2,4-Dimethoxybenzoylcoronene | 292624-74-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 2,4-Dimethoxybenzoylcoronene
• 英文别名: coronen-1-yl-(2,4-dimethoxyphenyl)methanone
• CAS: 292624-74-9
• 化学式: C₃₃H₂₀O₃
• 分子量: 464.52
• InChiKey: IZZGZIXGNPHDBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-Dimethoxybenzoylcoronene 在 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 75.0h， 生成 (2,5-Dioxopyrrolidin-1-yl) 3-[coronen-1-yl-(2,4-dimethoxyphenyl)-hydroxymethyl]benzoate
  参考文献：
  名称：

  Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels

  摘要：

  The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00737-1
• 作为产物：
  描述：

  2,4-二甲氧基苯甲酰氯 、 晕苯 在 三氯化铝 作用下， 以 氯苯 为溶剂， 以48%的产率得到2,4-Dimethoxybenzoylcoronene
  参考文献：
  名称：

  Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels

  摘要：

  The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00737-1

文献信息

• Trityl-type compounds and their use
  申请人：——

  公开号：US20030175742A1

  公开（公告）日：2003-09-18

  Trityl-type compounds comprise, bonded to the same atom, three aryl groups, of which at least one is a fluorophore and at least one has a substituent including a functional group, and wherein the compound can exist in a non-ionised state or in an ionised state conjugated with the aryl groups.

  Trityl型化合物由三个芳基基团构成，这些基团与同一原子键合，其中至少一个是荧光团，至少一个具有包括功能基团的取代基，该化合物可以存在于非离子态或与芳基团共轭的离子态。
• TRITYL-TYPE COMPOUNDS AND THEIR USE
  申请人：ISIS INNOVATION LIMITED

  公开号：EP1268706A1

  公开（公告）日：2003-01-02
• US6809220B2
  申请人：——

  公开号：US6809220B2

  公开（公告）日：2004-10-26
• US6946575B2
  申请人：——

  公开号：US6946575B2

  公开（公告）日：2005-09-20
• [EN] TRITYL-TYPE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSES DE TYPE TRITYLE ET LEUR UTILISATION
  申请人：ISIS INNOVATION

  公开号：WO2001072926A1

  公开（公告）日：2001-10-04

  Trityl-type compounds comprise, bonded to the same atom, three aryl groups, of which at least one is a fluorophore and at least one has a substituent including a functional group, and wherein the compound can exist in a non-ionised state or in an ionised state conjugated with the aryl groups.