trans-2-decenoic acid isopropyl ester | 138878-06-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trans-2-decenoic acid isopropyl ester
• 英文别名: propan-2-yl (E)-dec-2-enoate
• CAS: 138878-06-5
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: ODECNOLARBFIAU-ZHACJKMWSA-N

物化性质

• 沸点：
  268.5±9.0 °C(Predicted)
• 密度：
  0.882±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-2-decenoic acid isopropyl ester 、 (RS)-3,5-dihydro-4H-dinaphth[2,1-c:1',2'-e]azepine 在 正丁基锂 、 12-冠醚-4 作用下， 生成 3-(3,5-Dihydro-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-decanoic acid isopropyl ester
  参考文献：
  名称：

  An asymmetric ammonia synthon for Michael additions

  摘要：

  The highly diastereoselective 1,4-addition of lithiated chiral amine 1 to alpha,beta-unsaturated esters, followed by hydrogenolysis of the benzylic-type C-N bonds of the 1,4-adducts, provides an asymmetric ammonia synthon for Michael additions. Under optimized conditions, lithiated 1 adds to alpha,beta-unsaturated tert-butyl esters in dimethoxyethane at -63-degrees-C in high yield with very high diastereoselectivity. Small, large, functionalized, and chiral beta-ester substituents are amenable, with (S)-1 consistently adding to (E)-3 from the top as drawn in Table II. Hydrogenolysis liberates the beta-amino esters with typically 95-99% ee.

  DOI：

  10.1021/jo00033a037
• 作为产物：
  描述：

  壬烯二酸 在 氯化亚砜 作用下， 反应 5.0h， 生成 trans-2-decenoic acid isopropyl ester
  参考文献：
  名称：

  Agent having neurotrophic factor-like activity

  摘要：

  公开号：

  EP2457567B1

文献信息

• Pd(II)—dppb and syngas catalyze regioselective hydroesterification of terminal alkynes under neutral conditions
  作者：Bassam El Ali、Jimoh Tijani、Abdel Moneim El-Ghanam

  DOI：10.1016/s0040-4039(01)00152-6

  日期：2001.3

  Palladium(II) regioselectively catalyzes the hydroesterification of terminal alkynes under syngas forming α,β-unsaturated esters 3 and 4 in excellent chemical yields under neutral conditions. The high selectivity for the linear ester 4 was obtained with a catalytic system that includes Pd(II), 1,4-bis(diphenylphosphino)butane (dppb) and CO/H2 in CH2Cl2 as solvent. The control of the regioselectivity

  在中性条件下，钯（II）在合成气中区域选择性地催化末端炔烃的加氢酯化反应，形成出色的化学收率的α，β-不饱和酯3和4。通过在包括CH 2 Cl 2的溶剂中包含Pd（II），1,4-双（二苯基膦基）丁烷（dppb）和CO / H 2的催化体系获得对线性酯4的高选择性。区域选择性的控制在很大程度上取决于配体的类型，溶剂和合成气混合物的使用。
• AGENT HAVING NEUROTROPHIC FACTOR-LIKE ACTIVITY
  申请人：Iinuma Munekazu

  公开号：US20100204498A1

  公开（公告）日：2010-08-12

  The present invention provides a pharmaceutical agent having high safety and a neurotrophic factor-like activity, which contains, as an active ingredient, any one compound included in fatty acids each having 8 carbon atoms (C8) or having 10 carbon atoms (C10) to 12 carbon atoms (C12) or fatty acid esters thereof, such as 3,7-dimethyloctanoic acid ethyl ester, geranic acid ethyl ester, and the like, each of which has 8 carbon atoms (C8), decanoic acid methyl ester, trans-2-decenoic acid, trans-2-decenoic acid methyl ester, trans-2-decenoic acid ethyl ester, trans-2-decenoic acid-2-decenyl ester, trans-2-decenoic acid cyclohexyl ester, trans-2-decenoic acid isopropyl ester, trans-3-decenoic acid methyl ester, trans-9-decenoic acid methyl ester, and the like, each of which has 10 carbon atoms (C10), trans-10-undecenoic acid methyl ester, trans-10-undecenoic acid ethyl ester, and the like, each of which has 11 carbon atoms (C11), and dodecanoic acid, and the like, each of which has 12 carbon atoms (C12), or salts thereof or prodrugs thereof.

