N,N-二乙基-2-甲氧基-5-硝基苯胺 | 4513-19-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N-二乙基-2-甲氧基-5-硝基苯胺
• 英文名称: 3-(diethylamino)-4-methoxynitrobenzene
• 英文别名: N,N-Diethylamino-2-methoxy-5-nitroanilin；Benzenamine, N,N-diethyl-2-methoxy-5-nitro-；N,N-diethyl-2-methoxy-5-nitroaniline
• CAS: 4513-19-3
• 化学式: C₁₁H₁₆N₂O₃
• 分子量: 224.26
• InChiKey: VKWWGWYGBUWOOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  N,N-二乙基-2-甲氧基-5-硝基苯胺 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 3-N,N-diethylamino-4-methoxy-aniline
  参考文献：
  名称：

  Watanabe, Tetsushi; Shiozawa, Tatsushi; Takahashi, Yoshifumi, Mutagenesis, 2002, vol. 17, # 4, p. 293 - 299

  摘要：

  DOI：
• 作为产物：
  描述：

  溴乙烷 、 2-氨基-4-硝基苯甲醚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以94%的产率得到N,N-二乙基-2-甲氧基-5-硝基苯胺
  参考文献：
  名称：

  Watanabe, Tetsushi; Shiozawa, Tatsushi; Takahashi, Yoshifumi, Mutagenesis, 2002, vol. 17, # 4, p. 293 - 299

  摘要：

  DOI：

文献信息

• A curcumin-based NIR fluorescence probe for detection of amyloid-beta (Aβ) plaques in Alzheimer's disease
  作者：Guofu Si、Shujie Zhou、Guoyong Xu、Jiafeng Wang、Baoxing Wu、Shuangsheng Zhou

  DOI：10.1016/j.dyepig.2018.12.003

  日期：2019.4

  Amyloid-beta (A beta) peptide as one of the main components of senile plaques is closely related to the onset and progression of incurable Alzheimer's disease (AD). In recent years, it is reported that curcumin derivatives have been used as the near-infrared (NIR) fluorescence imaging probes of A beta plaques for the early diagnosis of AD. To further develop a curcumin-based NIR fluorescent probe for A beta plaques, in this work, we have synthesized three novel curcumin-based NIR Dyes. Among them, the curcumin derivative Dye 2 showed a significant enhancement in its fluorescence intensity (lambda em, 635 nm; 19.5-fold increase in quantum yield, Phi = 0.36; K-d, 1.13 mu M) after binding to A beta plaques. Additionally, in vitro and in vivo fluorescence imaging of A beta plaques strained with Dye 2 confirmed that the compound was a potential probe to detect A beta plaques in AD. This work opens a perspective to rationally design novel curcumin-based NIR compound for A beta detection.
• Watanabe, Tetsushi; Shiozawa, Tatsushi; Takahashi, Yoshifumi, Mutagenesis, 2002, vol. 17, # 4, p. 293 - 299
  作者：Watanabe, Tetsushi、Shiozawa, Tatsushi、Takahashi, Yoshifumi、Takahashi, Tomoyuki、Terao, Yoshiyasu、Nukaya, Haruo、Takamura, Takeji、Sawanishi, Hiroyuki、Ohe, Takeshi、Hirayama, Teruhisa、Wakabayashi, Keiji

  DOI：——

  日期：——