5-(2-phenylmethoxyphenyl)-3H-1,3,4-oxadiazole-2-thione | 851664-25-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(2-phenylmethoxyphenyl)-3H-1,3,4-oxadiazole-2-thione
• CAS: 851664-25-0
• 化学式: C₁₅H₁₂N₂O₂S
• 分子量: 284.338
• InChiKey: CVGUKOJHOUCEKH-UHFFFAOYSA-N

物化性质

• 沸点：
  413.8±47.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苄基碘 、 5-(2-phenylmethoxyphenyl)-3H-1,3,4-oxadiazole-2-thione 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.33h， 生成 2-Benzylsulfanyl-5-(2-phenylmethoxyphenyl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles

  摘要：

  A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.014
• 作为产物：
  描述：

  2-苯氧基苯甲酸甲酯 在 氢氧化钾 、 一水合肼 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 11.0h， 生成 5-(2-phenylmethoxyphenyl)-3H-1,3,4-oxadiazole-2-thione
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles

  摘要：

  A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.014

文献信息

• Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles
  作者：Afshin Zarghi、Sayyed A. Tabatabai、Mehrdad Faizi、Avideh Ahadian、Parisa Navabi、Vahideh Zanganeh、Abbas Shafiee

  DOI：10.1016/j.bmcl.2005.02.014

  日期：2005.4

  A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. (c) 2005 Elsevier Ltd. All rights reserved.