4-(1-茚满基)苯酚 | 5402-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 4-(1-茚满基)苯酚
• 英文名称: 4-(2,3-dihydro-1H-inden-1-yl)phenol
• 英文别名: 4-indanylphenol；(+/-)-4-Hydroxy-1-(indanyl-(1))-benzol；4-Indan-1-yl-phenol；1-(4-Oxy-phenyl)-hydrinden；4-(Hydrindyl-(1))-phenol；p-(1-indanyl)-phenol；4-(1-Indanyl)Phenol
• CAS: 5402-37-9
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: GISZMQWQAFRGHL-UHFFFAOYSA-N

物化性质

• 沸点：
  359.0±21.0 °C(Predicted)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为反应物：
  描述：

  4-(1-茚满基)苯酚 以103 mg (75%)的产率得到Methyl 2-[2-[4-(1-indanyl)phenoxymethyl]phenyl]-3-methoxypropenoate
  参考文献：
  名称：

  Selected novel aryl acrylics

  摘要：

  式I的新化合物及制备和使用这些化合物的方法，这些化合物在农业领域中特别作为杀菌剂有用：其中C.sub.1和C.sub.2是芳香环的一部分的碳原子；W是烷氧基亚胺基、烷氧基亚甲基或烷基硫亚甲基；R.sub.1独立地选择自卤素、氰基、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基的群组，其中烷基或烷氧基可以选择由卤素取代，p为0、1或2；Z是--CH.sub.2--、--CH(OH)--、--CO--、--O--、--S--、NR.sub.2，其中R.sub.2是氢或低脂肪基，--CH.sub.2 CH.sub.2--、--CH.dbd.CH--、--CH.sub.2 O--、--CH.sub.2 S--、--CH.sub.2 S(O)--、--OCH.sub.2--、--SCH.sub.2--、--S(O)CH.sub.2--、--CH.sub.2 ON.dbd.C(R.sub.3)--或--CH.dbd.NB，其中B是--O--CO--、--N.dbd.CR.sub.3或--CR.sub.3 R.sub.4--，其中R.sub.3和R.sub.4独立地是氢或C.sub.1-C.sub.4烷基，可以选择由卤素取代；A是具有1-2芳香环的芳香基，从Z到I.sub.1线性连接，其中芳香环可以选择与彼此和I.sub.1以氧、氮或硫的线性方式连接；q为0或1。I.sub.1是：或其农学上可接受的盐。

  公开号：

  US05739140A1
• 作为产物：
  描述：

  1-(4-hydroxyphenyl)-1-methoxy-3-phenylpropane 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以75%的产率得到4-(1-茚满基)苯酚
  参考文献：
  名称：

  A systematic study of benzyl cation initiated cyclization reactions

  摘要：

  A systematic investigation of benzyl cation initiated cyclization reactions to form six-membered carbocycles is presented. The generation of benzyl cations from benzylic bromides, ethers, and alcohols followed by intramolecular capture provided good yields of cyclized products by use of several different cyclization terminators (e.g., phenyl, alkene, beta-keto ester). A study on the effect of changing the electronic nature of substituents para to the benzyl cation showed that even electron-withdrawing substituents such as quaternary ammonium afford high yields of cyclization products. The formation of five- and seven-membered carbocycles was briefly investigated and found to be less general than the formation of the corresponding six-membered carbocycles.

  DOI：

  10.1021/jo00008a049

文献信息

• Gold-Catalyzed Friedel-Crafts-Like Reaction of Benzylic Alcohols to Afford 1,1-Diarylalkanes
  作者：James V. Oakley、Tyler J. Stanley、Kate A. Jesse、Amanda K. Melanese、Araceli A. Alvarez、Aloha L. Prince、Stephanie E. Cain、Anna G. Wenzel、Robert G. Iafe

  DOI：10.1002/ejoc.201901082

  日期：2019.11.14

  A gold‐catalyzed, Friedel–Crafts‐like benzylation of unactivated benzylic alcohols to form 1,1‐diarylalkanes has been developed. The operationally convenient method uses only 1.3 equivalents of electron‐rich arene, employs readily available starting materials, is highly reproducible, and is tolerant to moisture. Moderate‐to‐high product yields (34–99 %) with excellent regioselectivity were obtained

