6-undecanethiol | 935458-45-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: 6-undecanethiol
• 英文别名: Undecane-6-thiol
• CAS: 935458-45-0
• 化学式: C₁₁H₂₄S
• 分子量: 188.378
• InChiKey: YDGJYPOBGPVUFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-undecanethiol 在 过氧乙酸 、 溶剂黄146 作用下， 反应 2.0h， 生成 6-undecanesulfonic acid methyl ester
  参考文献：
  名称：

  Foldamers as Reactive Sieves:  Reactivity as a Probe of Conformational Flexibility

  摘要：

  A series of m-phenyleneethynylene (mPE) oligomers modified with a dimethylaminopyridine (DMAP) unit were treated with methyl sulfonates of varying sizes and shapes, and the relative reactivities were measured by UV spectrophotometry. Using a small-molecule DMAP analogue as a reference, each of the methyl sulfonates was shown to react at nearly identical rate. In great contrast, oligomers that are long enough to fold, and hence capable of binding the methyl sulfonate, experience rate enhancements of 18-1600-fold relative to that of the small-molecule analogue, depending on the type of alkyl chain attached to the guest. Three different oligomer lengths were studied, with the longest oligomers exhibiting the fastest rate and greatest substrate specificity. Even large, bulky guests show slightly enhanced methylation rates compared to that with the reference DMAP, which suggests a dynamic nature to the oligomer's binding cavity. Several mechanistic models to describe this behavior are discussed.

  DOI：

  10.1021/ja067670a
• 作为产物：
  描述：

  二正戊基酮 在 正丁基锂 、 对甲苯磺酸 作用下， 以 乙醚 、 苯 为溶剂， 生成 6-undecanethiol
  参考文献：
  名称：

  Foldamers as Reactive Sieves:  Reactivity as a Probe of Conformational Flexibility

  摘要：

  A series of m-phenyleneethynylene (mPE) oligomers modified with a dimethylaminopyridine (DMAP) unit were treated with methyl sulfonates of varying sizes and shapes, and the relative reactivities were measured by UV spectrophotometry. Using a small-molecule DMAP analogue as a reference, each of the methyl sulfonates was shown to react at nearly identical rate. In great contrast, oligomers that are long enough to fold, and hence capable of binding the methyl sulfonate, experience rate enhancements of 18-1600-fold relative to that of the small-molecule analogue, depending on the type of alkyl chain attached to the guest. Three different oligomer lengths were studied, with the longest oligomers exhibiting the fastest rate and greatest substrate specificity. Even large, bulky guests show slightly enhanced methylation rates compared to that with the reference DMAP, which suggests a dynamic nature to the oligomer's binding cavity. Several mechanistic models to describe this behavior are discussed.

  DOI：

  10.1021/ja067670a

文献信息

• CROSS-LINKERS AND THEIR USES
  申请人：ImmunoGen, Inc.

  公开号：US20150352223A1

  公开（公告）日：2015-12-10

  Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.

  带电或前充电的交联基团和细胞结合剂和药物的共轭物，包括带电或前充电的交联基团，以及制备方法。
• [EN] HETEROCYCLIC COMPOUNDS WITH WORKING MEMORY ENHANCING ACTIVITY<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES À ACTIVITÉ AMÉLIORANT LA MÉMOIRE DE TRAVAIL
  申请人：RED BULL GMBH

  公开号：WO2016023997A1

  公开（公告）日：2016-02-18

  The present invention relates to a chemical compound having the general formula (I): wherein R1 and R2 are, equal or independently, aryl, heteroaryl; wherein RTA is a 2-1,3-, or 4- 1,3- or 5-1,3-thiazole ring and its use in for improving; the short term memory and/or the working memory.

  本发明涉及一种具有通式(I)的化合物，其中R1和R2分别或相等地为芳基、杂环芳基；其中RTA为2-1、3-、或4-1、3-或5-1、3-噻唑环，以及其在改善短期记忆和/或工作记忆方面的用途。
• Resin and its use in converting morphine to codeine
  申请人：——

  公开号：US20020082357A1

  公开（公告）日：2002-06-27

  A resin and its use as a methylating agent. One embodiment is a resin comprising a solid support and cationic methylated sulfonium, sulfoxonium, selenonium or phosphonium salts immobilized on the solid support. Another embodiment is the use of the resin as a methylating agent, for example in the conversion of morphine to codeine.

  一种树脂及其用作甲基化剂。其中一种实施方式是包括固体支撑物和阳离子甲基化的磺鎓、磺氧鎓、硒鎓或膦鎓盐固定在固体支撑物上的树脂。另一种实施方式是将该树脂用作甲基化剂，例如在吗啡转化为可待因的过程中。
• Heterocyclic compounds with working memory enhancing activity
  申请人：Red Bull GmbH

  公开号：EP2985279A1

  公开（公告）日：2016-02-17

  The present invention relates to a chemical compound having the general formula (I): wherein R1 and R2 are, equal or independently, aryl or heteroaryl; and RTA is a 2-1,3-, or 4-1,3- or 5-1,3-thiazole ring with the general Formula (IIa) or a 1,3,4-thiadiazole ring which can also be substituted. The invention also relates to said compound according to formula (I) for use in treating cognative function defects, in particular for use in improving the working memory and/or the short-term memory. Further, the invention relates to processes for preparing compounds according to formula (I).

  本发明涉及一种具有通式（I）的化合物： 其中 R1 和 R2 是相同或独立的芳基或杂芳基；RTA 是通式（IIa）的 2-1,3-或 4-1,3-或 5-1,3-噻唑环或也可被取代的 1,3,4-噻二唑环。 本发明还涉及根据式（I）所述的用于治疗认知功能缺陷的化合物，特别是用于改善工作记忆和/或短期记忆的化合物。此外，本发明还涉及根据式（I）制备化合物的工艺。
• WAFER WASHING METHOD, AND LIQUID CHEMICAL USED IN SAME
  申请人：Central Glass Company, Limited

  公开号：EP3340283A1

  公开（公告）日：2018-06-27

  [Object] To provide a water-repellent protective film-forming liquid chemical used in a process of cleaning a wafer by means of a cleaning machine whose liquid contact member contains a vinyl chloride resin. [Solution] A liquid chemical is used, which includes: an alkoxysilane represented by the following general formula [1]; at least one kind selected from the group consisting of a sulfonic acid represented by the following general formula [2], an anhydride of the sulfonic acid, a salt of the sulfonic acid and a sulfonic acid derivative represented by the following general formula [3]; and a diluent solvent containing at least one kind selected from the group consisting of a hydrocarbon, an ether and a thiol.         (R1)aSi(H)b(OR2)4-a-b     [1]         R3-S(=O)2OH     [2]         R3-S(=O)2O-Si(H)3-c(R4)c     [3]

  [目的]提供一种憎水保护膜形成液体化学品，用于通过液体接触部件含有氯乙烯树脂的清洗机清洗晶片的过程。 [解决方案] 使用一种液体化学品，其中包括：由以下通式[1]表示的烷氧基硅烷；至少一种从以下通式[2]表示的磺酸、磺酸的酸酐、磺酸的盐和以下通式[3]表示的磺酸衍生物组成的组中选出的物质；以及至少一种从碳氢化合物、醚和硫醇组成的组中选出的稀释溶剂。 (R1)aSi(H)b(OR2)4-a-b[1]。 R3-S(=O)2OH [2] R3-S(=O)2O-Si(H)3-c(R4)c [3]