glycyl-L-alanyl-L-alanine | 6491-25-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glycyl-L-alanyl-L-alanine
• 英文别名: glycylalanylalanine；Gly-L-Ala-L-Ala；Gly-Ala-Ala-OH；glycyl=>L-alanyl=>L-alanine；H-Gly-Ala-Ala-OH；Glycyl=>L-alanyl=>L-alanin；(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]propanoic acid
• CAS: 6491-25-4
• 化学式: C₈H₁₅N₃O₄
• mdl: MFCD00057631
• 分子量: 217.225
• InChiKey: PYTZFYUXZZHOAD-WHFBIAKZSA-N

物化性质

• 沸点：
  581.8±45.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  glycyl-L-alanyl-L-alanine 、 亚硝基叔丁烷 在 过氧化苯甲酰 作用下， 以 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  过氧化二苯甲酰引起的氨基酸和肽的光脱羧。诱捕研究

  摘要：

  DOI：

  10.1021/j150616a021
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 钯 、 溶剂黄146 作用下， 生成 glycyl-L-alanyl-L-alanine
  参考文献：
  名称：

  Optical Rotation of Peptides. II. Glycine and Alanine Tripeptides¹

  摘要：

  DOI：

  10.1021/ja01151a513

文献信息

• Metal Complexes of Peptides. III. The Preparation and Properties of Diammine(oligopeptidato)cobalt(III) Complexes
  作者：Hiroshi Kawaguchi、Mari Ishii、Tomoharu Ama、Takaji Yasui

  DOI：10.1246/bcsj.55.3750

  日期：1982.12

  Complexes of the [Co(tripeptidato)(NH3)2] and NH4[Co(tetrapeptidato)(NH3)2] types (tripeptidato and tetrapeptidato denote the tri- and tetraanions of the coordinating peptides respectively) have been prepared and characterized by means of their electronic, 1H NMR, and circular dichroism (CD) spectral data. In the NH4[Co(tetrapeptidato) (NH3)2] complex, the pep tide coordinates to cobalt(III) as a quadridentate

  [Co(tripeptidato)(NH3)2] 和 NH4[Co(tetrapeptidato)(NH3)2] 类型的复合物（三肽和四肽分别表示配位肽的三阴离子和四阴离子）已被制备和表征它们的电子、1H NMR 和圆二色性 (CD) 光谱数据。在 NH4[Co(tetrapeptidato) (NH3)2] 复合物中，肽通过氨基和三个酰胺基团的氮与钴 (III) 作为四齿配体配位。已发现邻位 CD 光谱的可加性适用于一系列含有 L-丙氨酸和/或甘氨酸残基的三肽的复合物。这些三肽和四肽复合物在水中很容易发生水化反应，释放出氨分子。
• NUTRITIVE EMULSION
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0312612A1

  公开（公告）日：1989-04-26

  The present invention provides a nutritive emulsion characterized in that the emulsion comprises essential components of about 4 to about 15% by weight of an amino acid preparation, about 3 to about 12% by weight of a lipid, about 71.5 to about 93% by weight of water, and about 0.3 to about 3.0% by weight of an emulsifier having an HLB of at least 13 and selected from the group consisting of sucrose fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester and polyoxyethylene sorbitan fatty acid ester, or an emulsifier mixture of said emulsifier and soybean lecithin and in that the emulsion has a pH of about 6.5 to about 8.5.

  本发明提供了一种营养乳剂，其特征在于该乳剂包括按重量计约4至约15%的氨基酸制剂、按重量计约3至约12%的脂质、按重量计约71.5至约93%的水、按重量计约0.3至约3.0%（重量）的乳化剂，该乳化剂的 HLB 至少为 13，并且选自由蔗糖脂肪酸酯、甘油脂肪酸酯、聚氧乙烯甘油脂肪酸酯和聚氧乙烯山梨糖醇酐脂肪酸酯组成的组，或上述乳化剂和大豆卵磷脂的乳化剂混合物，乳液的 pH 值为约 6.5 至约 8.5。
• Schwederski, Brigitte E.; Basile-D'Alessandro, Franco; Dickson, Peter N., Inorganic Chemistry, 1989, vol. 28, # 18, p. 3477 - 3480
  作者：Schwederski, Brigitte E.、Basile-D'Alessandro, Franco、Dickson, Peter N.、Lee, Hsiupu D.、Raycheba, John M. T.、Margerum, Dale W.

  DOI：——

  日期：——
• Au(III)-complexes of the alanyl-containing peptides glycylalanine and glycylalanylalanine – Synthesis, spectroscopic and structural characterization
  作者：Ts. Kolev、B.B. Koleva、S.Y. Zareva、M. Spiteller

  DOI：10.1016/j.ica.2006.05.034

  日期：2006.10

  As part of an investigation on the coordination ability of peptides, the dipeptide glycylalanine (H-Gly-Ala-OH), tripeptide glycylalanylalanine (H-Gly-Ala-Ala-OH) and their Au(III)-complexes have been characterized structurally. The quantum chemical calculations and linear-dichroic infrared (IR-LD) spectroscopy predict structures of the compound studied, which are compared with a single crystal X-ray diffraction of H-Gly-Ala-OH. The coordination processes with Au(III) are supported by data for H-1 NMR, ESI-MS, HPLC-MS-MS. TGV and DSC methods. The [Au(Gly-Ala)H-1Cl] and [Au(Gly-Ala-Ala)H-2]center dot 2H(2)O complexes are formed via -NH2, N(-)amide/s and CO2- groups of the peptides. One Cl- ion is attached to the metal center as terminal ligand in the first complex. In both cases a near to square-planar geometry of the chromophors AuN2OCl and AuN3O is yielded. (c) 2006 Elsevier B.V. All rights reserved.
• EXTERNAL GRADIENT CHROMATOFOCUSING
  申请人：Cryobiophysica, Inc.

  公开号：EP1628729A2

  公开（公告）日：2006-03-01

表征谱图