cis-Ru(Bpy)2Cl2·2H2O | 15746-57-3

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: cis-Ru(Bpy)2Cl2·2H2O
• 英文别名: cis-[Ru(2,2'-bipyridine)2Cl2]*2H2O；bis(2,2'-bipyridine)ruthenium(II)Cl2*2H2O；dichlororuthenium;2-pyridin-2-ylpyridine;hydrate
• CAS: 15746-57-3
• 化学式: C₁₀H₈Cl₂N₂Ru*2H₂O
• 分子量: 364.193
• InChiKey: ARIFHMAZQBLEDY-UHFFFAOYSA-L

物化性质

• 熔点：
  198-200℃

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 安全说明：
  S24/25

反应信息

• 作为反应物：
  描述：

  cis-Ru(Bpy)2Cl2·2H2O 在 Na/C₂H₅OH 作用下， 以 乙醇 、 乙腈 为溶剂， 生成 Ru(2,2'-bipyridine)2S5
  参考文献：
  名称：

  Greaney; Coyle; Harmer, Inorganic Chemistry, 1989, vol. 28, # 5, p. 912 - 920

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2'-联吡啶 、 ruthenium(III) chloride trihydrate 在 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以58%的产率得到cis-Ru(Bpy)2Cl2·2H2O
  参考文献：
  名称：

  Ln2M complexes (M = Ru, Re) derived from a bismacrocyclic ligand containing a 4,4′-dimethyl-2,2′-bipyridyl bridging unit

  摘要：

  以一个具有两个DO3A配位位点的配体为基础，通过一个4,4'-二甲基-2,2'-联吡啶间隔物制备并表征了同核双金属镧系金属络合物。1的联吡啶配位位点被用来引入Ru(Bpy)2和Re(CO)3Cl基团，从而形成具有一般式[Ln2·1·Ru(Bpy)2]2+（Ln = Nd, Eu, Tb, Yb和Lu）和[Ln2·1·Re(CO)3Cl]（Ln = Nd, Yb和Lu）的异金属d–f2络合物。通过吸收光谱、稳态和时间分辨光谱技术研究了络合物的发光特性，涵盖了可见光和近红外（NIR）区域。结果表明，无论是在水溶液中，Ru和Re色团都能有效敏化Yb和Nd的NIR发射。我们还考虑了Ln2·1络合物中Ln阳离子的未饱和配位球，这些络合物与双齿阴离子形成三元络合物，而没有显示出对多阴离子物种的特定协同效应。

  DOI：

  10.1039/c2dt32660d

文献信息

• Synthesis and Characterization of Photorefractive Polymers Containing Transition Metal Complexes as Photosensitizer
  作者：Zhonghua Peng、Ali R. Gharavi、Luping Yu

  DOI：10.1021/ja970048l

  日期：1997.5.1

  This paper reports detailed synthesis and characterization of a hybridized polymer system which combines the ionic transition metal complexes and a conjugated polymer backbone bearing NLO chromophores to manifest a large photorefractive (PR) effect. In this system, the conjugated polymer backbone was chosen to play the dual role of a transporting channel for the charge carriers and a macroligand to

  本文报告了杂化聚合物系统的详细合成和表征，该系统结合了离子过渡金属配合物和带有 NLO 发色团的共轭聚合物主链，以表现出大的光折变 (PR) 效应。在该系统中，共轭聚合物主链被选择为电荷载流子的传输通道和与过渡金属络合物螯合的大配体的双重作用。Ru(II)-三(双吡啶基)配合物利用其金属到配体的电荷转移特性被选为光电荷发生器。Heck 偶联反应用于合成这些多功能聚合物。在极化样品上观察到零电场下的大净光学增益 (>200 cm-1)。合成方法是通用的，并扩展到含有 Os 配合物的 PR 聚合物的合成。所得聚合物在近红外区域 (780 nm) 的波长下显示出光折变性。这种方法还提供了微调......
• Cytotoxicity, cellular uptake, cell cycle arrest, apoptosis, reactive oxygen species and DNA-binding studies of ruthenium(II) complexes
  作者：Yang-Yin Xie、Gan-Jian Lin、Guang-Bin Jiang、Zhen-Hua Liang、Hong-Liang Huang、Yun-Jun Liu

  DOI：10.1007/s11243-013-9724-6

  日期：2013.8

  performed. The complexes were found to show moderate DNA-binding affinities and high cytotoxicities toward A549, BEL-7402, MG-63 and SKBR-3 cell lines. These complexes can effectively induce apoptosis of BEL-7402. In cell cycle assays, the complexes induced S-phase arrest on BEL-7402 cells and G0/G1-phase arrest on SKBR-3 cells. The DNA-binding experiments showed that the three complexes interact with

