3-甲基-4-丙烯基-苯甲醚 | 53773-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 3-甲基-4-丙烯基-苯甲醚
• 英文名称: 3-methyl-4-propenyl-anisole
• 英文别名: 3-Methyl-4-propenyl-anisol；4-Methoxy-2-methyl-1-prop-1-enylbenzene；4-methoxy-2-methyl-1-prop-1-enylbenzene
• CAS: 53773-74-3
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: WKYNTJYJZSIBGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-甲基-4-丙烯基-苯甲醚 在 氢溴酸 、 氢碘酸 、 溶剂黄146 、 甲苯 作用下， 生成 3,4-bis-(4-hydroxy-2-methyl-phenyl)-hexane
  参考文献：
  名称：

  SYNTHESIS OF NEW HOMOLOGS OF HEXESTROL

  摘要：

  DOI：

  10.1021/jo01158a025
• 作为产物：
  描述：

  间甲基苯甲醚 在 三氯化铝 、 乙醇 、 sodium 、 Petroleum ether 作用下， 生成 3-甲基-4-丙烯基-苯甲醚
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x

文献信息

• Benign catalysis with iron: facile assembly of cyclobutanes and cyclohexenes <i>via</i> intermolecular radical cation cycloadditions
  作者：Yushuang Yu、Yu Fu、Fangrui Zhong

  DOI：10.1039/c8gc00299a

  日期：——

  We describe novel and facile iron-catalyzed crossed intermolecular radical cation cycloadditions of styrenes. This catalysis features high efficiency, atom economy, stereospecificity, scalability and very mild reaction conditions. Thus, these reactions represent a benign and sustainable strategy for the synthesis of valuable functionalized cyclobutanes and cyclohexenes.

  我们描述了苯乙烯的新型和易铁催化的交叉分子间自由基阳离子环加成反应。这种催化具有高效，原子经济，立体特异性，可扩展性和非常温和的反应条件的特点。因此，这些反应代表了合成有价值的官能化环丁烷和环己烯的良性且可持续的策略。