3-propylpentane-1,5-diol | 69769-95-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-propylpentane-1,5-diol
• 英文别名: 3-propyl-pentane-1,5-diol；3-Propyl-pentan-1,5-diol；3-n-Propylpentan-1,5-diol
• CAS: 69769-95-5
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: WBJFJKPHFOAHPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-propylpentane-1,5-diol 在 氢溴酸 、 十六烷基三丁基溴化磷 作用下， 以 水 为溶剂， 以75%的产率得到3-propyl-1,5-dibromopentane
  参考文献：
  名称：

  3-取代-1,5-二溴戊烷作为杂环己烷前体的制备。

  摘要：

  研究了制备 3-取代的 1,5-二溴戊烷 I 及其直接前体（包括 3-取代的 1,5-戊二醇 VII 或 4-取代的四氢吡喃 VIII）的方法。这种二溴化物I是制备含有6元杂环的液晶衍生物的重要中间体。制备了四种二溴化物 1a-1d，在 3 位含有简单的烷基和更复杂的片段。3-丙基-和3-戊基-戊烷-1,5-二醇（2a，b）从戊二酸或丙二酸二酯开始制备，而四氢吡喃3c和3d从四氢-4H-吡喃-4-酮获得。讨论了每条路线的优缺点。二溴化物 1c 和 1d 用于制备锍两性离子 11c 和 11d。

  DOI：

  10.3762/bjoc.7.49
• 作为产物：
  描述：

  戊烯二酸二甲酯 在 copper(l) iodide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 3-propylpentane-1,5-diol
  参考文献：
  名称：

  Design, Synthesis, and Antipicornavirus Activity of 1-[5-(4-Arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one Derivatives

  摘要：

  A series of pyridylimidazolidinone derivatives was synthesized and tested in vitro against enterovirus 71 (EV71). On the basis of compound 33 (DBPR103), introduction of a methyl group at the 2- or 3-position of the linker between the imidazolidinone and the biphenyl resulted in markedly improved antiviral activity toward EV71 with IC50 values of 5.0 nM (24b) and 9.3 nM (14a), respectively. Increasing the branched chain to propyl resulted in a progressive decrease in activity, while inserting different heteroatoms entirely rendered the compound only weakly active. The introduction of a bulky group (cyclohexyl, phenyl, or benzyl) led to loss of activity against EV71. The 4-chlorophenyl moiety in 14a was replaced with bioisosteric groups such as oxadiazole (28a-d) or tetrazole (32a,b), dramatically improving anti-EV71 activity and selectivity indices. Compounds 14a, 24b, 28b, 28d, and 32a exhibited a strong activity against lethal EV71, and no apparent cellular toxicity was observed. Three of the more potent imidazolidinone compounds, 14a, 28b, and 32b, were subjected to a large group of picornaviruses to determine their spectrum of antiviral activity.

  DOI：

  10.1021/jm050033v

文献信息

• NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
  申请人：S&T Global Inc.

  公开号：US20130210704A1

  公开（公告）日：2013-08-15

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

  本发明涉及公式(I)的化合物或其药学上可接受的盐，其中符号如规范中所定义；以及包含该化合物的制药组合物，用于治疗或预防病毒感染、炎症、干眼症、中枢神经系统疾病、心血管疾病、癌症、肥胖症、糖尿病、肌肉营养不良和脱发的方法。
• LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT
  申请人：Merck Patent GmbH

  公开号：US20150252265A1

  公开（公告）日：2015-09-10

  The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerizable component. The polymerizable component comprises self-aligning, polymerizable mesogens (polymerizable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the LC medium without alignment layers. The invention discloses novel structures for self-alignment additives which have a certain position of the functional groups.

  本发明涉及具有正或负介电各向异性的液晶介质（LC介质），包括低分子量成分和可聚合成分。可聚合成分包括自排列、可聚合的介质基（可聚合自排列添加剂），可在液晶显示器（LC显示器）的表面或细胞壁处实现LC介质的同向（垂直）排列。因此，本发明还包括具有同向排列的LC介质的LC显示器，而无需排列层。本发明还揭示了自排列添加剂的新结构，其具有某些功能基团的位置。
• A polyester laminated film
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0379190A2

  公开（公告）日：1990-07-25

  A polyester laminated film with excellent sealing ability is provided. The polyester laminated film comprises a base film of a polyester resin and a sealing film of a polyester composition, said sealing film being disposed on at least one side of said base film, wherein the sealing energy, which is measured when two pieces of said laminated films are joined together with the respective sealing films facing each other, is 300 g.cm/15 mm or more.

