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(E)-1-{3-[(E)-(2-bromo-5-methoxybenzylidene)amino]-4-methoxyphenyl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

中文名称
——
中文别名
——
英文名称
(E)-1-{3-[(E)-(2-bromo-5-methoxybenzylidene)amino]-4-methoxyphenyl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
英文别名
——
(E)-1-{3-[(E)-(2-bromo-5-methoxybenzylidene)amino]-4-methoxyphenyl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one化学式
CAS
——
化学式
C27H26BrNO6
mdl
——
分子量
540.411
InChiKey
DKNBTSCINKUBML-JFFKFGFUSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    6.14
  • 重原子数:
    35.0
  • 可旋转键数:
    10.0
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.19
  • 拓扑面积:
    75.58
  • 氢给体数:
    0.0
  • 氢受体数:
    7.0

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    参考文献:
    名称:
    Design, synthesis and biological evaluation of paralleled Aza resveratrol–chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury
    摘要:
    Acute lung injury (ALI) is a major cause of acute respiratory failure in critically-ill patients. It has been reported that both resveratrol and chalcone derivatives could ameliorate lung injury induced by inflammation. A series of paralleled Aza resveratrol-chalcone compounds (5a-5m, 6a-6i) were designed, synthesized and screened for anti-inflammatory activity. A majority showed potent inhibition on the IL-6 and TNF-alpha expression-stimulated by LPS in macrophages, of which compound 6b is the most potent analog by inhibition of LPS-induced IL-6 release in a dose-dependent manner. Moreover, 6b exhibited protection against LPS-induced acute lung injury in vivo. These results offer further insight into the use of Aza resveratrol-chalcone compounds for the treatment of inflammatory diseases, and the use of compound 6b as a lead compound for the development of anti-ALI agents. (C) 2015 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2015.05.030
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文献信息

  • Design, synthesis and biological evaluation of paralleled Aza resveratrol–chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury
    作者:Wenbo Chen、Xiangting Ge、Fengli Xu、Yali Zhang、Zhiguo Liu、Jialing Pan、Jiao Song、Yuanrong Dai、Jianmin Zhou、Jianpeng Feng、Guang Liang
    DOI:10.1016/j.bmcl.2015.05.030
    日期:2015.8
    Acute lung injury (ALI) is a major cause of acute respiratory failure in critically-ill patients. It has been reported that both resveratrol and chalcone derivatives could ameliorate lung injury induced by inflammation. A series of paralleled Aza resveratrol-chalcone compounds (5a-5m, 6a-6i) were designed, synthesized and screened for anti-inflammatory activity. A majority showed potent inhibition on the IL-6 and TNF-alpha expression-stimulated by LPS in macrophages, of which compound 6b is the most potent analog by inhibition of LPS-induced IL-6 release in a dose-dependent manner. Moreover, 6b exhibited protection against LPS-induced acute lung injury in vivo. These results offer further insight into the use of Aza resveratrol-chalcone compounds for the treatment of inflammatory diseases, and the use of compound 6b as a lead compound for the development of anti-ALI agents. (C) 2015 Elsevier Ltd. All rights reserved.
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