((2R)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)acetic acid ethyl ester | 79171-66-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ((2R)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)acetic acid ethyl ester
• 英文别名: N-(N-benzyloxycarbonyl-D-leucyl)glycine ethyl ester；ethyl 2-[[(2R)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]acetate
• CAS: 79171-66-7
• 化学式: C₁₈H₂₆N₂O₅
• 分子量: 350.415
• InChiKey: MPFMGTPIJXYPBS-OAHLLOKOSA-N

物化性质

• 熔点：
  96 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• 沸点：
  526.2±40.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ((2R)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)acetic acid ethyl ester 在 palladium on activated charcoal 氢气 、 sodium cyanoborohydride 、 sodium sulfate 作用下， 以 乙醇 为溶剂， 反应 3.5h， 生成 N-(N-butyl-D-leucyl)glycine ethyl ester
  参考文献：
  名称：

  Circular dichroism studies on absolute configuration assignment of peptidomimetics with a terminal chiral 3-arylpropionic acid unit

  摘要：

  The relationship between the molecular structure of peptidomimetics 1 and their chiroptical properties has been studied using circular dichroism spectroscopy. It was demonstrated that the sign of the Cotton effects occurring around 230 and 270 nm enables the direct assignment of stereochemistry at C-1 and C-3 carbon atoms. The TD-DFT calculations of the circular dichroisin (CD) spectrum of one of the model compounds confirm the absolute stereochemistry assignment made experimentally. Thus, CD spectroscopy proved to be a simple, reliable and general tool for the determination of the absolute configuration of the stereogenic centers of peptidomimetics with a terminal 3-arylpropionic group. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.08.024
• 作为产物：
  描述：

  D-亮氨酸 在 sodium hydroxide 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 ((2R)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)acetic acid ethyl ester
  参考文献：
  名称：

  Circular dichroism studies on absolute configuration assignment of peptidomimetics with a terminal chiral 3-arylpropionic acid unit

  摘要：

  The relationship between the molecular structure of peptidomimetics 1 and their chiroptical properties has been studied using circular dichroism spectroscopy. It was demonstrated that the sign of the Cotton effects occurring around 230 and 270 nm enables the direct assignment of stereochemistry at C-1 and C-3 carbon atoms. The TD-DFT calculations of the circular dichroisin (CD) spectrum of one of the model compounds confirm the absolute stereochemistry assignment made experimentally. Thus, CD spectroscopy proved to be a simple, reliable and general tool for the determination of the absolute configuration of the stereogenic centers of peptidomimetics with a terminal 3-arylpropionic group. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.08.024

文献信息

• CORT, J. H.
  作者：CORT, J. H.

  DOI：——

  日期：——
• Circular dichroism studies on absolute configuration assignment of peptidomimetics with a terminal chiral 3-arylpropionic acid unit
  作者：Jadwiga Frelek、Anna Fryszkowska、Marcin Kwit、Ryszard Ostaszewski

  DOI：10.1016/j.tetasy.2006.08.024

  日期：2006.10

  The relationship between the molecular structure of peptidomimetics 1 and their chiroptical properties has been studied using circular dichroism spectroscopy. It was demonstrated that the sign of the Cotton effects occurring around 230 and 270 nm enables the direct assignment of stereochemistry at C-1 and C-3 carbon atoms. The TD-DFT calculations of the circular dichroisin (CD) spectrum of one of the model compounds confirm the absolute stereochemistry assignment made experimentally. Thus, CD spectroscopy proved to be a simple, reliable and general tool for the determination of the absolute configuration of the stereogenic centers of peptidomimetics with a terminal 3-arylpropionic group. (c) 2006 Elsevier Ltd. All rights reserved.