双(3-氨丙基)苯基膦 | 6775-01-5

• 物质功能分类: 化学试剂 - 有机试剂 - 膦配体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双(3-氨丙基)苯基膦
• 中文别名: 双(3-氨丙基)苯磷
• 英文名称: bis(3-aminopropyl)phenylphosphine
• 英文别名: bis-(3-amino-propyl)-phenyl-phosphine；Bis-(3-amino-propyl)-phenyl-phosphin；Bis-<3-amino-propyl>-phenyl-phosphin；Bis-(3-aminopropyl)-phenyl-phosphin；3-[3-aminopropyl(phenyl)phosphanyl]propan-1-amine
• CAS: 6775-01-5
• 化学式: C₁₂H₂₁N₂P
• mdl: MFCD00014834
• 分子量: 224.286
• InChiKey: OEHBMEXOPYWPKQ-UHFFFAOYSA-N

物化性质

• 沸点：
  144°C/1mm
• 密度：
  1.03
• 闪点：
  144°C/1mm

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  8
• 危险品运输编号：
  UN3267
• 海关编码：
  2921499090
• 包装等级：
  III

反应信息

• 作为反应物：
  描述：

  tris(triphenylphosphine)ruthenium(II) chloride 、 双(3-氨丙基)苯基膦 以 甲苯 为溶剂， 反应 2.0h， 以86%的产率得到[Ru(bis(3-aminopropyl)phenylphosphine)PPh₃(Cl)₂]
  参考文献：
  名称：

  使用带有市售和易于获得的氮和磷供体配体的钌催化剂对苯乙酮进行快速转移加氢

  摘要：

  描述了Ru络合物的筛选，合成和测试，这些络合物是由可商购的配体或可以一步合成的配体生成的。测试了催化剂在异丙苯转移氢化中苯乙酮的活性，异丙醇是氧化物种之间氢转移过程的探针反应，通常在生物质升级以及精细和特殊化学合成等应用中发现。通过原位催化剂生成进行配体筛选，并检查带有N H或C N官能团的NPN和NNN钳型配体。发现最活跃的转移氢化催化剂是那些带有N的催化剂H官能团，作为氨基或作为苯并咪唑基。随后合成了明确的催化剂前体，包括新颖的络合物[Ru（1）PPh 3（Cl）2 ]（其中（1）=双（3-氨基丙基）苯基膦），这是该NPN配体的第一个报道的Ru络合物。还对已建立的（PN）2和PP / NN酮氢化催化剂进行了转移氢容量的筛选，其中[Ru（Ph PN）2 Cl 2 ]（Ph PN = 2-（diphenylphosphino）ethylamine）最具活性。随后，[Ru（1）PPh 3（Cl）2

  DOI：

  10.1016/j.apcata.2018.11.031
• 作为产物：
  描述：

  双(2-氰基乙基)苯基膦 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 48.0h， 以75%的产率得到双(3-氨丙基)苯基膦
  参考文献：
  名称：

  水性Heck反应中含阳离子胍官能团的膦配体的合成与研究。

  摘要：

  首次制备了具有强碱性和亲水性胍鎓官能团的膦2和3。这些配体与乙酸钯组合形成促进水性Heck反应的活性催化剂。

  DOI：

  10.1016/0040-4020(94)01101-5

文献信息

• Coordination chemistry of bis(3-aminopropyl)phenylphosphine (bap): reactions of bap with some d6 metal complexes of molybdenum(0), tungsten(0) and platinum(IV)
  作者：Michael A. Beckett、Devin P. Cassidy、Adam J. Duffin

  DOI：10.1016/s0020-1693(00)80193-0

  日期：1991.11

  been reacted with fac -[PtMe 3 I} 4 ] in CHCl 3 solution to yield fac -[PtMe 3 (bap)]I which has the bap ligand tridentate NNP. Metathesis of fac -[PtMe 3 (bap)]I with Na[BPh 4 ] in thf solution results in fac -[PtMe 3 (bap)][BPh 4 ]. Bap is also NNP tridentate in the Group 6 metal(0) complexes fac -[Mo(CO) 3 (bap)] and fac -[W(CO) 3 (bap)], prepared from the reactions of bap with cis -[M(CO) 4 (pip)

