7-(acetylamino)tetralone | 58161-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-(acetylamino)tetralone
• 英文别名: 7-Acetamino-tetralon-(1)；7-Acetamido-1-tetralon；7-Acetamido-tetralon-(1)；N-(8-oxo-5,6,7,8-tetrahydro-[2]naphthyl)-acetamide；N-(8-Oxo-5,6,7,8-tetrahydro-[2]naphthyl)-acetamid；N-(5,6,7,8-Tetrahydro-8-oxo-2-naphthyl)acetamide；7-acetylamino-1-tetralone；7-acetamido-1-tetralone；N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide；N-(8-oxo-6,7-dihydro-5H-naphthalen-2-yl)acetamide
• CAS: 58161-21-0
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: GWITZVQYQPVXQC-UHFFFAOYSA-N

物化性质

• 熔点：
  161.0-161.1 °C
• 沸点：
  427.8±34.0 °C(Predicted)
• 密度：
  1.225±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  7-(acetylamino)tetralone 在 palladium on activated charcoal 氢气 、 羟胺 作用下， 生成 N-(8-Amino-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetamide
  参考文献：
  名称：

  FR2260339

  摘要：

  公开号：
• 作为产物：
  描述：

  4-(乙酰氨基)苯丁酸 在 硫酸 作用下， 生成 7-(acetylamino)tetralone
  参考文献：
  名称：

  Monoquaternary neuromuscular blocking agents based on 1-tetralone and 1-indanone

  摘要：

  The preparation of three isomeric 1-tetralone hydrozones 4 and three isomeric 1-indanone hydrozones 5 possessing a single quaternary ammonium center is described. Several of the compounds possessed significant neuromuscular blocking activity, and two approached suxamethonium in potency. 1H NMR evidence obtained from a study of the N,N-dimethylhydrozones indicated that the hydrazones adopted an E configuration in solution.

  DOI：

  10.1021/jm00226a004

文献信息

• Melanin concentrating hormone antagonist
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US07115750B1

  公开（公告）日：2006-10-03

  A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.

  一种黑色素浓缩激素拮抗剂，包括以下式的化合物： 其中Ar1是可能具有取代基团的环状基团； X是具有1到6个原子的主链的间隔物； Y是键或具有1到6个原子的主链的间隔物； Ar是可能与4到8个成员的非芳香环融合的单环芳香环，并且可能具有进一步的取代基团； R1和R2分别是氢原子或可能具有取代基团的碳氢基团；R1和R2，连同相邻的氮原子，可能形成可能具有取代基团的含氮杂环；R2可能与Ar一起形成螺环；或者R2，连同相邻的氮原子和Y，可能形成可能具有取代基团的含氮杂环；或其盐； 该化合物可用作预防或治疗肥胖等疾病的药剂。
• Synthesis and biological evaluation of substituted benzo[h]cinnolinones and 3H-benzo[6,7]cyclohepta[1,2-c]pyridazinones: higher homologs of the antihypertensive and antithrombotic 5H-indeno[1,2-c]pyridazinones
  作者：Giorgio Cignarella、Daniela Barlocco、Gerard A. Pinna、Mario Loriga、Maria M. Curzu、Odoardo Tofanetti、Mauro Germini、Pietro Cazzulani、Ennio Cavalletti

  DOI：10.1021/jm00130a009

  日期：1989.10

  that of acetylsalicylic acid, most of the benzo[h]cinnolinones exhibited significant antihypertensive, inotropic, and antithrombotic properties. In this respect, the 8-amino (3b) and 8-acetylamino (3c) together with the 4,4a-dehydro analogue of 3c (11) were found to possess the most potent and long-lasting antihypertensive activity. In particular, the dextro isomer of 3c was more active than the racemic

  几个取代的苯并[h]肉桂酮3和3H-苯并[6,7]环庚[1,2-c]哒嗪酮4被设计为5H-茚并[1,2-c]哒嗪酮2的较不刚性的同类物。合成并测试为抗高血压药，正性肌力药，抗血栓药，抗炎药和抗溃疡药。尽管七元环衍生物仅显示出与乙酰水杨酸相当的抗血栓形成特性，但大多数苯并[h]肉桂醇酮显示出显着的抗高血压，正性肌力和抗血栓形成特性。在这方面，发现8-氨基（3b）和8-乙酰氨基（3c）以及3c（11）的4,4a-脱氢类似物具有最有效和最持久的降压活性。特别地，3c的右旋异构体比消旋形式更具活性，心动过速效应更低。
• Iodine(III)-Mediated Ring Contraction Reactions: Synthesis of Oxygen- and Nitrogen-Substituted Indanes
  作者：Anees Ahmad、Luiz F. Silva Júnior

  DOI：10.5935/0103-5053.20160065

  日期：——

  The synthesis of oxygen-and nitrogen-substituted indanes was successfully performed by iodine(III)-mediated ring contraction of 1,2-dihydronaphthalenes. Acetoxy and benzoyloxy alkenes afforded indanes in 60-71% yield, irrespective of their position on aromatic ring. Similarly, the nitrogen containing substrates protected with 9-fluorenylmethyloxycarbonyl (Fmoc) and benzoyl (Bz) groups smoothly undergoes ring contraction giving indanes in 64-77% yield. The tosyl-protected substrate resulted only in addition products.
• 945. Hydrogen transfer. Part XIX. Dehydrogenation of substituted 1,2-dihydronaphthalenes by quinones, and the correlation of donor reactivity with the nature of substituents
  作者：L. M. Jackman、D. T. Thompson

  DOI：10.1039/jr9610004794

  日期：——
• Barlocco; Pinna; Carboni, Il Farmaco, 1989, vol. 44, # 10, p. 967 - 974
  作者：Barlocco、Pinna、Carboni、Cipolla

  DOI：——

  日期：——