双酚 A (2,3-二羟基丙基)缩水甘油醚 | 76002-91-0

• 物质功能分类: 分析化学 - 标准品 - 食品和饮料标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双酚 A (2,3-二羟基丙基)缩水甘油醚
• 中文别名: 双酚A(2,3-二羟基丙基)缩水甘油醚；双酚A(2,3-二羟丙基)甘油醚
• 英文名称: 2-[4-(2,3-epoxypropanyloxy)phenyl-2-4-(2,3-dihydroxypropanyloxy)phenyl]propane
• 英文别名: bisphenol A [2,3-dihydroxypropyl] glycidyl ether；3-(4-(1-(4-(2,3-Epoxypropoxy)phenyl)-1-methylethyl)phenoxy)propane-1,2-diol；3-[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]propane-1,2-diol
• CAS: 76002-91-0
• 化学式: C₂₁H₂₆O₅
• 分子量: 358.434
• InChiKey: NBLIPZBCGXIEFO-UHFFFAOYSA-N

物化性质

• 沸点：
  553.0±50.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S28,S37/39
• 危险类别码：
  R36/38,R43
• WGK Germany：
  3
• 海关编码：
  2910900090

反应信息

• 作为反应物：
  描述：

  双酚 A (2,3-二羟基丙基)缩水甘油醚 在 水 作用下， 以 四氢呋喃 为溶剂， 生成 丙二酚四异丙醇醚
  参考文献：
  名称：

  Interaction of a Vinylic Organosol Used as Can Coating with Solvents and Food Simulants

  摘要：

  Metal cans are often protected from corrosion by vinylic organosol coatings, made from PVC and epoxyphenolic (EP) resins. Using electron spin resonance, BADGE, a monomer of EP, was shown to plasticize PVC. Optimization of extraction allowed extraction of 4 mg of BADGE/dm(2), so vinylic organosols appear to be worst-case coatings. Comparison of behavior between BADGE and a paramagnetic probe revealed that these compounds were trapped to a large extent in the crosslinked EP network and could not migrate at 40 degrees C. Contact with triglycerides, which plasticize the coating, induced high migration of BADGE. Neither isooctane nor ethanol could mimic fats, in contrast to isooctane/tert-butyl acetate mixtures. In aqueous foodstuffs, BADGE hydrolyzed into a monoepoxide and then into a bisdiol. The total amount of toxicologically relevant epoxides over shelf life was shown to reach a maximum value within 3 weeks at 40 degrees C, at very low levels, whatever the aqueous food simulant. After sterilization at 120 degrees C (20 min), the level of BADGE in the migrate is very low, whereas up to 2 mg of hydrolysis products is found in the liquid/dm(2). During further storage at 40 degrees C, the amount of epoxides rapidly decreases.

  DOI：

  10.1021/jf9708913
• 作为产物：
  描述：

  2,2-双-(4-甘胺氧苯)丙烷 在 水 作用下， 以 四氢呋喃 为溶剂， 生成 双酚 A (2,3-二羟基丙基)缩水甘油醚
  参考文献：
  名称：

  Interaction of a Vinylic Organosol Used as Can Coating with Solvents and Food Simulants

  摘要：

  Metal cans are often protected from corrosion by vinylic organosol coatings, made from PVC and epoxyphenolic (EP) resins. Using electron spin resonance, BADGE, a monomer of EP, was shown to plasticize PVC. Optimization of extraction allowed extraction of 4 mg of BADGE/dm(2), so vinylic organosols appear to be worst-case coatings. Comparison of behavior between BADGE and a paramagnetic probe revealed that these compounds were trapped to a large extent in the crosslinked EP network and could not migrate at 40 degrees C. Contact with triglycerides, which plasticize the coating, induced high migration of BADGE. Neither isooctane nor ethanol could mimic fats, in contrast to isooctane/tert-butyl acetate mixtures. In aqueous foodstuffs, BADGE hydrolyzed into a monoepoxide and then into a bisdiol. The total amount of toxicologically relevant epoxides over shelf life was shown to reach a maximum value within 3 weeks at 40 degrees C, at very low levels, whatever the aqueous food simulant. After sterilization at 120 degrees C (20 min), the level of BADGE in the migrate is very low, whereas up to 2 mg of hydrolysis products is found in the liquid/dm(2). During further storage at 40 degrees C, the amount of epoxides rapidly decreases.

  DOI：

  10.1021/jf9708913

文献信息

• [EN] DIGLYCIDIC ETHER DERIVATIVE THERAPEUTICS AND METHODS FOR THEIR USE<br/>[FR] PRODUITS THÉRAPEUTIQUES DÉRIVÉS D'ÉTHERS DIGLYCIDIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BRITISH COLUMBIA CANCER AGENCY

  公开号：WO2010000066A1

  公开（公告）日：2010-01-07

  This invention provides compound having a structure of Formula I or Formula II. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

  这项发明提供了具有化学结构为式I或式II的化合物。还提供了这些化合物用于治疗各种适应症，包括前列腺癌的用途，以及涉及这些化合物的治疗方法。
• ESTER DERIVATIVES OF ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE
  申请人：The University of British Columbia

  公开号：US20140335080A1

  公开（公告）日：2014-11-13

  Compounds having a structure of Structure I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , J 1 , J 2 , X, Z, n 1 and n 2 are as defined herein, and wherein at least one of R 1 , R 2 or R 3 is an alkyl, alkenyl, aryl or aralkyl ester, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.