  摘要使双（3-氨基丙基）苯基膦（bap）与fac-[PtMe 3 I} 4]在CHCl 3溶液中反应，生成具有bap配体三齿NNP的fac-[PtMe 3（bap）] I。溶液中的Na [BPh 4]与fac-[PtMe 3（bap）] I复分解生成fac-[PtMe 3（bap）] [BPh 4]。在第6组金属（0）配合物fac-[Mo（CO）3（bap）]和fac-[W（CO）3（bap）]中，bap也是NNP三齿的，由bap与顺式-[[ M（CO）4（pip）2]（M ＝ Mo，W）。新的配合物已通过熔点，元素分析，红外和多元素（1 H，11 B，31 P）NMR光谱进行了表征。
• Mangenese(II) and manganese(III) complexes of linear pentadentate Schiff base ligands
  作者：W.M. Coleman

  DOI：10.1016/s0020-1693(00)90484-5

  日期：1981.1

  Abstract Mangenese(II) and manganese(III) complexes of linear potentially pentadentate ligands with donor sets of O 2 N 2 P and N 4 P derived from substituted salicylaldehydes and pyridine with a polyamine have been synthesized. Characterization via elemental analysis, infrared-visible spectra and magnetic susceptibility has been accomplished. Pentacoordinate high spin complexes are produced in all

  摘要合成了线性潜在的五齿配体与由多胺取代的水杨醛和吡啶衍生的O 2 N 2 P和N 4 P供体组的Mangenese（II）和锰（III）配合物。通过元素分析，红外可见光谱和磁化率进行了表征。在所有情况下均产生五配位高自旋复合物。讨论了与二氧化氮和一氧化氮的各种氧化态的反应性。
• NOVEL MUCOLYTIC AGENTS
  申请人：JOHNSON Michael R.

  公开号：US20150307530A1

  公开（公告）日：2015-10-29

  Provided is a method of liquefying mucus from mucosal surfaces by administering compounds containing a phosphine group.

  提供了一种通过给予含有膦基团化合物的方法，使粘液从黏膜表面液化的方法。
• Process for the oligomerization of ethylene
  申请人：GULF RESEARCH & DEVELOPMENT COMPANY

  公开号：EP0046329A1

  公开（公告）日：1982-02-24

  Ethylene is oligomerized by contacting ethylene under oligomerization conditions with a nickel ylide defined by the following Formula I: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are either alike or different members selected from the group consisting of hydrogen, alkyl radicals having from about one to about 24 carbon atoms, preferably from about one to about 10 carbon atoms; aryl radicals having from about six to about 20 carbon atoms, preferably from about six to about 10 carbon atoms; alkenyl radicals having from about two to about 30 carbons atoms, preferably from about two to about 20 carbon atoms; cycloalkyl radicals having from about three to about 40 carbon atoms, preferably from about three to about 30 carbon atoms; aralkyl and alkaryl radicals having from about six to about 40 carbon atoms, preferably from about six to about 30 carbon atoms; a halogen radical selected from the group consisting of fluorine, chlorine, bromine and iodine, preferably chlorine; a hydroxyl group; an alkoxy or aryloxy group; and a hydrocarbyl group, such as defined above, carrying halogen, hydroxyl or alkoxy or aryloxy; provided that at least one, preferably from about one to about four, of each of R1, to R8 is a sulfonato group (-SO3-) or an alkyl, aryl, alkenyl, cycloalkyl, aralkyl or alkaryl group carrying a sulfonato group; M is sulfur or oxygen, preferably oxygen; E is phosphorus, arsenic, antimony or nitrogen, preferably phosphorus; and F is phosphorus, arsenic or antimony, preferably phosphorus. This process is characterized by a relatively high reaction rate at low temperatures and pressures and results in the production of relatively high proportions of desirable trimer, tetramer, pentamer, and higher olefinic products.

