2-(2,2-Dimethoxyethyl)-1-nitro-4-phenylmethoxybenzene | 250739-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,2-Dimethoxyethyl)-1-nitro-4-phenylmethoxybenzene
• 英文别名: 2-(2,2-dimethoxyethyl)-1-nitro-4-phenylmethoxybenzene
• CAS: 250739-31-2
• 化学式: C₁₇H₁₉NO₅
• 分子量: 317.342
• InChiKey: HSZSJWCVHMIAMB-UHFFFAOYSA-N

物化性质

• 沸点：
  433.3±40.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  73.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2,2-Dimethoxyethyl)-1-nitro-4-phenylmethoxybenzene 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以70%的产率得到4-氨基-3-(2,2-二甲氧基乙基)-苯酚
  参考文献：
  名称：

  A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters

  摘要：

  [GRAPHICS]A new safety catch linker for solid phase organic synthesis is described. Synthesis and attachment of the linker to the solid phase was achieved via a simple and high yielding strategy. The linker was exemplified by acylation to form unactivated amides, activation of the linker, and cleavage to release acyl moieties. Acids, amides, or esters were released under mild conditions and with exceptionally high purity. The reactivities of unactivated and activated amides are compared.

  DOI：

  10.1021/ol990785h
• 作为产物：
  描述：

  4-硝基间甲苯酚 在 camphor-10-sulfonic acid 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 2-(2,2-Dimethoxyethyl)-1-nitro-4-phenylmethoxybenzene
  参考文献：
  名称：

  A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters

  摘要：

  [GRAPHICS]A new safety catch linker for solid phase organic synthesis is described. Synthesis and attachment of the linker to the solid phase was achieved via a simple and high yielding strategy. The linker was exemplified by acylation to form unactivated amides, activation of the linker, and cleavage to release acyl moieties. Acids, amides, or esters were released under mild conditions and with exceptionally high purity. The reactivities of unactivated and activated amides are compared.

  DOI：

  10.1021/ol990785h

文献信息

• A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters
  作者：Matthew H. Todd、Steven F. Oliver、Chris Abell

  DOI：10.1021/ol990785h

  日期：1999.10.1

  [GRAPHICS]A new safety catch linker for solid phase organic synthesis is described. Synthesis and attachment of the linker to the solid phase was achieved via a simple and high yielding strategy. The linker was exemplified by acylation to form unactivated amides, activation of the linker, and cleavage to release acyl moieties. Acids, amides, or esters were released under mild conditions and with exceptionally high purity. The reactivities of unactivated and activated amides are compared.