  已经开发了一种金催化的未活化的苄醇的弗里德尔-克拉夫茨样苄基化反应，形成1,1-二芳基烷烃。操作简便的方法仅使用1.3当量的富电子芳烃，采用容易获得的起始原料，具有高度重现性，并且耐潮。获得了中等到高的产品收率（34–99％），具有出色的区域选择性。
• SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF
  申请人：CAO Bin

  公开号：US20100075994A1

  公开（公告）日：2010-03-25

  The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

  本发明涉及一系列取代二氢和四氢噁唑嘧啶酮，具体地说，涉及一系列式(I)的2-取代-2,3-二氢-噁唑并[3,2-a]嘧啶-7-酮和2-取代-2,3,5,6-四氢-噁唑并[3,2-a]嘧啶-7-酮： 其中p、n、X、Y、R1、R2、R3、R4、R5、R6、R7和R8如本文所定义。本发明还涉及制备这些化合物的方法，包括新颖的中间体。本发明的化合物是代谢型谷氨酸受体（mGluR）的调节剂，特别是mGluR2受体。因此，本发明的化合物在药物制剂中具有用途，特别是在治疗和/或预防各种中枢神经系统疾病（CNS）方面，包括但不限于急性和慢性神经退行性疾病、精神病、癫痫、焦虑、抑郁、偏头痛、疼痛、睡眠障碍和呕吐。
• Pharmaceutical compositions for the treatment of CNS and other discorders
  申请人：Pfizer Inc.

  公开号：US20020177591A1

  公开（公告）日：2002-11-28

  The present invention relates to a method of treating disorders of the central nervous system (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant &agr;7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant &agr;7 nicotinic receptor agonist.

  本发明涉及一种治疗哺乳动物（包括人类）中枢神经系统（CNS）和其他疾病的方法，通过向哺乳动物施用一种穿透中枢神经系统的α7尼古丁受体激动剂。还涉及含有药用载体和穿透中枢神经系统的α7尼古丁受体激动剂的药物组合物。
• [EN] SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH<br/>[FR] MODULATEURS SÉLECTIFS DES RÉCEPTEURS DE LA SPHINGOSINE-1-PHOSPHATE ET TRAITEMENT COMBINÉ LES UTILISANT
  申请人：RECEPTOS INC

  公开号：WO2015066515A1

  公开（公告）日：2015-05-07

  Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided, including compounds which modulate subtype 1 of the S1P receptor, and methods of their therapeutic and/or prophylactic use in combination with at least one other medicament adapted for treatement of a malcondition for which activation of S1P1 is medically indicated, such as multiple sclerosis.

  提供了选择性调节神经酰胺1磷酸受体的化合物，包括调节S1P受体亚型1的化合物，以及它们在与至少一种其他适用于治疗激活S1P1的药物联合使用的治疗和/或预防用途的方法，例如多发性硬化症。
• Gold-Catalyzed, SN1-Type Reaction of Alcohols to Afford Ethers and Cbz-Protected Amines
  作者：Anna Wenzel、Andrew Vinson、Victoria Davis、Arunamarie Arunasalam、Kate Jesse、Rachael Hamilton、Morgan Shattuck、Allison Hu、Robert Iafe

  DOI：10.1055/s-0034-1380128

  日期：——

  intermolecular, SN1-type reaction to directly form unsymmetrical ethers and N-benzyloxy carbamate- (Cbz) protected amines is reported. Results have shown this reaction to be highly reproducible and tolerant of moisture, and moderate to high product yields (53–99%) were obtained. Significantly, the intermolecular catalytic amination of alcohols to directly afford Cbz-protected amines is heretofore unprecedented

  据报道，使用金催化的微波协议通过分子间 SN1 型反应活化醇，直接形成不对称醚和 N-苄氧基氨基甲酸酯 (Cbz) 保护的胺。结果表明该反应具有高度重现性和耐湿性，并且获得了中等至高的产品产率（53-99%）。值得注意的是，醇的分子间催化胺化直接提供 Cbz 保护的胺是迄今为止前所未有的使用金催化。

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