2',3',4,4',5,6,7,7'-octa-O-benzylvalidoxylamine A | 124330-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2',3',4,4',5,6,7,7'-octa-O-benzylvalidoxylamine A
• 英文别名: (1S,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)-N-((1S,2S,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-((benzyloxy)methyl)cyclohexyl)cyclohex-2-enamine；(1S,4R,5S,6S)-4,5,6-tris(phenylmethoxy)-3-(phenylmethoxymethyl)-N-[(1S,2S,3S,4R,5R)-2,3,4-tris(phenylmethoxy)-5-(phenylmethoxymethyl)cyclohexyl]cyclohex-2-en-1-amine
• CAS: 124330-54-7
• 化学式: C₇₀H₇₃NO₈
• 分子量: 1056.35
• InChiKey: GZLXKUJUPNBYBW-BLSWFTMFSA-N

物化性质

• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  11
• 重原子数：
  79
• 可旋转键数：
  28
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  85.9
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2',3',4,4',5,6,7,7'-octa-O-benzylvalidoxylamine A 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 水 、 乙腈 为溶剂， 反应 4.5h， 生成 N-((1S,2S,3S,4R,5R)-2,3,4-Tris-benzyloxy-5-benzyloxymethyl-cyclohexyl)-acetamide
  参考文献：
  名称：

  Ogawa, Seiichiro; Nakajima, Akihiro; Miyamoto, Yasunobu, Journal of the Chemical Society. Perkin transactions I, 1991, # 12, p. 3287 - 3290

  摘要：

  DOI：
• 作为产物：
  描述：

  井冈霉素 在 硫酸 、 sodium hydride 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2',3',4,4',5,6,7,7'-octa-O-benzylvalidoxylamine A
  参考文献：
  名称：

  Pseudoglycosyltransferase Catalyzes Nonglycosidic C–N Coupling in Validamycin A Biosynthesis

  摘要：

  Glycosyltransferases are ubiquitous in nature. They catalyze a glycosidic bond formation between sugar donors and sugar or nonsugar acceptors to produce oligo/polysaccharides, glycoproteins, glycolipids, glycosylated natural products, and other sugar-containing entities. However, a trehalose 6-phosphate synthase-like protein has been found to catalyze an unprecedented nonglycosidic C-N bond formation in the biosynthesis of the aminocyclitol antibiotic validamycin A. This dedicated 'pseudoglycosyltransferase' catalyzes a condensation between GDP-valienol and validamine 7-phosphate to give validoxylamine A 7'-phosphate with net retention of the 'anomeric' configuration of the donor cyclitol in the product. The enzyme operates in sequence with a phosphatase, which dephosphorylates validoxylamine A 7'-phosphate to validoxylamine A.

  DOI：

  10.1021/ja203574u

文献信息

• Electrochemical Evaluation of Interaction between Avidin and Biotin Self-assembled Using Marker Ions
  作者：Hideki Kuramitz、Kazuharu Sugawara、Hiroshi Nakamura、Shunitz Tanaka

  DOI：10.1246/cl.1999.725

  日期：1999.8

  The interaction between avidin and biotin as self-assembled monolayer on a gold electrode surface was electrochemically evaluated by monitoring the changes in the electrode response of the ferrocyanide ion as redox-marker. It was clarified that the permeability changes of avidin membrane introduced onto the biotin self-assembled monolayer against ferrocyanide ion were ascribed to electrostatic interaction between avidin and marker ion.

  亲和素与生物素在金电极表面形成自组装单分子层的相互作用通过监测铁氰化物离子的电极响应变化进行了电化学评估。研究表明，引入到生物素自组装单分子层上的亲和素膜对铁氰化物离子的渗透性变化是由于亲和素与标记离子之间的静电相互作用所致。
• OGAWA, SEIICHIRO;MIYAMOTO, YASUNOBU;NAKAJIMA, AKIHIRO, CHEM. LETT.,(1989) N, C. 725-728
  作者：OGAWA, SEIICHIRO、MIYAMOTO, YASUNOBU、NAKAJIMA, AKIHIRO

  DOI：——

  日期：——