17-iodo-9-telluraheptadecanoic acid | 81579-38-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 17-iodo-9-telluraheptadecanoic acid
• 英文别名: 17-Iodo-9-tellura-heptadecanoic acid；8-(8-iodooctyltellanyl)octanoic acid
• CAS: 81579-38-6
• 化学式: C₁₆H₃₁IO₂Te
• 分子量: 509.925
• InChiKey: YLCDEDKVFKQCHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.73
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dimethyl 9,10-ditelluraoctadecane-1,18-dioate 在 sodium hydroxide 、 sodium tetrahydroborate 、 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 8.0h， 生成 17-iodo-9-telluraheptadecanoic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of 17-[131I]iodo-9-telluraheptadecanoic acid, a potential myocardial imaging agent

  摘要：

  A method has been developed for the preparation of terminal halogenated tellurium fatty acids (X-R-Te-R'-COOH). The synthesis and physical properties of 17-bromo- and 17-iodo-9-telluraheptadecanoic acid (17-iodo-9-THDA) are described. The radiohalogenated agents are of interest as a result of their expected pronounced and prolonged heart uptake and potential use for evaluation of regional myocardial fatty acid metabolism. Evaluation in rats indicates that the myocardial uptake of 17-[131I]iodo-9-telluraheptadecanoic acid (17-[131I]iodo-9-THDA) is accompanied by significant in vivo deiodination. A comparison of the heart uptake and deiodination of 17-[131I]iodo-9-THDA and 16-[131I]iodopalmitic acid has demonstrated a close similarity in blood levels of radioactivity and thyroid uptake of radioiodide after administration of these agents to rats. These data suggest that the mechanism of deiodination of terminal radioiodinated alkanoic acids primarily results from direct cleavage of the carbon-iodine bond and not from loss of radioiodine from the final catabolite.

  DOI：

  10.1021/jm00348a001

文献信息

• GOODMAN, M. M.;KNAPP, F. F. ,, JR;CALLAHAN, A. P.;FERREN, L. A., J. MED. CHEM., 1982, 25, N 6, 613-618
  作者：GOODMAN, M. M.、KNAPP, F. F. ,, JR、CALLAHAN, A. P.、FERREN, L. A.

  DOI：——

  日期：——