Boc-Gly-Pro-OSu | 64419-38-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Gly-Pro-OSu
• CAS: 64419-38-1
• 化学式: C₁₆H₂₃N₃O₇
• 分子量: 369.375
• InChiKey: AHYLTPPPKZDLSO-JTQLQIEISA-N

物化性质

• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.11
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  122.32
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  Boc-Gly-Pro-OSu 在 甲醇 、 三乙胺 、 lithium hydroxide 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design

  摘要：

  Active vaccination examining a single hapten engendered with a series of peptidic linkers has resulted in the production of antimethamphetamine antibodies. Given the limited chemical complexity of methamphetamine, the structure of the linker species embedded within the hapten could have a substantial effect on the ultimate efficacy of the resulting vaccines. Herein, we investigate linker effects by generating a series of methamphetamine haptens that harbor a linker with varying amino acid identity, peptide length, and associated carrier protein. Independent changes in each of these parameters were found to result in alterations in both the quantity and quality of the antibodies induced by vaccination. Although it was found that the consequence of the linker design was also dependent on the identity of the carrier protein, we demonstrate overall that the inclusion of a short, structurally simple, amino acid linker benefits the efficacy of a methamphetamine vaccine in limiting brain penetration of the free drug.

  DOI：

  10.1021/acschemneuro.6b00389
• 作为产物：
  描述：

  BOC-甘氨酸-N-羟基琥柏酰亚胺酯 在 碳酸氢钠 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 6.0h， 生成 Boc-Gly-Pro-OSu
  参考文献：
  名称：

  High penetration prodrug compositions of peptides and peptide-related compounds

  摘要：

  这项发明提供了一种新型高渗透性肽类化合物（HPC）或高渗透性前药（HPP）的组合物，这些化合物能够比其原始药物更高效地穿越生物屏障。HPP能够在穿越生物屏障后转化为原始药物或药物代谢物，从而可以治疗原始药物或代谢物所能治疗的疾病。此外，HPP/HPC能够到达原始药物可能无法进入或在目标区域提供足够浓度的区域，从而提供新颖的治疗方法。HPP/HPC可以通过各种给药途径给予受试者，例如，局部给药到疾病作用部位以高浓度给药，或者系统给药到生物体内并以更快的速率进入全身循环。

  公开号：

  US09248109B2

文献信息

• Copper-Catalyzed [3 + 2] Cycloaddition Reaction of <i>N</i>-Hydroxysuccinimide Ester with Isocyanoacetates for the Synthesis of 4,5-Disubstituted Oxazoles
  作者：Shuo Wang、Shi-Jie Ma、Ji-Cong Lou、Wen-Wu Sun、Bin Wu

  DOI：10.1021/acs.joc.2c03084

  日期：——

  The cycloaddition reaction of N-hydroxysuccinimide ester and isocyanatoacetate catalyzed by copper was described. A series of 4,5-disubstituted oxazole compounds, including ones derived from natural fatty acids, drugs, amino acids, and peptides, were obtained in moderate to high yields. The derivatization reaction was explored. The reaction mechanism was discussed.

  描述了铜催化的N-羟基琥珀酰亚胺酯与异氰酸根乙酸酯的环加成反应。以中高产率获得了一系列 4,5-二取代恶唑化合物，包括衍生自天然脂肪酸、药物、氨基酸和肽的化合物。探索了衍生化反应。讨论了反应机理。
• WO2008/56207
  申请人：——

  公开号：——

  公开（公告）日：——
• Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V., Journal of general chemistry of the USSR, 1984, vol. 54, # 8, p. 1696 - 1698
  作者：Il'ina, A. V.、Davidovich, Yu. A.、Rogozhin, S. V.

  DOI：——

  日期：——