N-(5,6-二氢-2-萘基)-乙酰胺 | 915084-86-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-(5,6-二氢-2-萘基)-乙酰胺
• 英文名称: N-(5,6-dihydronaphthalen-2-yl)acetamide
• 英文别名: 6-Acetamido-1,2-dihydronaphthalin；N-(5,6-Dihydro-2-naphthalenyl)acetamide
• CAS: 915084-86-5
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: RQDSKZPCOMDYBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(5,6-二氢-2-萘基)-乙酰胺 在 邻四氯苯醌 作用下， 以 邻二氯苯 为溶剂， 生成 N-乙醯萘胺
  参考文献：
  名称：

  945.氢转移。第十九部分。取代的1,2-二氢萘被醌脱氢，以及供体反应性与取代基性质的关系

  摘要：

  DOI：

  10.1039/jr9610004794
• 作为产物：
  描述：

  7-氨基-1-四氢萘酮 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 N-(5,6-二氢-2-萘基)-乙酰胺
  参考文献：
  名称：

  Iodine(III)-Mediated Ring Contraction Reactions: Synthesis of Oxygen- and Nitrogen-Substituted Indanes

  摘要：

  The synthesis of oxygen-and nitrogen-substituted indanes was successfully performed by iodine(III)-mediated ring contraction of 1,2-dihydronaphthalenes. Acetoxy and benzoyloxy alkenes afforded indanes in 60-71% yield, irrespective of their position on aromatic ring. Similarly, the nitrogen containing substrates protected with 9-fluorenylmethyloxycarbonyl (Fmoc) and benzoyl (Bz) groups smoothly undergoes ring contraction giving indanes in 64-77% yield. The tosyl-protected substrate resulted only in addition products.

  DOI：

  10.5935/0103-5053.20160065

文献信息

• Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
  申请人：Incyte Corporation

  公开号：EP2426129A1

  公开（公告）日：2012-03-07

  The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines (I) and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了杂芳基取代的吡咯并[2,3-b]吡啶(I)和杂芳基取代的吡咯并[2,3-b]嘧啶，它们能调节 Janus 激酶的活性，可用于治疗与 Janus 激酶活性有关的疾病，例如包括免疫相关疾病、皮肤病、骨髓增生性疾病、癌症和其他疾病。
• PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR
  申请人：Incyte Holdings Corporation

  公开号：EP3466953B1

  公开（公告）日：2021-02-03
• Iodine(III)-Mediated Ring Contraction Reactions: Synthesis of Oxygen- and Nitrogen-Substituted Indanes
  作者：Anees Ahmad、Luiz F. Silva Júnior

  DOI：10.5935/0103-5053.20160065

  日期：——

  The synthesis of oxygen-and nitrogen-substituted indanes was successfully performed by iodine(III)-mediated ring contraction of 1,2-dihydronaphthalenes. Acetoxy and benzoyloxy alkenes afforded indanes in 60-71% yield, irrespective of their position on aromatic ring. Similarly, the nitrogen containing substrates protected with 9-fluorenylmethyloxycarbonyl (Fmoc) and benzoyl (Bz) groups smoothly undergoes ring contraction giving indanes in 64-77% yield. The tosyl-protected substrate resulted only in addition products.
• 945. Hydrogen transfer. Part XIX. Dehydrogenation of substituted 1,2-dihydronaphthalenes by quinones, and the correlation of donor reactivity with the nature of substituents
  作者：L. M. Jackman、D. T. Thompson

  DOI：10.1039/jr9610004794

  日期：——