methyl 2-(aminooxy)acetate hydrochloride | 5940-07-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-(aminooxy)acetate hydrochloride
• 英文别名: O-methoxy-carbonylmethylhydroxylamine hydrochloride；methyl 2-aminooxyacetate;hydrochloride
• CAS: 5940-07-8
• 化学式: C₃H₇NO₃*ClH
• 分子量: 141.554
• InChiKey: OWANFDCZMBVHJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.53
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-(aminooxy)acetate hydrochloride 、 雌酚酮 以 甲醇 为溶剂， 反应 17.0h， 生成
  参考文献：
  名称：

  WO2007/62528

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(1,3-二氧代异吲哚啉-2-基氧基)乙酸甲酯 在 一水合肼 、 盐酸 作用下， 以 二氯甲烷 、 1,4-二氧六环 为溶剂， 生成 methyl 2-(aminooxy)acetate hydrochloride
  参考文献：
  名称：

  Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

  摘要：

  In this study, a series of bis(4-hydroxy) benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2016.01.089

文献信息

• [EN] TOPICAL FORMULATIONS<br/>[FR] FORMULATIONS TOPIQUES
  申请人：NFLECTION THERAPEUTICS INC

  公开号：WO2020106304A1

  公开（公告）日：2020-05-28

  Provided herein are gelled topical formulations for the treatment of skin diseases comprising: a) a MEK inhibitor; b) one or more organic solvents in an amount of about 70% to about 99% by weight; and c) a gelling agent; wherein the one or more organic solvents are selected from the group consisting of C2-6 alcohol, a C2-6 alkylene glycol, a di-(C2-6 alkylene) glycol, a polyethylene glycol, C1-3 alkyl-(OCH2CH2)1-5-OH, DMSO, ethyl acetate, acetone, N-methyl pyrrolidone, benzyl alcohol, glycerin, and an oil; the gelling agent is hydroxypropyl cellulose having a molecular weight ranging from about 40,000 Dato about 2,500,000 Da; and wherein the gelled topical formulation has a viscosity of from 1 to 25,000 cps; and DMSO, when present, is combined with at least one other of said organic solvents such that DMSO is present in an amount of less than 50% by weight.

  本文提供了用于治疗皮肤疾病的凝胶局部制剂，包括：a) MEK抑制剂；b) 一种或多种有机溶剂，其重量约为70%至99%；和c) 凝胶剂；其中所述一种或多种有机溶剂选自以下组：C2-6醇，C2-6烷基二醇，二-(C2-6烷基)二醇，聚乙二醇，C1-3烷基-(OCH2CH2)1-5-OH，二甲基亚砜，乙酸乙酯，丙酮，N-甲基吡咯烷酮，苯甲醇，甘油和一种油；所述凝胶剂为分子量范围约为40,000 Da至2,500,000 Da的羟丙基纤维素；其中所述凝胶局部制剂的粘度为1至25,000 cps；当存在DMSO时，将DMSO与至少一种其他所述有机溶剂结合，使DMSO的重量不超过50%。
• 喹诺酮噻唑肟类化合物及其制备方法和应用
  申请人：西南大学

  公开号：CN110330489A

  公开（公告）日：2019-10-15

  本发明涉及喹诺酮噻唑肟类化合物及其制备方法和应用，属于化学合成技术领域，喹诺酮噻唑肟类化合物如通式I所示，该类化合物对革兰阳性菌、革兰阴性菌和真菌中的一种或多种具有一定抑制活性，可以用于制备抗细菌和/或抗真菌药物，从而有机会为临床抗微生物治疗提供更多安全、高效的多样化候选药物，有助于解决日趋严重的耐药性、顽固的致病性微生物以及新出现的有害微生物等临床治疗问题。其制备原料简单，廉价易得，合成路线短，对抗感染方面的应用具有重要意义。
• Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity
  作者：Jin-Ping Chen、Narsaiah Battini、Mohammad Fawad Ansari、Cheng-He Zhou

  DOI：10.1016/j.ejmech.2021.113340

  日期：2021.5

  potency and effectively alleviate bacterial resistance. The preliminarily mechanism exploration revealed that compound 6l could destroy the cell membrane and insert into MRSA DNA to bind with DNA gyrase, then decrease the expression of gyrB and femB genes. The above results strongly suggested that methyl acetate oxime derivative 6l held a promise for combating MRSA infection.

  为了绕过喹诺酮类药物的耐药性，开发了一种新型的7-噻唑肟类喹诺酮类药物作为潜在的抗菌剂。生物学测定表明，一些构建的7-噻唑肟喹诺酮类药物具有有效的抗菌效率。乙酸甲酯肟衍生物6l的抗MRSA活性比环丙沙星高32倍，后者还具有快速的杀菌能力和对哺乳动物细胞的低毒性。7-噻唑肟喹诺酮6l和环丙沙星的组合使用能够提高抗菌效力并有效缓解细菌耐药性。初步机理探索表明，化合物6l可能破坏细胞膜并插入MRSA DNA中以与DNA促旋酶结合，从而降低gyrB和femB基因的表达。以上结果有力地表明乙酸甲酯肟衍生物6l有望抵抗MRSA感染。
• Lupane derivatives, their preparation and the pharmaceutical
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05468888A1

  公开（公告）日：1995-11-21

  The present invention relates to new lupane dervivatives of the general formula: ##STR1## to their salts, to their preparation and to the pharmaceutical compositions which contain them.

  本发明涉及一般式为：##STR1## 的新鲁班衍生物，其盐，其制备以及含有它们的药物组合物。
• Facile synthesis of 2-alkyl/aryloxy-2H-azirines and their application in the synthesis of pyrroles
  作者：Xinxin Qi、Xianxiu Xu、Cheol-Min Park

  DOI：10.1039/c2cc30490b

  日期：——

  Free carbenes generated from alpha-diazo oxime ethers by photolysis undergo facile N-O insertion to afford 2-alkyl/aryloxy-2H-azirines in good to excellent yields. This method allowed for the development of a tandem reaction for pyrrole synthesis via 1,3-dipolar cycloaddition.

  由α-重氮肟醚通过光解生成的游离碳烯容易插入NO，以良好或极好的收率得到2-烷基/芳氧基-2H-叠氮基。该方法允许通过1，3-偶极环加成反应发展用于吡咯合成的串联反应。