  在低聚条件下，将乙烯与下式 I 所定义的镍酰亚胺接触，可使乙烯低聚： 其中 R1、R2、R3、R4、R5、R6、R7 和 R8 要么是相同的成员，要么是不同的成员，它们选自由氢、具有约 1 至约 24 个碳原子（最好是约 1 至约 10 个碳原子）的烷基、具有约 6 至约 20 个碳原子（最好是约 6 至约 10 个碳原子）的芳基组成的组；具有约 2 至约 30 个碳原子，最好是约 2 至约 20 个碳原子的烯基； 具有约 3 至约 40 个碳原子，最好是约 3 至约 30 个碳原子的环烷基； 具有约 6 至约 40 个碳原子，最好是约 6 至约 30 个碳原子的芳基和烷芳基；从氟、氯、溴和碘（最好是氯）组成的组中选出的卤素基；羟基；烷氧基或芳氧基；以及烃基，如上文所定义的，带有卤素、羟基或烷氧基或芳氧基的烃基；R1至R8中至少有一个，最好是约一个至约四个，是磺酸基（-SO3-）或带有磺酸基的烷基、芳基、烯基、环烷基、芳基或烷芳基；M是硫或氧，最好是氧；E是磷、砷、锑或氮，最好是磷；F是磷、砷或锑，最好是磷。该工艺的特点是在低温低压下反应速度相对较快，可生产出比例相对较高的理想三聚体、四聚体、五聚体和更高的烯烃产品。
• Nickel ylides
  申请人：GULF RESEARCH & DEVELOPMENT COMPANY

  公开号：EP0046331A2

  公开（公告）日：1982-02-24

  A new group of nickel ylides is provided that is highly active at relatively low operating temperatures and pressures in the oligomerization of ethylene. The compounds can be defined by the following Formula I: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are either alike or different members selected from the group consisting of hydrogen, alkyl radicals having from about one to about 24 carbon atoms, preferably from about one to about 10 carbon atoms; aryl radicals having from about six to about 20 carbon atoms, preferably from about six to about 10 carbon atoms; alkenyl radicals having from about two to about 30 carbons atoms, preferably from about two to about 20 carbon atoms; cycloalkyl radicals having from about three to about 40 carbon atoms, preferably from about three to about 30 carbon atoms; aralkyl and alkaryl radicals having from about six to about 40 carbon atoms, preferably from about six to about 30 carbon atoms; a halogen radical selected from the group consisting of fluorine, chlorine, bromine and iodine, preferably chlorine; a hydroxyl group; an alkoxy or aryloxy group; and a hydrocarbyl group, such as defined above, carrying halogen, hydroxyl or alkoxy or aryloxy; provided that at least one, preferably from about one to about four, of each of R1 to R8 is a sulfonato group (-SO3-) or an alkyl, aryl, alkenyl, cycloalkyl, aralkyl or alkaryl group carrying a sulfonato group; M is sulfur or oxygen, preferably oxygen; E is phosphorus, arsenic, antimony or nitrogen, preferably phosphorus; and F is phosphorus, arsenic or antimony, preferably phosphorus.

  本研究提供了一组新的镍酰化物，在相对较低的工作温度和压力下，它们在乙烯的低聚过程中具有很高的活性。这些化合物可以用下式 I 来定义： 其中 R1、R2、R3、R4、R5、R6、R7 和 R8 要么是相同的成员，要么是不同的成员，它们选自氢、具有约 1 至约 24 个碳原子的烷基，最好是具有约 1 至约 10 个碳原子的烷基；具有约 6 至约 20 个碳原子的芳基，最好是具有约 6 至约 10 个碳原子的芳基；具有约 2 至约 30 个碳原子，最好是约 2 至约 20 个碳原子的烯基； 具有约 3 至约 40 个碳原子，最好是约 3 至约 30 个碳原子的环烷基； 具有约 6 至约 40 个碳原子，最好是约 6 至约 30 个碳原子的芳基和烷芳基；从氟、氯、溴和碘（最好是氯）组成的组中选出的卤素基；羟基；烷氧基或芳氧基；以及烃基，如上文所定义的，带有卤素、羟基或烷氧基或芳氧基的烃基；条件是 R1 至 R8 中至少有一个（最好是约一个至约四个）是磺酸基（-SO3-）或带有磺酸基的 烷基、芳基、烯基、环烷基、芳基或烷芳基；M 是硫或氧，最好是氧；E 是磷、砷、锑或氮，最好是磷；F 是磷、砷或锑，最好是磷。

表征谱图