  本发明提供了一种具有高安全性和神经营养因子样活性的药物制剂，其包含作为活性成分的任何一种脂肪酸，其碳原子数为8（C8）或具有10个碳原子（C10）至12个碳原子（C12）的脂肪酸酯，例如3,7-二甲基辛酸乙酯，香叶酸乙酯等，每种脂肪酸均为8个碳原子（C8），癸酸甲酯，反-2-癸烯酸，反-2-癸烯酸甲酯，反-2-癸烯酸乙酯，反-2-癸烯酸-2-癸烯酯，反-2-癸烯酸环己基酯，反-2-癸烯酸异丙酯，反-3-癸烯酸甲酯，反-9-癸烯酸甲酯等，每种脂肪酸均为10个碳原子（C10），反-10-十一烯酸甲酯，反-10-十一烯酸乙酯等，每种脂肪酸均为11个碳原子（C11），以及十二烷酸等，每种脂肪酸均为12个碳原子（C12），或其盐或前药。
• Ethylene alpha-olefin polymer substituted Mannich base lubricant dispersant additives
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0356010A1

  公开（公告）日：1990-02-28

  The present invention is directed to oil-soluble lubricating oil additives comprising Mannich Base condensates of an alkyl substituted hydroxy aromatic compound with formaldehyde and an amine, wherein the alkyl-moiety of the aromatic compounds is derived from at least one ethylene alpha-olefin copolymer of 300 to 10,000 number average molecular weight, wherein at least about 30% of the polymer's chains contain terminal ethenylidene unsaturation. The Mannich Base condensates of this invention are useful as dispersants.

  本发明涉及油溶性润滑油添加剂，包括烷基取代的羟基芳香化合物与甲醛和胺的曼尼希碱缩合物，其中芳香化合物的烷基分子来自至少一种平均分子量为 300 至 10,000 的乙烯-α-烯烃共聚物，其中至少约 30% 的聚合物链含有末端乙烯不饱和。本发明的曼尼希碱缩合物可用作分散剂。
• Ethylene alpha-olefin copolymer substituted amino phenol mannich base lubricant dispersant additives
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0357217A2

  公开（公告）日：1990-03-07

  The present invention is directed to oil-soluble lubricating oil additives comprising Mannich Base condensates of (A) and ethylene-alpha-olefin polymer substituted mono- or dicarboxylic acid material, (B) an optionally alkyl-substituted N-hydroxyaryl compound, (C) an aldehyde, and (D) an amine, wherein the polyer moiety of the mono- or dicarboxylic acid material is derived from at least one terminally unsaturated ethylene alpha-olefin copolymer of 300 to 10,000 number average molecular weight, wherein the terminal unsaturation comprises ethenylidene unsaturation. The Mannich Base condensates of this invention are useful as dispersants.

  本发明涉及油溶性润滑油添加剂，其包含以下物质的曼尼希碱缩合物：(A)和乙烯-α-烯烃聚合物取代的单羧酸或二羧酸材料；(B)任选烷基取代的 N-羟基芳基化合物；(C)醛；和(D)胺、和 (D) 一种胺，其中单羧酸或二羧酸材料的聚合体分子来自至少一种平均分子量为 300 至 10,000 的端基不饱和乙烯-α-烯烃共聚物，其中端基不饱和包括乙烯基不饱和。本发明的曼尼希碱缩合物可用作分散剂。
• Improved amide dispersant additives derived from amido-amines
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0368548A1

  公开（公告）日：1990-05-16

  The present invention is directed to a dispersant additive comprising at least one adduct of (A) a polyolefin of 300 to 10,000 number average molecular weight substituted with at least 0.5 (e.g., from about 1 to 4) monocarboxylic acid producing moieties (preferably acid or ester moieties) per polyolefin molecule, (B) an amido-amine or thioamido-amine characterized by being a reaction product of at least a polyamine and an alpha, beta-unsaturated compound of the formula: wherein X is sulfur or oxygen, Y is -OR4, -SR4, or -NR4 (R5), and R1, R2, R3, R4 and R5 are the same or different and are hydrogen or substituted or unsubstituted hydrocarbyl.

  本发明涉及一种分散剂添加剂，该添加剂包含至少一种以下物质的加合物：(A) 每聚烯烃分子中至少有 0.5 个（例如约 1 至 4 个）产生单羧酸的分子（最好是酸或酯分子）取代的平均分子量为 300 至 10,000 的聚烯烃；(B) 氨基胺或硫代氨基胺，其特征在于该氨基胺至少是一种聚胺和α、β-不饱和式化合物的反应产物： 其中 X 为硫或氧，Y 为-OR4、-SR4 或-NR4 (R5)，R1、R2、R3、R4 和 R5 相同或不同，且为氢或取代或未取代的烃基。