2,4,6-三甲基庚烷 | 2613-61-8

• 分子结构分类: 有机化合物 - 碳氢化合物 - 饱和烃
• 中文名称: 2,4,6-三甲基庚烷
• 英文名称: 2,4,6-trimethylheptane
• 英文别名: 2,4,6-Trimethyl-heptan
• CAS: 2613-61-8
• 化学式: C₁₀H₂₂
• mdl: MFCD00048362
• 分子量: 142.285
• InChiKey: YNLBBDHDNIXQNL-UHFFFAOYSA-N

物化性质

• 熔点：
  -53.99°C
• 沸点：
  147.61°C
• 密度：
  0.7190
• LogP：
  5.334 (est)
• 保留指数：
  876.19;876.71;877.12;874;874;870;870;874

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 危险品标志：
  F,Xi
• 海关编码：
  2901100000

反应信息

• 作为产物：
  描述：

  2,4,6-三甲基-3-庚烯 在 platinum(IV) oxide 作用下， 生成 2,4,6-三甲基庚烷
  参考文献：
  名称：

  Tuot, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 197, p. 1436

  摘要：

  DOI：

文献信息

• Differences in Frequency of the Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene in Different Ethnic Groups
  作者：James Mathew、Khaja Basheeruddin、Suresha Prabhakar

  DOI：10.1177/000331970105200602

  日期：2001.6

  A polymorphism characterized by the insertion or deletion of a 287-bp Alu repeat sequence in intron 16 of the angiotensin-converting enzyme gene determines about half the serum angiotensin-converting enzyme level variability among individuals. The deletion polymorphism is associated with higher levels of angiotensin-converting enzyme and perhaps with a greater risk of cardiovascular diseases. The relative frequency of this genetic polymorphism in different ethnic groups is not known. The objective of this study was to compare the frequency of angiotensin-converting enzyme gene insertion/deletion polymorphism in different ethnic groups. Angiotensin-converting enzyme genotype was determined in middle-aged healthy hospital workers of three different ethnic origins (African Americans, whites, and Indians). There were 142 African Americans, 136 Indians, and 82 whites. The distribution of the deletion-deletion, insertion-deletion, and insertion-insertion genotypes in African Americans (29%, 60%, and 11 %, respectively), Indians (19%, 50%, and 31 %, respectively) and whites (29%, 40%, and 31 %, respectively) was significantly different (p = < 0.005). The frequency of the deletion allele among African Americans, Indians, and whites (0.59, 0.49, and 0.44, respectively) was also significantly different (p = 0.05). African Americans had the highest frequency of deletion allele and the lowest frequency of the insertion-insertion genotype among the three groups. The frequency of the deletion polymorphism of the angiotensin-converting enzyme gene is different among African Americans, whites, and Indians. This may be important in relation to the high risk of cardiovascular morbidity and mortality in African Americans and may be relevant in explaining differences in cardiovascular diseases in different populations. This finding also emphasizes the importance of studying angiotensin-converting enzyme gene polymorphism in genetically homogenous populations. Because of the small size of this study, however, these findings need further confirmation.

  一种多态性特征，由血管紧张素转换酶基因内含子16中的287-bp Alu重复序列的插入或缺失决定了个体间大约一半血清血管紧张素转换酶水平的变异性。缺失多态性与更高水平的血管紧张素转换酶以及可能更高的心血管疾病风险相关联。不同种族群体中这种遗传多态性的相对频率尚不清楚。本研究的目的是比较不同种族群体中血管紧张素转换酶基因插入/缺失多态性的频率。在三个不同种族起源（非裔美国人、白人和印第安人）的中年健康医院工作者中确定了血管紧张素转换酶基因型。有142名非裔美国人、136名印第安人和82名白人。非裔美国人（分别为29％、60％和11％）、印第安人（分别为19％、50％和31％）和白人（分别为29％、40％和31％）的缺失-缺失、插入-缺失和插入-插入基因型的分布显著不同（p = <0.005）。非裔美国人、印第安人和白人的缺失等位基因频率（分别为0.59、0.49和0.44）也显著不同（p = 0.05）。非裔美国人的缺失等位基因频率最高，插入-插入基因型频率最低。血管紧张素转换酶基因的缺失多态性在非裔美国人、白人和印第安人中不同。这可能与非裔美国人心血管发病率和死亡率高的情况相关，并可能有助于解释不同人群心血管疾病的差异。这一发现也强调了在遗传同质人群中研究血管紧张素转换酶基因多态性的重要性。然而，由于本研究规模较小，这些发现需要进一步确认。
• Kinney; Spliethoff, Journal of Organic Chemistry, 1949, vol. 14, p. 77
  作者：Kinney、Spliethoff

  DOI：——

  日期：——
• Lewina; Kleimenowa; Schuscherina, Zhurnal Obshchei Khimii, 1947, vol. 17, p. 119
  作者：Lewina、Kleimenowa、Schuscherina

  DOI：——

  日期：——
• Tuot, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 197, p. 1436
  作者：Tuot

  DOI：——

  日期：——

表征谱图