tert-butyl N-[2-[2-[2-[3,5-bis(bromomethyl)phenoxy]ethoxy]ethoxy]ethyl]carbamate | 819067-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[2-[2-[2-[3,5-bis(bromomethyl)phenoxy]ethoxy]ethoxy]ethyl]carbamate
• CAS: 819067-01-1
• 化学式: C₁₉H₂₉Br₂NO₅
• 分子量: 511.251
• InChiKey: VBUFQBNZBKWSAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-[2-[2-[3,5-bis(bromomethyl)phenoxy]ethoxy]ethoxy]ethyl]carbamate 在 potassium carbonate 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 38.0h， 生成
  参考文献：
  名称：

  Fluorophore-linked zinc(II)dipicolylamine coordination complexes as sensors for phosphatidylserine-containing membranes

  摘要：

  A series of Zn2+-2,2'-dipicolylamine (Zn2+-DPA) coordination complexes with an attached NBD fluorophore are synthesized and evaluated as fluorescent sensors. The sensors do not respond to vesicles composed of zwitterionic phosphatidylcholine, but the NBD fluorescence emission is enhanced in the presence of anionic vesicles. A sensor with two Zn2+-DPA units and a hydrophilic tris(ethyleneoxy) linker produced a larger emission enhancement than an analogue with a butyl linker, and titration with 1:1 POPC:POPS vesicles lead to an apparent phospholipid association constant of 5.3 x 104 M-1. The sensor can detect the presence of vesicles containing as little as 5% phosphatidylserine. The sensing effect apparently requires a membrane surface because the sensors do not respond to a phosphatidylserine derivative that is monodispersed in aqueous solution. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.052
• 作为产物：
  描述：

  5-羟基间苯二甲酸二乙酯 在 lithium aluminium tetrahydride 、 四溴化碳 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 24.0h， 生成 tert-butyl N-[2-[2-[2-[3,5-bis(bromomethyl)phenoxy]ethoxy]ethoxy]ethyl]carbamate
  参考文献：
  名称：

  Fluorophore-linked zinc(II)dipicolylamine coordination complexes as sensors for phosphatidylserine-containing membranes

  摘要：

  A series of Zn2+-2,2'-dipicolylamine (Zn2+-DPA) coordination complexes with an attached NBD fluorophore are synthesized and evaluated as fluorescent sensors. The sensors do not respond to vesicles composed of zwitterionic phosphatidylcholine, but the NBD fluorescence emission is enhanced in the presence of anionic vesicles. A sensor with two Zn2+-DPA units and a hydrophilic tris(ethyleneoxy) linker produced a larger emission enhancement than an analogue with a butyl linker, and titration with 1:1 POPC:POPS vesicles lead to an apparent phospholipid association constant of 5.3 x 104 M-1. The sensor can detect the presence of vesicles containing as little as 5% phosphatidylserine. The sensing effect apparently requires a membrane surface because the sensors do not respond to a phosphatidylserine derivative that is monodispersed in aqueous solution. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.052

文献信息

• Cyclic polyamines for binding phosphatidylserine
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2149567A1

  公开（公告）日：2010-02-03

  The invention pertains to a compound for binding and detecting phosphatidylserine. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.

  该发明涉及一种用于结合和检测磷脂酰丝氨酸的化合物。根据该发明，该化合物包含一个用于结合二价或三价金属离子的环状多胺单元。该发明的化合物可以含有类似荧光素或放射性同位素的报告标记，包括取代基。
• CYLIC POLYAMINES FOR BINDING PHOSPHATIDYLSERINE
  申请人：Zitzmann-Kolbe Sabine

  公开号：US20110177002A1

  公开（公告）日：2011-07-21

  The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.