3-hydroxy-3-isobutyl-5-methyl-hexanoic acid | 179174-14-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxy-3-isobutyl-5-methyl-hexanoic acid
• 英文别名: 3-Hydroxy-3-isobutyl-5-methyl-hexansaeure；β.β-Diisobutyl-hydracrylsaeure；β-Oxy-γ.γ'-di-isopropyl-isovaleriansaeure；β-Oxy-β.β-diisobutylpropionsaeure；3-hydroxy-3-(2-methylpropyl)-5-methylhexanoic acid；2-Oxy-4-methyl-2-isobutyl-pentan-carbonsaeure-(1)；3-Hydroxy-5-methyl-3-(2-methylpropyl)hexanoic acid
• CAS: 179174-14-2
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: LKTWAQYRNLLYQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-3-isobutyl-5-methyl-hexanoic acid 在 硫酸 作用下， 生成 3-isobutyl-5-methyl-hex-2-enoic acid 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Kon; May, Journal of the Chemical Society, 1927, p. 1554

  摘要：

  DOI：
• 作为产物：
  描述：

  二异丁基酮 生成 3-hydroxy-3-isobutyl-5-methyl-hexanoic acid
  参考文献：
  名称：

  Piperidine derivatives with PAF antagonist activity

  摘要：

  通式I及其盐和溶剂合物是PAF拮抗剂，因此在治疗由PAF介导的各种疾病或紊乱方面具有用途。还提供包括这些化合物的药物组合物和其制备方法。

  公开号：

  US05705504A1

文献信息

• Piperidine derivatives with PAF antagonist activity
  申请人：J. Uriach & Cia, S.A.

  公开号：US05705504A1

  公开（公告）日：1998-01-06

  Compounds of general formula I and their salts and solvates are PAF antagonists and as such are useful in the treatment of various diseases or disorders mediated by PAF. Pharmaceutical compositions including these compounds and processes for their preparation are also provided.

  通式I及其盐和溶剂合物是PAF拮抗剂，因此在治疗由PAF介导的各种疾病或紊乱方面具有用途。还提供包括这些化合物的药物组合物和其制备方法。
• Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism
  作者：Merrill J. Christensen、Cari A. Olsen、David V. Hansen、Blake C. Ballif

  DOI：10.1385/bter:74:1:55

  日期：——

  Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Se-deficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 mu g Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.
• NOVEL PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0738269A1

  公开（公告）日：1996-10-23
• PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0738269B1

  公开（公告）日：2000-04-26
• US5705504A
  申请人：——

  公开号：US5705504A

  公开（公告）日：1998-01-06