  DOI：

文献信息

• Intracellular Transfer Hydrogenation Mediated by Unprotected Organoiridium Catalysts
  作者：Sohini Bose、Anh H. Ngo、Loi H. Do

  DOI：10.1021/jacs.7b03872

  日期：2017.7.5

  In the present work, we show for the first time that the conversion of aldehydes to alcohols can be achieved using "unprotected" iridium transfer hydrogenation catalysts inside living cells. The reactions were observed in real time by confocal fluorescence microscopy using a Bodipy fluorogenic substrate. We propose that the reduced cofactor nicotinamide adenine dinucleotide (NADH) is a possible hydride source inside the cell based on studies using pyruvate as a cellular redox modulator. We expect that this biocompatible reductive chemistry will be broadly useful to practitioners working at the interface of chemistry and the life sciences.
• ENZYMES THAT CLEAVE NON-GLYCOSIDIC ETHER BONDS BETWEEN LIGNINS OR DERIVATIVES THEREOF AND SACCHARIDES
  申请人：Tethys Research LLC

  公开号：US20150368631A1

  公开（公告）日：2015-12-24

  The patent application relates to isolated polypeptides that specifically cleave non-glycosidic ether bonds between lignins or derivatives thereof and saccharides, and to cDNAs encoding the polypeptides. The patent application also relates to nucleic acid constructs, expression vectors and host cells comprising the cDNAs, as well as methods of producing and using the isolated polypeptides for treating pulp and biomass to increase soluble saccharide yield and enrich lignin fractions.
• US9796969B2
  申请人：——

  公开号：US9796969B2

  公开（公告）日：2017-10-24