  合成了三种钌(II)多吡啶配合物[Ru(dmb)2(dadppz)]2+1、[Ru(bpy)2(dadppz)]2+2和[Ru(phen)2(dadppz)]2+3并通过元素分析、ES-MS、1H NMR和13C NMR表征。通过吸收滴定、荧光光谱和粘度测量研究了它们的 DNA 结合行为。进行了体外细胞毒性、细胞凋亡、细胞周期停滞、细胞摄取和活性氧物质测定。发现复合物对 A549、BEL-7402、MG-63 和 SKBR-3 细胞系显示出中等的 DNA 结合亲和力和高细胞毒性。这些复合物可有效诱导 BEL-7402 凋亡。在细胞周期测定中，复合物诱导 BEL-7402 细胞的 S 期停滞和 SKBR-3 细胞的 G0/G1 期停滞。
• Graphene quantum dots mediated electron transfer in DNA base pairs
  作者：Chang Liu、Linqing Guo、Biao Zhang、Liping Lu

  DOI：10.1039/c9ra05481b

  日期：——

  measurements. Various DNA types were immobilized on Au electrodes via Au–S bonds. Electrochemiluminescence and electrochemical measurements indicate that [Ru(bpy)3–GQD]2+ could enhance DNA-mediated charge transfer when intercalated into an abasic site of double stranded DNA. And comparing with [Ru(bpy)3]2+, it can be concluded that GQDs intercalate into the DNA duplex by acting as a base analog, thus enhancing

  石墨烯量子点 (GQD) 连接到 [Ru(bpy) 3 ] 2+以感应 DNA 介导的电荷转移。通过吸收光谱、凝胶电泳、圆二色性和熔解温度测量研究了脱碱基位点双链 DNA (Abasic-DNA) 和 [Ru(bpy) 3 –GQD] 2+之间的相互作用。结果表明[Ru(bpy) 3 –GQD] 2+可以嵌入双链DNA中。使用[Ru(bpy) 3 –GQD] 2+作为信号分子，通过电化学和电化学发光测量确定DNA插入的[Ru(bpy) 3 –GQD] 2+的电荷转移性能。各种 DNA 类型通过Au-S 键固定在 Au 电极上。电化学发光和电化学测量表明，[Ru(bpy) 3 –GQD] 2+当插入双链 DNA 的脱碱基位点时可以增强 DNA 介导的电荷转移。与[Ru(bpy) 3 ] 2+相比，可以得出结论，GQDs通过充当碱基类似物插入DNA双链体中，从而增强DNA电荷转移。这些发现表明
• The effects of linear assembly of two carbazole groups on acid–base and DNA-binding properties of a ruthenium(II) complex
  作者：Xi Chen、Long-Xin Xue、Chun-Chuan Ju、Ke-Zhi Wang

  DOI：10.1016/j.saa.2013.04.017

  日期：2013.7

  A novel Ru(II) complex of [Ru(bpy)(2)(Hbcpip)](ClO4)(2) where bpy = 2,2-bipyridine, Hbcpip = 2-(4-(9H-3,9'-bicarbazol-9-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline} is synthesized and characterized. Calfthymus DNA-binding properties of the complex were studied by UV-vis absorption and luminescence titrations, steady-state emission quenching by [Fe(CN)(6)](4-), DNA competitive binding with ethidium bromide, thermal denaturation and DNA viscosity measurements. The results indicate that the complex partially intercalated into the DNA with a binding constant of (5.5 +/- 1.4) x 10(5) M-1 in buffered 50 mM NaCl. The acid-base properties of the complex were also studied by UV-visible and luminescence spectrophotometric pH titrations, and ground- and excited-state acidity ionization constant values were derived. (C) 2013 Elsevier B.V. All rights reserved.
• Synthesis and characterisation of ruthenium polypyridyl complexes containing a pendent hydroquinone grouping
  作者：Frances M Weldon、Johannes G Vos

  DOI：10.1016/s0020-1693(00)00180-8

  日期：2000.9

  The synthesis of the ligand 1,4-dihydroxy-2,5-bis(3-(pyridin-2-yl)-1,2,4-triazol-1-yl)benzene (L1) and its mono and dinuclear rutheniumbis(2,2'-bipyridyl) complexes are reported. The compounds obtained are characterised by NMR, UV-Vis and emission spectroscopy and have also been studied by electrochemical and spectroelectrochemical techniques. The data obtained suggest that L1 is bound to the metal centre via the pyridine ring and the N4 atom of the triazole moiety. The compounds emit at room temperature and electrochemical studies show that the central hydroquinone unit is oxidised before the ruthenium centres. (C) 2000 Elsevier Science S.A.. All rights reserved.