9-((4aR,8S,8aS)-2-Phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-9H-purin-6-ylamine | 205382-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: 9-((4aR,8S,8aS)-2-Phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-9H-purin-6-ylamine
• CAS: 205382-61-2
• 化学式: C₁₈H₁₉N₅O₃
• 分子量: 353.381
• InChiKey: RROHVRJVJKLJQH-OKZNRKQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.85
• 重原子数：
  26.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  97.31
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  9-((4aR,8S,8aS)-2-Phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-9H-purin-6-ylamine 在 三氟乙酸 作用下， 以84%的产率得到(2R,3S,4S)-4-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxan-3-ol
  参考文献：
  名称：

  Synthesis of 1,5-Anhydro-D-Mannitol Nucleosides with a Purine Base Moeety

  摘要：

  D-Mannitol nucleosides with a purine base moiety have been conveniently synthesized strating from 1,5-anhydro-4,6-O-benzylidene-D-glucitol. The 3-OH function of 1,5-anhydro-4,6-O-benzylidene-D-glucitol was selectively protected with t-butyldimethylsilyl group and subsequently converted to the corresponding O-triflate derivative for the introduction of the nucleobase moietes. These nucleoside derivatives were transformed to 1,5-Anhydro-6-O-MMTr-2-(N(6)-benzoyladenin-9-yl)-2-deoxy-3-O-TBPMS-D-mannitol and 1,5-Anhydro-6-O-MMTr-2-(N(2)-isobutyrylguanin-9-yl)-2-deoxy-3-O-TBDMS-D-mannitol, useful as the building blocks for oligonucleotide synthesis. Also, the synthesis of the corresponding fully deprotected anhydrohexitol nucleosides were achieved for evaluation of antiviral activity test.

  DOI：

  10.1080/07328319808004713
• 作为产物：
  描述：

  Dithiocarbonic acid O-[(4aR,7S,8S,8aS)-8-(6-amino-purin-9-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl] ester S-methyl ester 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 甲苯 为溶剂， 以45%的产率得到9-((4aR,8S,8aS)-2-Phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-9H-purin-6-ylamine
  参考文献：
  名称：

  Synthesis of 1,5-Anhydro-D-Mannitol Nucleosides with a Purine Base Moeety

  摘要：

  D-Mannitol nucleosides with a purine base moiety have been conveniently synthesized strating from 1,5-anhydro-4,6-O-benzylidene-D-glucitol. The 3-OH function of 1,5-anhydro-4,6-O-benzylidene-D-glucitol was selectively protected with t-butyldimethylsilyl group and subsequently converted to the corresponding O-triflate derivative for the introduction of the nucleobase moietes. These nucleoside derivatives were transformed to 1,5-Anhydro-6-O-MMTr-2-(N(6)-benzoyladenin-9-yl)-2-deoxy-3-O-TBPMS-D-mannitol and 1,5-Anhydro-6-O-MMTr-2-(N(2)-isobutyrylguanin-9-yl)-2-deoxy-3-O-TBDMS-D-mannitol, useful as the building blocks for oligonucleotide synthesis. Also, the synthesis of the corresponding fully deprotected anhydrohexitol nucleosides were achieved for evaluation of antiviral activity test.

  DOI：

  10.1080/07328319808004713

文献信息

• Oligonucleotides Composed of 2‘-Deoxy-1‘,5‘-anhydro-<scp>d</scp>-mannitol Nucleosides with a Purine Base Moiety
  作者：Nafizal Hossain、Berthold Wroblowski、Arthur Van Aerschot、Jef Rozenski、Andre De Bruyn、Piet Herdewijn

  DOI：10.1021/jo9718511

  日期：1998.3.1

  2'-Deoxy-D-mannitol nucleosides with a purine base moiety have been conveniently synthesized starting from 1,5-anhydro-4,6-O-benzylidene-D-glucito The 3-OH function of 1,5-anhydro-4,6-O-benzylidene-D-glucitol was selectively protected with tert-butyldimethylsilyl group, and the 2'-OH function was subsequently converted to the corresponding O-triflate derivative for the introduction of the nucleobase moieties. These nucleoside derivatives were transformed to 1,5-anhydro-4-O-(P-(2 -cyanoethyl)-P-(N,N-diisopropylamino)phosphinyl)-2-deoxy-6-O-monomethoxytrityl-3-O-(tert-butyldimethylsilyl)-D-mannitol with either a 2-(N(6)-benzoyladenin-9-yl) or a 2-(N(2)-isobutyrylguanin-9-yl) substituent as the building blocks for oligonucleotide synthesis. The corresponding fully modified oligonucleotides afford considerably less stable duplexes with RNA as compared to the 3-deoxy hexitol nucleic acid analogues described previously, The reason for the lower stability was investigated using molecular modeling, MD simulations of single strand MNA(GCGTAGCG) and MNA(GCGTAGCG) complexed with RNA(CGCAUCGC) in aqueous solution were performed by use of AMBER 4.1 with the particle mesh Ewald (PME) method for the treatment of long-range electrostatic interactions, Frequent hydrogen bonds between the 3'-hydroxyl and the 6'-O of the phosphate backbone of the following base changed the conformation of the single strand as well as the MNA:RNA complex. The MNA:RNA backbone widens up and shows partial unwinding and disruption of base pair hydrogen bonds consistent with their low hybridization potential.