N,N-Diethyl-4-(2-thiophen-3-yl-ethoxymethyl)-benzenesulfonamide | 212262-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-Diethyl-4-(2-thiophen-3-yl-ethoxymethyl)-benzenesulfonamide
• 英文别名: N,N-Diethyl-4-[[2-(3-thienyl)ethoxy]methyl]benzenesulfonamide；N,N-diethyl-4-(2-thiophen-3-ylethoxymethyl)benzenesulfonamide
• CAS: 212262-19-6
• 化学式: C₁₇H₂₃NO₃S₂
• 分子量: 353.507
• InChiKey: KMQGVZVITMVIMS-UHFFFAOYSA-N

物化性质

• 沸点：
  467.2±55.0 °C(Predicted)
• 密度：
  1.202±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-Diethyl-4-(2-thiophen-3-yl-ethoxymethyl)-benzenesulfonamide 在 芘 、 四丁基氟化铵 、 三乙胺 作用下， 以 乙醚 、 水 、 乙腈 为溶剂， 反应 5.0h， 生成 N-Benzyl-4-(2-thiophen-3-yl-ethoxymethyl)-benzenesulfonamide
  参考文献：
  名称：

  Chemical synthesis at solid interfaces. On the use of conducting polythiophenes equipped of adequate linkers allowing a facile and highly selective cathodic SN bond scission with a fully regenerating resin process

  摘要：

  Electrogenerated polythiophenes were evaluated as;Merrifield-like resins for the anchoring of amine functions together with deprotection processes. Suitable linkers were terminated with a fully regenerable aromatic sulfonamide moiety. The S-N bond was cleaved to liberate the amine with high selectivity under very mild conditions by cathodic means with amine liberation. Moreover a facile recycling process of the resin allows the further grafting of various amine functions. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00580-8
• 作为产物：
  描述：

  4-溴甲基苯磺酰氯 在 potassium tert-butylate 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 7.0h， 生成 N,N-Diethyl-4-(2-thiophen-3-yl-ethoxymethyl)-benzenesulfonamide
  参考文献：
  名称：

  Chemical synthesis at solid interfaces. On the use of conducting polythiophenes equipped of adequate linkers allowing a facile and highly selective cathodic SN bond scission with a fully regenerating resin process

  摘要：

  Electrogenerated polythiophenes were evaluated as;Merrifield-like resins for the anchoring of amine functions together with deprotection processes. Suitable linkers were terminated with a fully regenerable aromatic sulfonamide moiety. The S-N bond was cleaved to liberate the amine with high selectivity under very mild conditions by cathodic means with amine liberation. Moreover a facile recycling process of the resin allows the further grafting of various amine functions. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00580-8

文献信息

• Chemical synthesis at solid interfaces. On the use of conducting polythiophenes equipped of adequate linkers allowing a facile and highly selective cathodic SN bond scission with a fully regenerating resin process
  作者：J.F. Pilard、G. Marchand、J. Simonet

  DOI：10.1016/s0040-4020(98)00580-8

  日期：1998.8

  Electrogenerated polythiophenes were evaluated as;Merrifield-like resins for the anchoring of amine functions together with deprotection processes. Suitable linkers were terminated with a fully regenerable aromatic sulfonamide moiety. The S-N bond was cleaved to liberate the amine with high selectivity under very mild conditions by cathodic means with amine liberation. Moreover a facile recycling process of the resin allows the further grafting of various amine functions. (C) 1998 Elsevier Science Ltd. All rights reserved.