  本发明提供了一种具有优异密封能力的聚酯复合膜。该聚酯复合膜由聚酯树脂基膜和聚酯成分密封膜组成，所述密封膜至少位于所述基膜的一侧，其中，当两片所述复合膜连接在一起，且各自的密封膜面对面时，测得的密封能为 300 g.cm/15 mm 或更高。
• An aqueous dispersion
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0520266A1

  公开（公告）日：1992-12-30

  An aqueous dispersion suitable for use as various coatings is provided. The dispersion includes polyester resin (A), a water soluble organic compound (B), water (C), and a neutralizer (D). The poylester resin has an acid number of 50 equivalents/10⁶ g or more. The polycarboxylic acid component of the resin contains aromatic dicarboxylic acid having no metal sulfonate groups in an amount in the range of 50 to 99.99 mole percent, and dicarboxylic acid having a metal sulfonate group in an amount in the range of 0.01 to 20 mole percent based on the total moles of the polycarboxylic acid component. The polyol component of the resin contains diol in an amount in the range of 30 to 100 mole percent based on the total moles of the polyol component. The diol has an alkyl group with 1 to 3 carbon atoms on a side chain, and the total number of carbon atoms in the diol is 6 to 25. The water soluble organic compound has a boiling point in the range of 60 to 250°C. The components (A), (B), and (C) are contained in the dispersion in an amount in the range of 1 to 70 percent by weight, 0 to 69 percent by weight, and 9 to 99 percent by weight, respectively. Further, the components (A), (B), (C), and (D) satisfy the following expressions (1) and (2):B/(B + C) (weight ratio) = 0-0.7D/A (equivalent ratio) = 0.1-20

  提供了一种适合用作各种涂料的水性分散体。分散体包括聚酯树脂（A）、水溶性有机化合物（B）、水（C）和中和剂（D）。聚酯树脂的酸值为 50 当量/10⁶ g 或以上。树脂中的聚羧酸组分含有不含金属磺酸基的芳香族二羧酸，含量在 50 至 99.99 摩尔%之间，以及含有金属磺酸基的二羧酸，含量在 0.01 至 20 摩尔%之间（以聚羧酸组分的总摩尔数计）。树脂的多元醇组分中含有二元醇，其含量为多元醇组分总摩尔数的 30 至 100 摩尔%。二元醇的侧链上有 1 至 3 个碳原子的烷基，二元醇中的碳原子总数为 6 至 25。水溶性有机化合物的沸点范围为 60 至 250°C。分散液中组分（A）、（B）和（C）的含量分别为 1%至 70%（重量百分比）、0%至 69%（重量百分比）和 9%至 99%（重量百分比）。此外，组分（A）、（B）、（C）和（D）满足以下表达式（1）和（2）：B/（B + C）（重量比）= 0-0.7D/A（当量比）= 0.1-20
• Adhesive resin composition and adhesive film
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0911353A1

  公开（公告）日：1999-04-28

  An adhesive resin composition comprising polyester polyurethane having a number average molecular weight of 8,000 - 100,000 and an epoxy resin having two or more epoxy groups per molecule, said polyester polyurethane having an acid value of 100 - 1,000 equivalent/ 106 g and the proportion of polyester polyurethane having a molecular weight of not more than 5,000 is not more than 20 wt% and an adhesive film obtained from the adhesive resin composition. The adhesive resin composition and the adhesive film of the present invention have a longer working life and are superior in adhesive property, heat resistance and water resistance.

  一种粘合剂树脂组合物，由平均分子量为 8,000 - 100,000 的聚酯聚氨酯和每个分子具有两个或两个以上环氧基团的环氧树脂组成，所述聚酯聚氨酯的酸值为 100 - 1,000 当量/106克，分子量不超过 5,000 的聚酯聚氨酯的比例不超过 20 wt%，以及由该粘合剂树脂组合物制成的粘合膜。本发明的粘合剂树脂组合物和粘合剂薄膜的工作寿命更长，粘合性能、耐热性和耐水性更优越。