  具有结构I的化合物：或其药学上可接受的盐、互变异构体或立体异构体，其中R1、R2、R3、R4、R5、J1、J2、X、Z、n1和n2如本文所定义，并且其中至少有一个R1、R2或R3是烷基、烯基、芳基或芳基酯。提供了这些化合物用于治疗各种适应症，包括前列腺癌的用途，以及涉及这些化合物的治疗方法。
• Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom
  申请人：Dow Global Technologies Inc.

  公开号：US06646102B2

  公开（公告）日：2003-11-11

  A process for manufacturing an &agr;-dihydroxy derivative from an aryl allyl ether wherein such &agr;-dihydroxy derivative can be used to prepare an &agr;-halohydrin intermediate and an epoxy resin prepared therefrom including epoxidizing an &agr;-halohydrin intermediate produced from a halide substitution of an &agr;-dihydroxy derivative which has been obtained by a dihydroxylation reaction of an aryl allyl ether in the presence of an oxidant or in the presence of an oxidant and a catalyst.

  从芳基烯丙基醚制备α-二羟基衍生物的制造过程，其中该α-二羟基衍生物可用于制备α-卤代醇中间体和由此制备的环氧树脂，包括在氧化剂存在下或在氧化剂和催化剂存在下通过卤代物取代从α-二羟基衍生物脱氢反应中获得的α-卤代醇中间体的环氧化。
• DRUCKTINTE, VORZUGSWEISE 3D-DRUCKTINTE, BRILLENGLAS UND VERFAHREN ZUR HERSTELLUNG EINES BRILLENGLASES
  申请人：Carl Zeiss Vision International GmbH

  公开号：EP3273290A1

  公开（公告）日：2018-01-24

  Die vorliegende Erfindung betrifft eine Drucktinte, vorzugsweise 3D-Drucktinte, wobei die Drucktinte wenigstens eine strahlungshärtbare Komponente und optional wenigstens ein Farbmittel umfasst und die strahlungshärtbare Komponente wenigstens ein Monomer aus der Gruppe bestehend aus (Meth)acrylatmonomeren, Epoxymonomeren, Vinylmonomeren und Allylmonomeren umfasst. Die Erfindung betrifft außerdem die Verwendung einer Drucktinte, vorzugsweise 3D-Drucktinte, zur Herstellung eines Brillenglases. Weiterhin betrifft die Erfindung ein Brillenglas umfassend wenigstens eine farb- und/oder effektgebende Lage, wobei das Brillenglas erhältlich ist durch einheitenweise Anordnung wenigstens eines Volumenelements einer Drucktinte, vorzugsweise 3D-Drucktinte, umfassend wenigstens eine strahlungshärtbare Komponente und die farb- und/oder effektgebende Lage wenigstens ein Volumenelement einer Drucktinte mit wenigstens einem Farbmittel umfasst.

  本发明涉及一种印刷油墨，最好是三维印刷油墨，其中印刷油墨包括至少一种辐射固化组分和可选的至少一种着色剂，辐射固化组分包括至少一种单体，该单体来自由（甲基）丙烯酸酯单体、环氧单体、乙烯基单体和烯丙基单体组成的组。本发明还涉及使用印刷油墨（最好是 3D 印刷油墨）制造眼镜片。本发明还涉及一种包含至少一个着色层和/或效果提供层的眼镜片，其中眼镜片可通过在单元中排列至少一个包含至少一种辐射固化成分的印刷油墨（最好是三维印刷油墨）的体积元素而获得，着色层和/或效果提供层包含至少一个含有至少一种着色剂的印刷油墨的体积元素。
• Solid insulation material
  申请人：Siemens Aktiengesellschaft

  公开号：US10778058B2

  公开（公告）日：2020-09-15

  Various embodiments may include a solid insulation material, e.g. in tape form, the use thereof in a vacuum impregnation process, and/or an insulation system produced therewith and also an electrical machine having the insulation system, for the medium- and high-voltage sector. Some examples include rotating electrical machines in the medium- and high-voltage sector and also semifinished products for electrical switchgear. The solid insulation material and the insulation system produced therewith are characterized in that it can be produced in an anhydride-free manner, wherein the curing catalyst is, for example, an adduct of a 1H-imidazole and/or 1H-imidazole derivative with a compound containing oxirane groups.

  各种实施方案可包括一种固体绝缘材料，例如带状材料，其在真空浸渍工艺中的使用，和/或用其生产的绝缘系统，以及具有该绝缘系统的中压和高压领域的电机。例如，中压和高压领域的旋转电机，以及用于电气开关设备的半成品。该固体绝缘材料和用其生产的绝缘系统的特点是可以用无酐方式生产，其中固化催化剂例如是 1H-imidazole 和/或 1H-imidazole 衍生物与含有环氧乙烷基团的化合物的加合物。