Di-O-acetyl-methyltartrat | 344442-14-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Di-O-acetyl-methyltartrat
• 英文别名: 2,3-Diacetyloxy-4-methoxy-4-oxobutanoic acid
• CAS: 344442-14-4
• 化学式: C₉H₁₂O₈
• 分子量: 248.189
• InChiKey: GVCSACPSWHMFIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Di-O-acetyl-methyltartrat 在 氯化亚砜 作用下， 反应 2.0h， 以97%的产率得到Methyl 2,3-diacetyloxy-4-chloro-4-oxobutanoate
  参考文献：
  名称：

  Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

  摘要：

  In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

  DOI：

  10.2174/157017810790796336
• 作为产物：
  描述：

  甲醇 、 O²,O³-diacetyl-tartaric acid anhydride 反应 0.25h， 以100%的产率得到Di-O-acetyl-methyltartrat
  参考文献：
  名称：

  Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

  摘要：

  In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

  DOI：

  10.2174/157017810790796336

文献信息

• Determination of the absolute configuration of picrasidine Y, a naturally occurring β-carboline alkaloid
  作者：Kazuo Koike、Hiroshi Yoshino、Hong-yu Li、Tatsunori Sasaki、Wei Li

  DOI：10.1016/j.tetlet.2015.07.079

  日期：2015.9

  to canthin-5,6-dione compounds. The absolute configuration of natural picrasidine Y was elucidated based on comparisons of chemically synthesized isoforms with the naturally occurring compound in 1H and 13C NMR spectra, specific optical rotation, HPLC analysis with chiral columns, computational molecular simulation, and analysis with the CD exciton chirality method.

  尚未确定从拟南芥（Simaroubaceae）分离出的β-咔啉生物碱吡喃ras啶Y的绝对构型。为了确定吡喃吡啶Y的绝对构型，我们使用酒石酸作为起始原料通过7步化学反应合成了吡喃吡啶Y的立体异构体。此外，我们将这种合成方法的应用范围扩展到了canthin-5,6-dione化合物。基于化学合成的同工型与天然存在的化合物在1 H和13 C NMR光谱中的比较，比旋光度，手性色谱柱HPLC分析，计算分子模拟和CD激子分析，阐明了天然苦味苷Y的绝对构型手性法。
• Process for the preparation of meso-zeaxanthin
  申请人：——

  公开号：US20030092775A1

  公开（公告）日：2003-05-15

  A process for the preparation of optically pure acetylenediols of the formulae R-I and S-I 1 and their further reaction to give meso-zeaxanthin are described.

  本文描述了制备式R-I和S-I1的光学纯乙炔二醇的过程，以及它们进一步反应形成中间型玉米黄素的过程。
• Methods and compositions for preventing opioid abuse
  申请人：Albany Molecular Research, Inc.

  公开号：US11020386B2

  公开（公告）日：2021-06-01

  Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.

  提供了抗滥用阿片类化合物、给药系统、药物组合物，其中包含与化学分子共价结合的阿片类药物。 此外，还提供了向受试者输送活性成分的方法和防止滥用阿片类药物的方法。
• Stabilization of cooked and fully hydrated potato compositions
  申请人：——

  公开号：US20040228949A1

  公开（公告）日：2004-11-18

  The present invention provides starchy food products, especially cooked and fully hydrated potato compositions, including fully hydrated mashed potato compositions and fully hydrated cut potato compositions, which are stabilized against the development of toxins from pathogenic bacterial contaminants. The stabilized compositions are attained by the incorporation of nisin-containing dairy composition derived from a nisin-producing culture. The invention also relates to methods of stabilizing starchy food products, especially cooked and fully hydrated potato compositions, including fully hydrated mashed potato compositions and fully hydrated cut potato compositions, against the development of toxins, wherein the method comprises incorporating nisin-containing dairy composition derived from a nisin-producing culture to the starchy food product. Since these compositions are cooked and fully hydrated prior to packaging, the ultimate consumer only needs to briefly heat the starchy food product in, for example, a conventional or microwave oven prior to consumption.

  本发明提供了淀粉类食品，特别是煮熟和完全水合的马铃薯组合物，包括完全水合的马铃薯泥组合物和完全水合的切块马铃薯组合物，这些组合物具有稳定性，可防止致病细菌污染物产生毒素。这种稳定化的组合物是通过加入从产nisin培养物中提取的含nisin的乳制品组合物来实现的。本发明还涉及稳定淀粉类食品的方法，特别是熟的和完全水合的马铃薯组合物，包括完全水合的马铃薯泥组合物和完全水合的马铃薯块组合物，以防止毒素的产生，其中该方法包括在淀粉类食品中加入从产尼生素的培养物中提取的含尼生素的乳制品组合物。由于这些组合物在包装前已煮熟并完全水合，最终消费者在食用前只需在例如传统或微波炉中短暂加热淀粉类食品即可。
• MEGANEM, F., J. IRAGI CHEM. SOC., 1980, 5, N ISSUE, 202-209
  作者：MEGANEM, F.

  DOI：——

  日期：——