N-(2-N',N'-dimethylaminoethyl)-β-alanine tert-butyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-N',N'-dimethylaminoethyl)-β-alanine tert-butyl ester
• 英文别名: tert-Butyl 3-{[2-(dimethylamino)ethyl]amino}propanoate；tert-butyl 3-[2-(dimethylamino)ethylamino]propanoate
• 化学式: C₁₁H₂₄N₂O₂
• 分子量: 216.324
• InChiKey: QNISDLUYBBZBGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-N',N'-dimethylaminoethyl)-β-alanine tert-butyl ester 、 N,N'-(丁二酰二氧基)二琥珀酰亚胺 以 乙腈 为溶剂， 反应 2.0h， 生成 (2,5-Dioxopyrrolidin-1-yl) 4-[2-(dimethylamino)ethyl-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]amino]-4-oxobutanoate
  参考文献：
  名称：

  [EN] ANTIFIBRINOLYTIC COMPOUNDS
  [FR] COMPOSÉS ANTIFIBRINOLYTIQUES

  摘要：

  公开号：

  WO2016073493A3
• 作为产物：
  描述：

  3-氨基丙酸叔丁酯 、 2-溴-N,N-二甲基乙胺氢溴酸盐 在 sodium carbonate 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 N-(2-N',N'-dimethylaminoethyl)-β-alanine tert-butyl ester
  参考文献：
  名称：

  [EN] ANTIFIBRINOLYTIC COMPOUNDS
  [FR] COMPOSÉS ANTIFIBRINOLYTIQUES

  摘要：

  公开号：

  WO2016073493A3

文献信息

• NOVEL SPIROINDOLINE COMPOUND, AND MEDICINAL AGENT COMPRISING SAME
  申请人：KOWA COMPANY, LTD.

  公开号：US20140309207A1

  公开（公告）日：2014-10-16

  The present invention provides a novel compound represented by a general formula (1) as shown below, which has a glucokinase-activating action in the liver and pancreatic β-cells and which is useful as an agent for preventing and/or treating diseases caused by hyperglycemia, such as diabetes. A spiroindoline compound represented by the general formula (1), or a salt thereof, or a solvate of the compound or the salt: [wherein ring A represents a nitrogen-containing 5-10 membered heteroaryl group; R 1 and R 2 , which are the same or different, each represent a hydrogen atom, a halogen atom, a halo C 1-6 alkyl group, a C 6-10 aryl group, a cyano group, a C 1-6 alkyl group optionally having a substituent, a C 2-6 alkenyl group optionally having a substituent, etc.; R 3 represents a hydrogen atom, a C 1-6 alkyl group optionally having a substituent, etc.; and R 4 represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group optionally having a substituent, etc.]

  本发明提供了一种新型化合物，其通式（1）如下所示，具有在肝脏和胰岛β细胞中激活葡萄糖激酶的作用，并可用作预防和/或治疗由高血糖引起的疾病，如糖尿病的药物。该通式（1）表示的螺环吲哚化合物，或其盐，或化合物或盐的溶剂：[其中环A代表含氮的5-10成员杂环基；R1和R2，相同或不同，分别代表氢原子，卤原子，卤代C1-6烷基，C6-10芳基，氰基，C1-6烷基，可选取代基，C2-6烯基，可选取代基等；R3代表氢原子，C1-6烷基，可选取代基等；R4代表氢原子，卤原子，C1-6烷基，可选取代基等。]
• TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES
  申请人：NUEVOLUTION A/S

  公开号：US20150315567A1

  公开（公告）日：2015-11-05

  The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.

  本发明涉及一种合成模板分子的方法。在本发明的一个方面中，模板分子与模板连接在一起，从而模板化其合成。该方法允许生成图书馆，可用于筛选例如治疗活性。
• Templated molecules and methods for using such molecules
  申请人：Nuevolution A/S

  公开号：EP2305808A1

  公开（公告）日：2011-04-06

  The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.

  本发明涉及一种合成模板分子的方法。在本发明的一个方面，模板化分子与合成模板相连。本发明可生成可进行治疗等活性筛选的文库。
• Antifibrinolytic compounds
  申请人：THROMBOLYTICS, LLC

  公开号：US10202331B2

  公开（公告）日：2019-02-12

  The present invention provides novel and antifibrinolytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding. The present application relates to numerous embodiments of chemical structures which in whole or in part mimic or are analogs of the amino acid Lysine such that they bind to specific binding site(s) within specific protein sub structures in the structures of Plasminogen, and/or Plasmin, and/or Plasminogen Activators, and/or Thrombin.

  本发明提供了新型抗纤维蛋白溶解化合物、其制备工艺、药物和兽药组合物及其在医学中的用途，特别是用于治疗出血。本申请涉及许多化学结构的实施方案，这些化学结构全部或部分模仿氨基酸赖氨酸或其类似物，从而使它们与特定蛋白质子结构中的特定结合位点结合，这些蛋白质子结构包括血浆蛋白酶原、和/或血浆蛋白、和/或血浆蛋白酶原激活剂、和/或凝血酶。
• ANTIFIBRINOLYTIC COMPOUNDS
  申请人：THROMBOLYTICS, LLC

  公开号：US20170334834A1

  公开（公告）日：2017-11-23

  The present invention provides novel antifibrinilytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding.