1-chloro-3-(2-nitrophenoxy)propan-2-ol | 55883-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-chloro-3-(2-nitrophenoxy)propan-2-ol
• 英文别名: 1-chloro-3-(2-nitro-phenoxy)-propan-2-ol；1-Chlor-3-(2-nitro-phenoxy)-propan-2-ol
• CAS: 55883-22-2
• 化学式: C₉H₁₀ClNO₄
• 分子量: 231.636
• InChiKey: JLWYUYUMWOZWBL-UHFFFAOYSA-N

物化性质

• 沸点：
  160 °C(Press: 0.5 Torr)
• 密度：
  1.382±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-chloro-3-(2-nitrophenoxy)propan-2-ol 在 三氟乙酸酐 作用下， 以 二氯甲烷 为溶剂， 生成 3-(4-morpholinyl)-1-(2-nitrophenoxy)-2-propanone
  参考文献：
  名称：

  Tamagnan; Lu; Gao, Journal of labelled compounds and radiopharmaceuticals, 1999, vol. 42, # SUPPL. 1, p. S191-S193

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-环氧-3-(2-硝基苯氧基)丙烷 在 lithium chloride 、 copper dichloride 作用下， 以 四氢呋喃 为溶剂， 以94%的产率得到1-chloro-3-(2-nitrophenoxy)propan-2-ol
  参考文献：
  名称：

  Maciejewski; Poltorak; Kaminska, Polish Journal of Chemistry, 2009, vol. 83, # 4, p. 595 - 604

  摘要：

  DOI：

文献信息

• Antihypertensive indole derivatives of phenoxypropanolamines with .beta.-adrenergic receptor antagonist and vasodilating activity
  作者：William E. Kreighbaum、W. Lesley Matier、Ronald D. Dennis、Joseph L. Minielli、David Deitchman、James L. Perhach、William T. Comer

  DOI：10.1021/jm00177a015

  日期：1980.3

  A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl [i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), beta-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with beta adrenergic receptor antagonist and vasodilating action. The structure--activity relationships in these tests are discussed.
• .beta.-Adrenergic blocking agents. V. 1-Amino-3-(substituted phenoxy)-2-propanols
  作者：Albert F. Crowther、D. J. Gilman、B. J. McLoughlin、Leslie Harold Smith、R. W. Turner、T. M. Wood

  DOI：10.1021/jm00304a018

  日期：1969.7
• The condensation of epichlorohydrin with monohydric phenols and with catechol
  作者：O. Stephenson

  DOI：10.1039/jr9540001571

  日期：——
• Lipase resolution of new (±)-3-aryloxy-1-halogenopropan-2-ols: Versatile building blocks for β-adrenergic receptor antagonists
  作者：Maciej Maciejewski、Krzysztof Półtorak、Janina E. Kamińska

  DOI：10.1016/j.molcatb.2009.11.004

  日期：2010.3

  Using two commercial immobilized lipases Lipozyme(R) TL and Novozym(R) 435 effective kinetic resolution of several novel 3-aryloxy-1-halogenopropan-2-ols was achieved by acyl transfer reaction in organic solvents, yielding both enantiomers with 89-99% ee. In preparative resolutions carried out in tert-butyl methyl ether at 25 degrees C with vinyl acetate as acyl donor enantioselectivity ratio E was from 64 to 99. The resolved enantiomers were successfully used as chiral building blocks in the synthesis of new 1-alkylamino-3-aryloxypropan-2-ols, by nucleophilic halogen substitution with isopropylamine and tert-butylamine. The obtained products will be evaluated in vitro as potential new beta-adrenergic receptors antagonists. (C) 2009 Elsevier B.V. All rights reserved.
• Maciejewski; Poltorak; Kaminska, Polish Journal of Chemistry, 2009, vol. 83, # 4, p. 595 - 604
  作者：Maciejewski、Poltorak、Kaminska

  DOI：——

  日期：——