Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: a route to enantiopure β-amino-α-hydroxy acids
摘要:
Chiral alpha -dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-beta -dibenzylamino-alpha -hydroxy-cyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure beta -amino-alpha -hydroxy acids. (C) 2001 Elsevier Science Ltd. All rights reserved.
Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: a route to enantiopure β-amino-α-hydroxy acids
摘要:
Chiral alpha -dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-beta -dibenzylamino-alpha -hydroxy-cyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure beta -amino-alpha -hydroxy acids. (C) 2001 Elsevier Science Ltd. All rights reserved.
Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: a route to enantiopure β-amino-α-hydroxy acids
作者:José M. Andrés、Marı́a A. Martı́nez、Rafael Pedrosa、Alfonso Pérez-Encabo
DOI:10.1016/s0957-4166(01)00044-1
日期:2001.2
Chiral alpha -dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-beta -dibenzylamino-alpha -hydroxy-cyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure beta -amino-alpha -hydroxy acids. (C) 2001 Elsevier Science Ltd. All rights reserved.