2-[2-ethoxycarbonyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl]-benzoic acid methyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-ethoxycarbonyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl]-benzoic acid methyl ester
• 英文别名: Methyl 2-[3-ethoxy-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxypropyl]benzoate；methyl 2-[3-ethoxy-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxypropyl]benzoate
• 化学式: C₂₂H₃₃NO₅
• 分子量: 391.508
• InChiKey: ZZBHDQZWRSAQLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[2-ethoxycarbonyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl]-benzoic acid methyl ester 在 溶剂黄146 、 锌 作用下， 反应 2.0h， 以68%的产率得到ethyl 1-oxoisochromane-3-carboxylate
  参考文献：
  名称：

  Intermolecular Radical Carboaminohydroxylation of Olefins with Aryl Diazonium Salts and TEMPO

  摘要：

  Highly reactive aryl radicals can selectively be reacted with a broad variety of activated and nonactivated olefinic substrates in the presence of nitroxyl radicals. Direct recombination of the aryl radical and the nitroxide as well as telomerization of the olefin is successfully suppressed by the reaction conditions.

  DOI：

  10.1021/ol701622d
• 作为产物：
  描述：

  2,2,6,6-四甲基哌啶氧化物 、 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 、 丙烯酸乙酯 在 iron(II) sulfate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 0.17h， 以63%的产率得到2-[2-ethoxycarbonyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl]-benzoic acid methyl ester
  参考文献：
  名称：

  Intermolecular Radical Carboaminohydroxylation of Olefins with Aryl Diazonium Salts and TEMPO

  摘要：

  Highly reactive aryl radicals can selectively be reacted with a broad variety of activated and nonactivated olefinic substrates in the presence of nitroxyl radicals. Direct recombination of the aryl radical and the nitroxide as well as telomerization of the olefin is successfully suppressed by the reaction conditions.

  DOI：

  10.1021/ol701622d

文献信息

• Intermolecular Radical Carboaminohydroxylation of Olefins with Aryl Diazonium Salts and TEMPO
  作者：Markus R. Heinrich、Alexander Wetzel、Marcel Kirschstein

  DOI：10.1021/ol701622d

  日期：2007.9.1

  Highly reactive aryl radicals can selectively be reacted with a broad variety of activated and nonactivated olefinic substrates in the presence of nitroxyl radicals. Direct recombination of the aryl radical and the nitroxide as well as telomerization of the olefin is successfully suppressed by the reaction conditions.